David Sheila S相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

OGG1 and MUTYH DNA Glycosylases, the Dynamic Duo Against 8-Oxoguanine DNA Lesion: Structure, Regulation, and Novel Emerging Roles

OGG1 和 MUTYH DNA 糖基化酶：对抗 8-氧鸟嘌呤 DNA 损伤的动态二人组：结构、调控和新兴作用

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom16020257

Gómez-Ramírez, Ana P; Malek, Melody; García-González, Estela G; Campos, Sergio E; Brieba, Luis G; David, Sheila S; Trasviña-Arenas, Carlos H

发表日期：2026

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MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repair

MUTYH 癌症相关变异体位于域间连接区，对糖基化酶活性和细胞 DNA 修复产生不同的影响。

doi:10.64898/2026.03.03.709415

Khuu, Cindy; Malek, Melody; Conlon, Savannah G; Wadey, Geoffrey P; Trasviña-Arenas, Carlos H; David, Sheila S

细胞生物学

发表日期：2026

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Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY

腺嘌呤DNA糖基化酶MutY激活核碱基的结构基础

doi:10.64898/2026.01.22.701053

Russelburg, L Peyton; Demir, Merve; Cedeno, Karina; David, Sheila S; Horvath, Martin P

发表日期：2026

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Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.

人类 MUTYH 的结构和癌症相关变体的功能分析揭示了其 [4Fe-4S] 簇辅因子和 DNA 修复所需的活性位点之间的变构网络

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-58361-w

TrasviÃ±a-Arenas Carlos H, Dissanayake Upeksha C, Tamayo Nikole, Hashemian Mohammad, Lin Wen-Jen, Demir Merve, Hoyos-Gonzalez Nallely, Fisher Andrew J, Cisneros G AndrÃ©s, Horvath Martin P, David Sheila S

发表日期：2025

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Crystal structure of MutYX: a novel clusterless adenine DNA glycosylase with a distinct C-terminal domain and 8-oxoguanine recognition sphere

MutYX的晶体结构：一种新型的无簇腺嘌呤DNA糖基化酶，具有独特的C端结构域和8-氧鸟嘌呤识别球

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaf1127

Trasviña-Arenas, Carlos H; Hashemian, Mohammad; Malek, Melody; Merrill, Steven; Fisher, Andrew J; David, Sheila S

发表日期：2025

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Designing Programmable Peptide Nucleic Acid-based Nanovaccines for Anticancer Immune Activation

设计可编程肽核酸纳米疫苗用于抗癌免疫激活

影响因子:12.1

doi:10.1002/smll.202505605

Huang, Yanyu; Huang, Cuiqing; Pandita, Sakshi; Ieong, Chon Man; Wang, Yongheng; Wang, David; Chen, Jifeng; Jauregui-Matos, Victorio; Beelen, Alessandra Maria Arabelle; Shiau, Ya-Ping; Tang, Shiqi; Zhao, Junwei; Zong, Qiufang; Tang, Menghuan; Cong, Zhaoqing; Li, Yuanpei; Beal, Peter A; David, Sheila S; Wang, Aijun; Wang, Duo; Xiao, Zeyu; Lam, Kit S

免疫/内分泌

发表日期：2025

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Structure, dynamics, and processing of 8oxoG:A in the nucleosome

核小体中8-氧鸟嘌呤的结构、动力学和加工

doi:10.1101/2025.09.02.673820

Vito, Abigayle F; Ling, Justin A; Ferrara, Julia C; Jacques, Caleb S; Gillet, Natacha; Gonzalez-Aleman, Roy; Qiu, Yuya; Hashemian, Mohammad; Trasvina-Arenas, Carlos H; David, Sheila S; Delaney, Sarah; Bignon, Emmanuelle; Freudenthal, Bret D

发表日期：2025

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FSHing for DNA Damage: Key Features of MutY Detection of 8-Oxoguanine:Adenine Mismatches

FSH检测DNA损伤：MutY检测8-氧鸟嘌呤:腺嘌呤错配的关键特征

期刊:Accounts of Chemical Research

影响因子:17.7

doi:10.1021/acs.accounts.3c00759

Majumdar, Chandrima; Demir, Merve; Merrill, Steven R; Hashemian, Mohammad; David, Sheila S

发表日期：2024

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Cellular Repair of Synthetic Analogs of Oxidative DNA Damage Reveals a Key Structure-Activity Relationship of the Cancer-Associated MUTYH DNA Repair Glycosylase

细胞对氧化性DNA损伤合成类似物的修复揭示了癌症相关MUTYH DNA修复糖基化酶的关键构效关系

期刊:ACS Central Science

影响因子:10.4

doi:10.1021/acscentsci.3c00784

Conlon, Savannah G; Khuu, Cindy; Trasviña-Arenas, Carlos H; Xia, Tian; Hamm, Michelle L; Raetz, Alan G; David, Sheila S

细胞生物学

发表日期：2024

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Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism

癌症相关变异体 MutY N146S 碱基切除的结构快照揭示了一种保留机制

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkac1246

Demir, Merve; Russelburg, L Peyton; Lin, Wen-Jen; Trasviña-Arenas, Carlos H; Huang, Beili; Yuen, Philip K; Horvath, Martin P; David, Sheila S

发表日期：2023

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