日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells.

BRCA1-A 复合物限制 ATM 缺陷细胞中依赖于复制叉逆转的 DNA 修复。

Datta Arindam, Jackson Jessica, Morozov Yaroslav I, Qiu Jinghan, Vindigni Alessandro, Greenberg Roger A

Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR

通过联合抑制PKMYT1和ATR靶向CCNE1扩增的卵巢癌和子宫内膜癌

Xu, Haineng; George, Erin; Gallo, David; Medvedev, Sergey; Wang, Xiaolei; Datta, Arindam; Kryczka, Rosie; Hyer, Marc L; Fourtounis, Jimmy; Stocco, Rino; Aguado-Fraile, Elia; Petrone, Adam; Yin, Shou Yun; Shiwram, Ariya; Liu, Fang; Anderson, Matthew; Kim, Hyoung; Greenberg, Roger A; Marshall, C Gary; Simpkins, Fiona

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.

抑制去泛素化酶活性和炎症信号的分子胶

Chandler Francesca, Reddy Poli Adi Narayana, Bhutda Smita, Ross Rebecca L, Datta Arindam, Walden Miriam, Walker Kieran, Di Donato Stefano, Cassel Joel A, Prakesch Michael A, Aman Ahmed, Datti Alessandro, Campbell Lisa J, Foglizzo Martina, Bell Lillie, Stein Daniel N, Ault James R, Al-Awar Rima S, Calabrese Antonio N, Sicheri Frank, Del Galdo Francesco, Salvino Joseph M, Greenberg Roger A, Zeqiraj Elton

53BP1 condensates function as bioreactors for NHEJ directed DNA repair and insulators to determine pathway choice

53BP1 凝聚物作为生物反应器,参与 NHEJ 介导的 DNA 修复,并作为绝缘体决定修复途径的选择。

Garabedian, Mikael V; Zhang, Tianpeng; Datta, Arindam; Wang, Wentao; Wadley, Maxwell; Greenberg, Roger A; Good, Matthew C

Replication stress as a driver of cellular senescence and aging

复制压力是细胞衰老和老化的驱动因素

Herr, Lauren M; Schaffer, Ethan D; Fuchs, Kathleen F; Datta, Arindam; Brosh, Robert M Jr

Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease

新发现的遗传性RECQ解旋酶疾病RECON综合征表明,复制应激反应和基因组稳态是衰老和年龄相关疾病的核心重要过程。

Datta, Arindam; Sommers, Joshua A; Jhujh, Satpal S; Harel, Tamar; Stewart, Grant S; Brosh, Robert M Jr

WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer

WRN 可挽救因 BRCA2 缺陷而受损的复制叉:预测抑制一种抑制过早衰老的解旋酶如何使癌症中复制叉死亡和染色体不稳定的平衡向其倾斜

Datta, Arindam; Brosh, Robert M Jr

Synthetic Lethal Interactions of RECQ Helicases

RECQ解旋酶的合成致死相互作用

Datta, Arindam; Dhar, Srijita; Awate, Sanket; Brosh, Robert M Jr

G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology

核糖体DNA介导的G-四链体组装:在疾病发病机制和癌症生物学中的新兴作用

Datta, Arindam; Pollock, Kevin J; Kormuth, Karen A; Brosh, Robert M Jr

Holding All the Cards-How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability

掌握所有主动权——范可尼贫血症蛋白如何应对复制压力并维持基因组稳定性

Datta, Arindam; Brosh, Robert M Jr