日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells.

利用 CRISPR 激活技术快速评估人类多能干细胞中的基因编辑产物

Wu Youjun, Zhong Aaron, Evangelisti Alessandro, Sidharta Mega, Danwei Huangfu, Studer Lorenz, Zhou Ting

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

平行基因组规模的 CRISPR-Cas9 筛选将人类多能干细胞身份与适应性区分开来

Bess P Rosen, Qing V Li, Hyein S Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R Damodaran, Hanuman T Kale, Samuel J Kaplan, Michael A Beer, Simone Sidoli, Danwei Huangfu

CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant

CRISPR筛选发现胰腺分化过程中ONECUT1的长程增强子,并将其与糖尿病风险变异体联系起来。

Samuel Joseph Kaplan ,Wilfred Wong ,Jielin Yan ,Julian Pulecio ,Hyein S Cho ,Qianzi Li ,Jiahui Zhao ,Jayanti Leslie-Iyer ,Jonathan Kazakov ,Dylan Murphy ,Renhe Luo ,Kushal K Dey ,Effie Apostolou ,Christina S Leslie ,Danwei Huangfu

Glucose Transporters Are Key Components of the Human Glucostat

葡萄糖转运蛋白是人体血糖调节器的关键组成部分

Inbal Caspi, Daniel M Tremmel, Julian Pulecio, Dapeng Yang, Dingyu Liu, Jielin Yan, Jon S Odorico, Danwei Huangfu

Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

动态网络引导的 CRISPRi 筛选可识别细胞状态转换期间 CTCF 环约束的非线性增强子基因调控活性

Renhe Luo, Jielin Yan, Jin Woo Oh, Wang Xi, Dustin Shigaki, Wilfred Wong, Hyein S Cho, Dylan Murphy, Ronald Cutler, Bess P Rosen, Julian Pulecio, Dapeng Yang, Rachel A Glenn, Tingxu Chen, Qing V Li, Thomas Vierbuchen, Simone Sidoli, Effie Apostolou, Danwei Huangfu, Michael A Beer

MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state

MLL3 缺失通过促进混合型上皮-间质转化状态驱动转移

Jihong Cui ,Chi Zhang ,Ji-Eun Lee ,Boris A Bartholdy ,Dapeng Yang ,Yu Liu ,Piril Erler ,Phillip M Galbo Jr ,Dayle Q Hodge ,Danwei Huangfu ,Deyou Zheng ,Kai Ge ,Wenjun Guo

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation

Pold1 的次等位基因突变破坏了原肠胚形成过程中胚胎尺寸扩张和形态发生的协调

Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V Anderson

Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation

人类心脏分化过程中 TET 酶对 DNA 甲基化的阶段性调控

Yahui Lan, Kelly M Banks, Heng Pan, Nipun Verma, Gary R Dixon, Ting Zhou, Bo Ding, Olivier Elemento, Shuibing Chen, Danwei Huangfu, Todd Evans

Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors

建立人类胚胎干细胞模型,利用 EWSR1-CREB 融合混杂性作为人类肿瘤的常见转化途径

Fabio Vanoli, Brigita Meskauskaite, Laurie Herviou, William Mallen, Yun-Shao Sung, Yumi Fujisawa, Lei Zhang, Steven Simon, Danwei Huangfu, Maria Jasin, Cristina R Antonescu

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation

基因组规模筛选发现 JNK-JUN 信号通路是多能性退出和内胚层分化的障碍。

Qing V Li ,Gary Dixon ,Nipun Verma ,Bess P Rosen ,Miriam Gordillo ,Renhe Luo ,Chunlong Xu ,Qiong Wang ,Chew-Li Soh ,Dapeng Yang ,Miguel Crespo ,Abhijit Shukla ,Qing Xiang ,Friederike Dündar ,Paul Zumbo ,Matthew Witkin ,Richard Koche ,Doron Betel ,Shuibing Chen ,Joan Massagué ,Ralph Garippa ,Todd Evans ,Michael A Beer ,Danwei Huangfu