日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis

白血病干细胞中 miR-142 获得性缺陷足以导致慢性粒细胞白血病进入急变期

Bin Zhang #, Dandan Zhao #, Fang Chen #, David Frankhouser, Huafeng Wang, Khyatiben V Pathak, Lei Dong, Anakaren Torres, Krystine Garcia-Mansfield, Yi Zhang, Dinh Hoa Hoang, Min-Hsuan Chen, Shu Tao, Hyejin Cho, Yong Liang, Danilo Perrotti, Sergio Branciamore, Russell Rockne, Xiwei Wu, Lucy Ghoda, Li

PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3β-Mediated c-Myc and Pim-1 Proteasomal Degradation

PP2A 激活药物通过 AKT 抑制依赖的 GSK-3β 介导的 c-Myc 和 Pim-1 蛋白酶体降解增强 FLT3 抑制剂的功效

Mario Scarpa, Prerna Singh, Christopher M Bailey, Jonelle K Lee, Shivani Kapoor, Rena G Lapidus, Sandrine Niyongere, Jaya Sangodkar, Yin Wang, Danilo Perrotti, Goutham Narla, Maria R Baer

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

miR-126在骨髓微环境中的转运调控慢性粒细胞白血病中白血病干细胞的自我更新

Bin Zhang ,Le Xuan Truong Nguyen ,Ling Li ,Dandan Zhao ,Bijender Kumar ,Herman Wu ,Allen Lin ,Francesca Pellicano ,Lisa Hopcroft ,Yu-Lin Su ,Mhairi Copland ,Tessa L Holyoake ,Calvin J Kuo ,Ravi Bhatia ,David S Snyder ,Haris Ali ,Anthony S Stein ,Casey Brewer ,Huafeng Wang ,Tinisha McDonald ,Piotr Swiderski ,Estelle Troadec ,Ching-Cheng Chen ,Adrienne Dorrance ,Vinod Pullarkat ,Yate-Ching Yuan ,Danilo Perrotti ,Nadia Carlesso ,Stephen J Forman ,Marcin Kortylewski ,Ya-Huei Kuo ,Guido Marcucci

Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation

同时抑制 Pim 和 FLT3 激酶可增加 Mcl-1 蛋白酶体降解,从而促进 FLT3-ITD 急性髓系白血病细胞凋亡

Shivani Kapoor, Karthika Natarajan, Patrick R Baldwin, Kshama A Doshi, Rena G Lapidus, Trevor J Mathias, Mario Scarpa, Rossana Trotta, Eduardo Davila, Manfred Kraus, Dennis Huszar, Adriana E Tron, Danilo Perrotti, Maria R Baer

Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia

利用 miR-181a 靶向治疗急性髓系白血病中的 RAS/MAPK 通路

Xiaomeng Huang, Sebastian Schwind, Ramasamy Santhanam, Ann-Kathrin Eisfeld, Chi-Ling Chiang, Malori Lankenau, Bo Yu, Pia Hoellerbauer, Yan Jin, Somayeh S Tarighat, Jihane Khalife, Alison Walker, Danilo Perrotti, Clara D Bloomfield, Hongyan Wang, Robert J Lee, Ly James Lee, Guido Marcucci

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

生长因子受体介导的 JAK2 信号在人类急性髓系白血病干细胞生长和维持中的作用

Amy M Cook, Liang Li, Yinwei Ho, Allen Lin, Ling Li, Anthony Stein, Stephen Forman, Danilo Perrotti, Richard Jove, Ravi Bhatia

Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway

BAALC 内的 Intronic miR-3151 通过解除 TP53 通路调控白血病形成

Ann-Kathrin Eisfeld, Sebastian Schwind, Ravi Patel, Xiaomeng Huang, Ramasamy Santhanam, Christopher J Walker, Joseph Markowitz, Kevin W Hoag, Tiina M Jarvinen, Benjamin Leffel, Danilo Perrotti, William E Carson 3rd, Guido Marcucci, Clara D Bloomfield #, Albert de la Chapelle #

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

Silvestrol 在体内和体外均表现出显著的抗白血病活性,并抑制急性髓系白血病中的 FLT3 和 miR-155 表达

Houda Alachkar, Ramasamy Santhanam, Jason G Harb, David M Lucas, Joshua J Oaks, Christopher J Hickey, Li Pan, A Douglas Kinghorn, Michael A Caligiuri, Danilo Perrotti, John C Byrd, Ramiro Garzon, Michael R Grever, Guido Marcucci

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia

来那度胺介导的 C/EBPα-p30 蛋白翻译增强上调急性髓系白血病中抗白血病 microRNA-181a 的表达

Christopher J Hickey, Sebastian Schwind, Hanna S Radomska, Adrienne M Dorrance, Ramasamy Santhanam, Anjali Mishra, Yue-Zhong Wu, Houda Alachkar, Kati Maharry, Deedra Nicolet, Krzysztof Mrózek, Alison Walker, Anna M Eiring, Susan P Whitman, Heiko Becker, Danilo Perrotti, Lai-Chu Wu, Xi Zhao, Todd A F

Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia

转铁蛋白结合阴离子脂多糖复合物纳米粒子靶向递送 microRNA-29b:急性髓系白血病的新型治疗策略

Xiaomeng Huang, Sebastian Schwind, Bo Yu, Ramasamy Santhanam, Hongyan Wang, Pia Hoellerbauer, Alice Mims, Rebecca Klisovic, Alison R Walker, Kenneth K Chan, William Blum, Danilo Perrotti, John C Byrd, Clara D Bloomfield, Michael A Caligiuri, Robert J Lee, Ramiro Garzon, Natarajan Muthusamy, Ly James