日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual-encoder contrastive learning accelerates enzyme discovery

双编码器对比学习加速酶的发现

Rocks, Jason W; Truong, Dat P; Rappoport, Dmitrij; Maddrell-Mander, Samuel; Martin-Alarcon, Daniel A; Lee, Toni M; Crossan, Steven; Goldford, Joshua E

Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes.

分子内上位性与混杂型和双功能 NSAR/OSBS 酶的特异性差异相关

Truong Dat P, Dharmatti Roopa, Suriadinata Dylan, Huddleston Jamison, Skouby Rebecca, Owusu Addo Gladys, Zhu Mingzhao, Acharige Anjana Delpe, Sankari Bayana Reethu, Davila Cristian, Fults Susan C, Raushel Frank M, Hull Kenneth G, Romo Daniel, Glasner Margaret E

Enhanced Prediction of Absorption and Emission Wavelengths of Organic Compounds through Hybrid Graph Neural Network Architectures

通过混合图神经网络架构增强对有机化合物吸收和发射波长的预测

Nguyen, Dat P; Le, Quyet M; Tran, Hoa T P; Le, Phuc T; Nguyen, Tin V T

Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94.

核 GRP78 转录调控活性及其与核 GRP94 相互作用的要求

Liu Ze, Ha Dat P, Lin Liangguang Leo, Qi Ling, Lee Amy S

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19

强心苷夹竹桃苷通过靶向抑制GRP78的应激诱导,可同时抑制癌症和COVID-19。

Dat P Ha #,Woo-Jin Shin #,Ze Liu #,Michael E Doche,Roy Lau,Nektaria Maria Leli,Crystal S Conn,Mariangela Russo,Annalisa Lorenzato,Constantinos Koumenis,Min Yu,Shannon M Mumenthaler,Amy S Lee

GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumors

GRP78 抑制剂 YUM70 上调 4E-BP1 并抑制 c-MYC 表达和致癌 c-MYC 肿瘤的活力

Vicky Yamamoto, Dat P Ha, Ze Liu, Miller Huang, Soma Samanta, Nouri Neamati, Amy S Lee

ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator

内质网分子伴侣GRP78/BiP在应激条件下易位至细胞核,并作为转录调节因子发挥作用。

Liu, Ze; Liu, Guanlin; Ha, Dat P; Wang, Justin; Xiong, Min; Lee, Amy S

GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage

GRP78 抑制剂 YUM70 可抑制 SARS-CoV-2 病毒入侵、刺突蛋白产生并改善肺损伤

Dat P Ha, Woo-Jin Shin, Juan Carlos Hernandez, Nouri Neamati, Louis Dubeau, Keigo Machida, Amy S Lee

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

应激诱导的内质网伴侣 GRP78/BiP 在 SARS-CoV-2 感染期间上调,并充当促病毒蛋白

Woo-Jin Shin #, Dat P Ha #, Keigo Machida, Amy S Lee

Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations

靶向 GRP78 可抑制致癌 KRAS 蛋白表达并降低携带各种 KRAS 突变的癌细胞的活力

Dat P Ha, Bo Huang, Han Wang, Daisy Flores Rangel, Richard Van Krieken, Ze Liu, Soma Samanta, Nouri Neamati, Amy S Lee