日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The first molecular study of Cystoisospora belli and Cyclospora cayetanensis in HIV/AIDS patients from Northern Iran

伊朗北部 HIV/AIDS 患者体内贝氏囊孢子虫和卡耶坦环孢子虫的首次分子研究

Basirpour, Bahareh; Sadeghi, Mitra; Ramezanzadeh, Saba; Daryaee, Niloofar; Gholami, Shirzad; Hosseini, Seyed Abdollah; Ahmadpour, Ehsan; Daryani, Ahmad; Aghayan, Sargis A

Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy

发现具有增强选择性和细胞功效的新型布鲁顿酪氨酸激酶 PROTAC

Yi-Qian Li, William G Lannigan, Shabnam Davoodi, Fereidoon Daryaee, Ana Corrionero, Patricia Alfonso, Jose A Rodriguez-Santamaria, Nan Wang, John D Haley, Peter J Tonge

Evaluating the Impact of the Tyr158 pK(a) on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis

评估 Tyr158 pK(a) 对结核分枝杆菌烯酰-ACP还原酶 InhA 的作用机制和抑制作用的影响

Davoodi, Shabnam; Daryaee, Fereidoon; Iuliano, James N; Tolentino Collado, Jinnette; He, YongLe; Pollard, Alyssa C; Gil, Agnieszka A; Aramini, James M; Tonge, Peter J

Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity

乙酰辅酶A羧化酶异二价抑制剂:药物靶点停留时间和时间依赖性抗菌活性

Matthew T Cifone ,YongLe He ,Rajeswari Basu ,Nan Wang ,Shabnam Davoodi ,Lauren A Spagnuolo ,Yuanyuan Si ,Taraneh Daryaee ,Craig E Stivala ,Stephen G Walker ,Peter J Tonge

Impact of Target Turnover on the Translation of Drug-Target Residence Time to Time-Dependent Antibacterial Activity

靶标周转对药物靶标停留时间转化为时间依赖性抗菌活性的影响

Rajeswari Basu, Nan Wang, Sneha Basak, Fereidoon Daryaee, Mustufa Babar, Eleanor K Allen, Stephen G Walker, John D Haley, Peter J Tonge

Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix

揭示LOV结构域光遗传传感器的机制:谷氨酰胺杠杆诱导Jα螺旋的展开

Iuliano, James N; Collado, Jinnette Tolentino; Gil, Agnieszka A; Ravindran, Pavithran T; Lukacs, Andras; Shin, SeungYoun; Woroniecka, Helena A; Adamczyk, Katrin; Aramini, James M; Edupuganti, Uthama R; Hall, Christopher R; Greetham, Gregory M; Sazanovich, Igor V; Clark, Ian P; Daryaee, Taraneh; Toettcher, Jared E; French, Jarrod B; Gardner, Kevin H; Simmerling, Carlos L; Meech, Stephen R; Tonge, Peter J

Positron Emission Tomography Imaging with 2-[(18)F]F- p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response

利用 2-[(18)F]F-对氨基苯甲酸进行正电子发射断层扫描成像,可检测金黄色葡萄球菌感染并监测药物反应。

Zhang, Zhuo; Ordonez, Alvaro A; Wang, Hui; Li, Yong; Gogarty, Kayla R; Weinstein, Edward A; Daryaee, Fereidoon; Merino, Jonathan; Yoon, Grace E; Kalinda, Alvin S; Mease, Ronnie C; Iuliano, James N; Smith-Jones, Peter M; Jain, Sanjay K; Tonge, Peter J

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy

利用时间分辨红外光谱探测LOV光感受器激活动力学的变化

Iuliano, James N; Gil, Agnieszka A; Laptenok, Sergey P; Hall, Christopher R; Tolentino Collado, Jinnette; Lukacs, Andras; Hag Ahmed, Safaa A; Abyad, Jenna; Daryaee, Taraneh; Greetham, Gregory M; Sazanovich, Igor V; Illarionov, Boris; Bacher, Adelbert; Fischer, Markus; Towrie, Michael; French, Jarrod B; Meech, Stephen R; Tonge, Peter J

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

定量机制 PK/PD 模型直接将 Btk 靶向作用与体内疗效联系起来

Fereidoon Daryaee, Zhuo Zhang, Kayla R Gogarty, Yong Li, Jonathan Merino, Stewart L Fisher, Peter J Tonge

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase

抑制类鼻疽伯克霍尔德菌 FabI1 烯酰-ACP 还原酶的结合动力学合理化

Carla Neckles, Sandra Eltschkner, Jason E Cummings, Maria Hirschbeck, Fereidoon Daryaee, Gopal R Bommineni, Zhuo Zhang, Lauren Spagnuolo, Weixuan Yu, Shabnam Davoodi, Richard A Slayden, Caroline Kisker, Peter J Tonge