日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy

小分子抑制γ-谷氨酰羧化酶揭示了一种新型抗凝血策略

Shen, Guomin; Song, Dan; Li, Shixin; Chen, Xuejie; Richter, Catherine E; Dong, Shixia; Guo, Yiming; Liu, Hongli; Shen, Yan; Hao, Zhenyu; Stafford, Darrel W; Shavit, Jordan A; Cao, Qing; Tie, Jian-Ke

Blood bacterial DNA signatures in a prospective cohort of patients with MASLD cirrhosis

前瞻性队列研究中MASLD肝硬化患者的血液细菌DNA特征

Kwan, Suet-Ying; Dolapchiev, Lillian I; Sanchez, Caren I; Calderone, Tiffany L; Sanchez, Jessica I; Bhongade, Megha B; El Sabagh, Ahmed; Cleere, Darrel W; Gupta, Nakul; Jalal, Prasun K; Victor, David W; Beretta, Laura

Metabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis

在一项前瞻性肝硬化患者队列研究中,代谢组学生物标志物与肝细胞癌的关联性研究。

Sanchez, Jessica I; Fontillas, Antoine C; Kwan, Suet-Ying; Sanchez, Caren I; Calderone, Tiffany L; Lee, Jana L; Elsaiey, Ahmed; Cleere, Darrel W; Wei, Peng; Vierling, John M; Victor, David W; Beretta, Laura

Dimensionality Reduction and Nearest Neighbors for Improving Out-of-Distribution Detection in Medical Image Segmentation

降维和最近邻算法在医学图像分割中提高分布外检测性能

Woodland, McKell; Patel, Nihil; Castelo, Austin; Taie, Mais Al; Eltaher, Mohamed; Yung, Joshua P; Netherton, Tucker J; Calderone, Tiffany L; Sanchez, Jessica I; Cleere, Darrel W; Elsaiey, Ahmed; Gupta, Nakul; Victor, David; Beretta, Laura; Patel, Ankit B; Brock, Kristy K

Assessment of gamma-glutamyl carboxylase activity in its native milieu.

在天然环境中评估γ-谷氨酰羧化酶的活性

Chen Xuejie, Stafford Darrel W, Tie Jian-Ke

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

全基因组 CRISPR-Cas9 基因敲除筛选鉴定出 FSP1 为华法林耐药性维生素 K 还原酶。

Da-Yun Jin ,Xuejie Chen ,Yizhou Liu ,Craig M Williams ,Lars C Pedersen ,Darrel W Stafford ,Jian-Ke Tie

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation

天然存在的UBIAD1突变对甲萘醌生物合成和维生素K依赖性羧化作用的影响各不相同。

Chen, Xuejie; Furukawa, Natsuko; Jin, Da-Yun; Liu, Yizhou; Stafford, Darrel W; Williams, Craig M; Suhara, Yoshitomo; Tie, Jian-Ke

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins

γ-谷氨酰羧化酶突变对维生素 K 依赖性蛋白质的生物学功能产生不同的影响

Zhenyu Hao, Da-Yun Jin, Xuejie Chen, Leon J Schurgers, Darrel W Stafford, Jian-Ke Tie

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase

一种新型维生素K衍生抗凝血剂,可耐受维生素K环氧化物还原酶的基因变异

Chen, Xuejie; Liu, Yizhou; Furukawa, Natsuko; Jin, Da-Yun; Paul Savage, G; Stafford, Darrel W; Suhara, Yoshitomo; Williams, Craig M; Tie, Jian-Ke

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

基于细胞的高通量筛选可通过偏离维生素 K 循环来识别引起出血性疾病的药物

Xuejie Chen, Caihong Li, Da-Yun Jin, Brian Ingram, Zhenyu Hao, Xue Bai, Darrel W Stafford, Keping Hu, Jian-Ke Tie