日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3

利用 pooled-AlphaFold3 预测自由生活细菌的蛋白质相互作用图谱

Todor, Horia; Kim, Lili M; Jänes, Jürgen; Burkhart, Hannah N; Darst, Seth A; Beltrao, Pedro; Gross, Carol A

KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid

KorB从DNA滑动钳转变为阻遏蛋白介导多药耐药质粒中的长程基因沉默

McLean, Thomas C; Balaguer-Pérez, Francisco; Chandanani, Joshua; Thomas, Christopher M; Aicart-Ramos, Clara; Burick, Sophia; Olinares, Paul Dominic B; Gobbato, Giulia; Mundy, Julia E A; Chait, Brian T; Lawson, David M; Darst, Seth A; Campbell, Elizabeth A; Moreno-Herrero, Fernando; Le, Tung B K

Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase

结核分枝杆菌RNA聚合酶从头启动子逃逸的结构解析

Brewer, Joshua; Delbeau, Madeleine; Zoullas, Winston Bates; Darst, Seth A; Campbell, Elizabeth A

Real-time capture of σ(N) transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding.

实时捕获σ(N)转录起始中间体揭示了ATPase驱动的有限展开激活机制

Mueller Andreas U, Molina Nina, Nixon B Tracy, Darst Seth A

Structural basis for loading of Transcription Repair-Coupling factor Mfd onto stalled elongation complexes

转录修复偶联因子Mfd加载到停滞延伸复合物上的结构基础

Brewer, Joshua; Llewellyn, Eliza; Chen, James; Campbell, Elizabeth A; Darst, Seth A

Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy.

利用时间分辨冷冻电镜观察细菌 RNA 聚合酶启动子熔解的早期中间体

Saecker Ruth M, Mueller Andreas U, Malone Brandon, Chen James, Budell William C, Dandey Venkata P, Maruthi Kashyap, Mendez Joshua H, Molina Nina, Eng Edward T, Yen Laura Y, Potter Clinton S, Carragher Bridget, Darst Seth A

The yin and yang of the universal transcription factor NusG

通用转录因子NusG的阴阳两面

Delbeau, Madeleine; Froom, Ruby; Landick, Robert; Darst, Seth A; Campbell, Elizabeth A

Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain.

SARS-CoV-2 NiRAN 结构域酶可塑性的结构和功能见解

Small Gabriel I, Fedorova Olga, Olinares Paul Dominic B, Chandanani Joshua, Banerjee Anoosha, Choi Young Joo, Molina Henrik, Chait Brian T, Darst Seth A, Campbell Elizabeth A

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

基本暂停转录复合物的一系列相互转化的构象创造了调控选项

Kang, Jin Young; Mishanina, Tatiana V; Bao, Yu; Chen, James; Llewellyn, Eliza; Liu, James; Darst, Seth A; Landick, Robert

A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance

冠状病毒nsp13解旋酶的突变会损害酶活性并赋予其对瑞德西韦的部分耐药性。

Grimes, Samantha L; Choi, Young J; Banerjee, Anoosha; Small, Gabriel; Anderson-Daniels, Jordan; Gribble, Jennifer; Pruijssers, Andrea J; Agostini, Maria L; Abu-Shmais, Alexandra; Lu, Xiaotao; Darst, Seth A; Campbell, Elizabeth; Denison, Mark R