日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

口服核苷类似物奥贝地西韦对非洲绿猴的呼吸道合胞病毒感染有效。

Jared Pitts #,J Lizbeth Reyes Zamora #,Savrina Manhas,Thomas Aeschbacher,Josolyn Chan,Vincent Cutillas,Varsha Nair,Nicholas C Riola,Arya Vijjapurapu,Meghan S Vermillion,Stacey Eng,Christopher Richards,Dong Han,Jason K Perry,Subhra Chaudhuri,Szu-Wen Liu,Clarissa Martinez,Nadine Peinovich,Kai-Hui Sun,Arthur Cai,Ross Martin,Jasmine Moshiri,Charlotte Hedskog,Darius Babusis,Dustin S Siegel,Rao Kalla,Vasanthi Avadhanula,Pedro A Piedra,Kim Stobbelaar,Peter L Delputte,Caleb Marceau,Roberto Mateo,Evguenia Maiorova,Hongmei Mo,Raju Subramanian,Richard L Mackman,Tomas Cihlar,Simon P Fletcher,John P Bilello

A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology

HPIV-3 感染的稳健小鼠模型以及 GS-441524 对病毒诱发的肺部病理的疗效

Yuxia Lin, Mona Khan, Birgit Weynand, Manon Laporte, Frank Coenjaerts, Darius Babusis, John P Bilello, Peter Mombaerts, Dirk Jochmans, Johan Neyts

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

发现 GS-5245(奥贝地西韦),这是核苷 GS-441524 的口服前药,对感染 SARS-CoV-2 的非洲绿猴具有抗病毒功效

Richard L Mackman, Rao V Kalla, Darius Babusis, Jared Pitts, Kimberly T Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B Michael O'Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Kassibla Elodie Dempah, Elaine Bunya

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

使用瑞德西韦母体核苷的口服前药进行治疗可预防小鼠感染 SARS-CoV-2

Alexandra Schäfer, David R Martinez, John J Won, Rita M Meganck, Fernando R Moreira, Ariane J Brown, Kendra L Gully, Mark R Zweigart, William S Conrad, Samantha R May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T B

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

吸入瑞德西韦可减轻非人类灵长类动物 SARS-CoV-2 感染模型中的病毒负担

Meghan S Vermillion, Eisuke Murakami, Bin Ma, Jared Pitts, Adrian Tomkinson, Davin Rautiola, Darius Babusis, Hammad Irshad, Dustin Seigel, Cynthia Kim, Xiaofeng Zhao, Congrong Niu, Jesse Yang, Andrew Gigliotti, Nani Kadrichu, John P Bilello, Scott Ellis, Roy Bannister, Raju Subramanian, Bill Smith, 

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

核苷/核苷酸类似物替诺福韦和恩曲他滨对 SARS-CoV-2 无效

Joy Y Feng, Venice Du Pont, Darius Babusis, Calvin J Gordon, Egor P Tchesnokov, Jason K Perry, Vincent Duong, Arya Vijjapurapu, Xiaofeng Zhao, Julie Chan, Cal Cohen, Kavita Juneja, Tomas Cihlar, Matthias Götte, John P Bilello

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

瑞德西韦母体 GS-441524 的口服前药对雪貂中的 SARS-CoV-2 有效

Robert M Cox, Josef D Wolf, Carolin M Lieber, Julien Sourimant, Michelle J Lin, Darius Babusis, Venice DuPont, Julie Chan, Kim T Barrett, Diane Lye, Rao Kalla, Kwon Chun, Richard L Mackman, Chengjin Ye, Tomas Cihlar, Luis Martinez-Sobrido, Alexander L Greninger, John P Bilello, Richard K Plemper

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

脱靶体外分析表明瑞德西韦是一种高选择性抗病毒药物

Yili Xu, Ona Barauskas, Cynthia Kim, Darius Babusis, Eisuke Murakami, Dmytro Kornyeyev, Gary Lee, George Stepan, Michel Perron, Roy Bannister, Brian E Schultz, Roman Sakowicz, Danielle Porter, Tomas Cihlar, Joy Y Feng

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

参与瑞德西韦在人肺细胞中激活的关键代谢酶

Ruidong Li #, Albert Liclican #, Yili Xu, Jared Pitts, Congrong Niu, Jingyu Zhang, Cynthia Kim, Xiaofeng Zhao, Daniel Soohoo, Darius Babusis, Qin Yue, Bin Ma, Bernard P Murray, Raju Subramanian, Xuping Xie, Jing Zou, John P Bilello, Li Li, Brian E Schultz, Roman Sakowicz, Bill J Smith, Pei-Yong Shi,

Two-dose emtricitabine/tenofovir alafenamide plus bictegravir prophylaxis protects macaques against SHIV infection

两剂量恩曲他滨/替诺福韦艾拉酚胺加比克替拉韦预防治疗可保护恒河猴免受 SHIV 感染

Elena Bekerman, Stephanie Cox, Darius Babusis, Federico Campigotto, Moupali Das, Dan H Barouch, Tomas Cihlar, Christian Callebaut