日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

泛素依赖性ATP酶p97从染色质中移除被捕获的、具有细胞毒性的PARP1。

Dragomir B Krastev # ,Shudong Li # ,Yilun Sun # ,Andrew J Wicks ,Gwendoline Hoslett ,Daniel Weekes ,Luned M Badder ,Eleanor G Knight ,Rebecca Marlow ,Mercedes Calvo Pardo ,Lu Yu ,Tanaji T Talele ,Jiri Bartek ,Jyoti S Choudhary ,Yves Pommier ,Stephen J Pettitt ,Andrew N J Tutt ,Kristijan Ramadan ,Christopher J Lord

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Sirtuin 抑制与 BRCA1 或 BRCA2 缺陷共同致死

Ilirjana Bajrami #, Callum Walker #, Dragomir B Krastev, Daniel Weekes, Feifei Song, Andrew J Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J Pettitt, Andrew N J Tutt, Christopher J Lord

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

综合基因组学和功能验证确定了三阴性乳腺癌中恶性细胞特异性依赖性

Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

基因组复杂性分析显示 HORMAD1 过表达导致三阴性乳腺癌同源重组缺陷

Johnathan Watkins, Daniel Weekes, Vandna Shah, Patrycja Gazinska, Shalaka Joshi, Bhavna Sidhu, Cheryl Gillett, Sarah Pinder, Fabio Vanoli, Maria Jasin, Markus Mayrhofer, Anders Isaksson, Maggie C U Cheang, Hasan Mirza, Jessica Frankum, Christopher J Lord, Alan Ashworth, Shaveta Vinayak, James M Ford

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

脱SUMOylase SENP7 促进染色质松弛,以进行同源重组 DNA 修复

Alexander J Garvin, Ruth M Densham, Sarah A Blair-Reid, Kenny M Pratt, Helen R Stone, Daniel Weekes, Kirsty J Lawrence, Joanna R Morris

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

蛋白酶体去泛素化酶 POH1 促进双链 DNA 断裂反应

Laura R Butler, Ruth M Densham, Junying Jia, Alexander J Garvin, Helen R Stone, Vandna Shah, Daniel Weekes, Frederic Festy, James Beesley, Joanna R Morris