日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues

2,4-二氨基噻唑系列药物的开发用于治疗非洲人类锥虫病,凸显了类似物静态杀灭筛选的重要性

Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, Iain T Collie, Irene Hallyburton, Robert Kime, Frederick R C Simeons, Laste Stojanovski

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening

一种支架,三种结合模式:通过虚拟筛选发现的片段匹配的新型选择性蝶啶还原酶 1 抑制剂

Chidochangu P Mpamhanga, Daniel Spinks, Lindsay B Tulloch, Emma J Shanks, David A Robinson, Iain T Collie, Alan H Fairlamb, Paul G Wyatt, Julie A Frearson, William N Hunter, Ian H Gilbert, Ruth Brenk