日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AOC 1044 induces exon 44 skipping and restores dystrophin protein in preclinical models of Duchenne muscular dystrophy.

AOC 1044 可诱导外显子 44 跳跃,并在杜氏肌营养不良症的临床前模型中恢复肌营养不良蛋白

Etxaniz Usue, Marks Isaac, Albin Tyler, Diaz Matthew, Bhardwaj Raghav, Anderson Aaron, Tyaglo Olecya, Hoang Tiffany, Missinato Maria Azzurra, Svensson Kristoffer, Badillo Ben, Kovach Philip R, Leung Laura, Cochran Michael, Kwon Hae Won, Ahad Shah Md Nur, Maruyama Rika, Yokota Toshifumi, Doppalapudi Venkata R, Darimont Beatrice, Younis Husam S, Flanagan W Michael, Levin Arthur A, Huang Hanhua, Karamanlidis Georgios

Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs)

利用抗体-寡核苷酸偶联物(AOCs)进行RNA疗法的靶向组织递送

Malecova, Barbora; Burke, Rob S; Cochran, Michael; Hood, Michael D; Johns, Rachel; Kovach, Philip R; Doppalapudi, Venkata R; Erdogan, Gulin; Arias, J Danny; Darimont, Beatrice; Miller, Christopher D; Huang, Hanhua; Geall, Andrew; Younis, Husam S; Levin, Arthur A

Correction: The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

更正:选择性雌激素受体下调剂 GDC-0810 在多种 ER+ 乳腺癌模型中均有效。

Joseph, James D; Darimont, Beatrice; Zhou, Wei; Arrazate, Alfonso; Young, Amy; Ingalla, Ellen; Walter, Kimberly; Blake, Robert A; Nonomiya, Jim; Guan, Zhengyu; Kategaya, Lorna; Govek, Steven P; Lai, Andiliy G; Kahraman, Mehmet; Brigham, Dan; Sensintaffar, John; Lu, Nhin; Shao, Gang; Qian, Jing; Grillot, Kate; Moon, Michael; Prudente, Rene; Bischoff, Eric; Lee, Kyoung-Jin; Bonnefous, Celine; Douglas, Karensa L; Julien, Jackaline D; Nagasawa, Johnny Y; Aparicio, Anna; Kaufman, Josh; Haley, Benjamin; Giltnane, Jennifer M; Wertz, Ingrid E; Lackner, Mark R; Nannini, Michelle A; Sampath, Deepak; Schwarz, Luis; Manning, Henry Charles; Tantawy, Mohammed Noor; Arteaga, Carlos L; Heyman, Richard A; Rix, Peter J; Friedman, Lori; Smith, Nicholas D; Metcalfe, Ciara; Hager, Jeffrey H

ARN-509: a novel antiandrogen for prostate cancer treatment

ARN-509:一种用于治疗前列腺癌的新型抗雄激素

Clegg, Nicola J; Wongvipat, John; Joseph, James D; Tran, Chris; Ouk, Samedy; Dilhas, Anna; Chen, Yu; Grillot, Kate; Bischoff, Eric D; Cai, Ling; Aparicio, Anna; Dorow, Steven; Arora, Vivek; Shao, Gang; Qian, Jing; Zhao, Hong; Yang, Guangbin; Cao, Chunyan; Sensintaffar, John; Wasielewska, Teresa; Herbert, Mark R; Bonnefous, Celine; Darimont, Beatrice; Scher, Howard I; Smith-Jones, Peter; Klang, Mark; Smith, Nicholas D; De Stanchina, Elisa; Wu, Nian; Ouerfelli, Ouathek; Rix, Peter J; Heyman, Richard A; Jung, Michael E; Sawyers, Charles L; Hager, Jeffrey H

An F-domain introduced by alternative splicing regulates activity of the zebrafish thyroid hormone receptor alpha.

通过选择性剪接引入的 F 结构域调节斑马鱼甲状腺激素受体 α 的活性

Takayama Sachiko, Hostick Ute, Haendel Melissa, Eisen Judith, Darimont Beatrice

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

糖皮质激素受体对转录调控表面的靶向特异性利用

Rogatsky, Inez; Wang, Jen-Chywan; Derynck, Mika K; Nonaka, Daisuke F; Khodabakhsh, Daniel B; Haqq, Christopher M; Darimont, Beatrice D; Garabedian, Michael J; Yamamoto, Keith R