AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRAS(G12C) mutation colorectal cancer liver metastasis.
AKR1B10 通过组蛋白乳酸化重编程中性粒细胞，从而促进 KRAS(G12C) 突变结直肠癌肝转移的免疫逃逸。
期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03653-2
Li Weiwei, Yuan Wenkang, Du Zihao, Wang Xiangyu, Wang Daoyue, Xing Songlin, Shen Tingting, Lu Canliang, Chen Jiale, Yu Anhai, Jiang Xinyu, Zhang Shiwei, Zheng Shuhao, Feng Xiaowen, Wang Tianqi, Zuo Jieliang, Chen Jinhong, Zhang Chao, Wang Xuefu, Zhang Chong
肿瘤
肠癌
中性粒细胞
肿瘤免疫
粒细胞
乳酸化
细胞生物学
RAS
免疫/内分泌
