日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of Aldehyde-Alkyne-Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers

利用醛-炔-胺偶联反应生成与药物化学相关的连接基

McGown, Andrew; Vetma, Vesna; Crepin, Damien; Lin, Yan; Adcock, Claire; Craigon, Conner; Nafie, Jordan; von Emloh, Daniel; Sutton, Léa; Bailey, Kiera; Edmunds, Lewis; Sharma, Manvendra; Wilden, Jonathan D; Coles, Simon J; Tizzard, Graham J; Farnaby, William; Ciulli, Alessio; Kostakis, George E; Spencer, John

Characterization of the Active Enantiomer and Mapping of the Stereospecific Intermolecular Pattern of a Reference P2X7 Allosteric Antagonist

活性对映体的表征及参考P2X7变构拮抗剂立体特异性分子间模式的绘制

McGown, Andrew; Renault, Nicolas; Barczyk, Amélie; Nafie, Jordan; Barluzzi, Luciano; Guest, Daniel; Tizzard, Graham J; Coles, Simon J; Leach, David; von Emloh, Daniel; Sutton, Léa; Bailey, Kiera; Edmunds, Lewis; Greenland, Barnaby W; Millet, Régis; Spencer, John; Dezitter, Xavier

The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境增强癌症检查点免疫疗法的疗效。

Elizabeth L Hardaker # ,Emilio Sanseviero # ,Ankur Karmokar # ,Devon Taylor # ,Marta Milo ,Chrysis Michaloglou ,Adina Hughes ,Mimi Mai ,Matthew King ,Anisha Solanki ,Lukasz Magiera ,Ricardo Miragaia ,Gozde Kar ,Nathan Standifer ,Michael Surace ,Shaan Gill ,Alison Peter ,Sara Talbot ,Sehmus Tohumeken ,Henderson Fryer ,Ali Mostafa ,Kathy Mulgrew ,Carolyn Lam ,Scott Hoffmann ,Daniel Sutton ,Larissa Carnevalli ,Fernando J Calero-Nieto ,Gemma N Jones ,Andrew J Pierce ,Zena Wilson ,David Campbell ,Lynet Nyoni ,Carla P Martins ,Tamara Baker ,Gilberto Serrano de Almeida ,Zainab Ramlaoui ,Abdel Bidar ,Benjamin Phillips ,Joseph Boland ,Sonia Iyer ,J Carl Barrett ,Arsene-Bienvenu Loembé ,Serge Y Fuchs ,Umamaheswar Duvvuri ,Pei-Jen Lou ,Melonie A Nance ,Carlos Alberto Gomez Roca ,Elaine Cadogan ,Susan E Critichlow ,Steven Fawell ,Mark Cobbold ,Emma Dean ,Viia Valge-Archer ,Alan Lau ,Dmitry I Gabrilovich ,Simon T Barry

The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance

新一代口服选择性雌激素受体降解剂卡米泽司群 (AZD9833) 可抑制 ER+ 乳腺癌的生长并克服内分泌和 CDK4/6 抑制剂耐药性。

Mandy Lawson # ,Natalie Cureton # ,Susana Ros # ,Azadeh Cheraghchi-Bashi ,Jelena Urosevic ,Sophie D'Arcy ,Oona Delpuech ,Michelle DuPont ,David I Fisher ,Eric T Gangl ,Hilary Lewis ,Dawn Trueman ,Neha Wali ,Stuart C Williamson ,Jennifer Moss ,Elodie Montaudon ,Heloise Derrien ,Elisabetta Marangoni ,Ricardo J Miragaia ,Sladjana Gagrica ,Pablo Morentin-Gutierrez ,Thomas A Moss ,Gareth Maglennon ,Daniel Sutton ,Radoslaw Polanski ,Alan Rosen ,Jonathan Cairns ,Pei Zhang ,Mònica Sánchez-Guixé ,Violeta Serra ,Susan E Critchlow ,James S Scott ,Justin P O Lindemann ,Simon T Barry ,Teresa Klinowska ,Christopher J Morrow ,Larissa S Carnevalli

Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models

AKT 抑制剂 capivasertib 与 SERD 氟维司群联合使用对 palbociclib 耐药的 ER+ 乳腺癌临床前模型有效

Lorna Hopcroft, Eleanor M Wigmore, Stuart C Williamson, Susana Ros, Cath Eberlein, Jennifer I Moss, Jelena Urosevic, Larissa S Carnevalli, Sara Talbot, Lauren Bradshaw, Catherine Blaker, Sreeharsha Gunda, Venetia Owenson, Scott Hoffmann, Daniel Sutton, Stewart Jones, Richard J A Goodwin, Brandon S W

Presentation, Treatment, and Natural Course of Severe Symptoms of Urinary Tract Infections Measured by a Smartphone App: Observational and Feasibility Study

利用智能手机应用程序评估尿路感染严重症状的表现、治疗和自然病程:一项观察性和可行性研究

Vellinga, Akke; Farrell, Karen; Fallon, Roisin; Hare, Daniel; Sutton-Fitzpatrick, Una; Cormican, Martin

A general method for elicitation, imputation, and sensitivity analysis for incomplete repeated binary data

一种用于不完整重复二元数据的提取、插补和敏感性分析的通用方法

Tompsett, Daniel; Sutton, Stephen; Seaman, Shaun R; White, Ian R

AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue

AMPK 激活可通过皮下白色脂肪组织中 Ucp1 独立的产热作用来预防饮食引起的肥胖

Alice E Pollard, Luís Martins, Phillip J Muckett, Sanjay Khadayate, Aurélie Bornot, Maryam Clausen, Therese Admyre, Mikael Bjursell, Rebeca Fiadeiro, Laura Wilson, Chad Whilding, Vassilios N Kotiadis, Michael R Duchen, Daniel Sutton, Lucy Penfold, Alessandro Sardini, Mohammad Bohlooly-Y, David M Smi

Psychological screening of adults and young people following the Manchester Arena incident

曼彻斯特体育馆事件后,对成年人和青少年进行心理筛查

French, Paul; Barrett, Alan; Allsopp, Kate; Williams, Richard; Brewin, Chris R; Hind, Daniel; Sutton, Rebecca; Stancombe, John; Chitsabesan, Prathiba

Spatiotemporal competition and task-relevance shape the spatial distribution of emotional interference during rapid visual processing: Evidence from gaze-contingent eye-tracking

时空竞争和任务相关性影响快速视觉处理过程中情绪干扰的空间分布:来自注视依赖性眼动追踪的证据

Kennedy, Briana L; Pearson, Daniel; Sutton, David J; Beesley, Tom; Most, Steven B