日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors

全身给药的TLR7/8激动剂和抗原偶联纳米凝胶调控抗肿瘤免疫反应

期刊:ACS Nano
影响因子:16
doi:10.1021/acsnano.1c10709
Stickdorn, Judith; Stein, Lara; Arnold-Schild, Danielle; Hahlbrock, Jennifer; Medina-Montano, Carolina; Bartneck, Joschka; Ziß, Tanja; Montermann, Evelyn; Kappel, Cinja; Hobernik, Dominika; Haist, Maximilian; Yurugi, Hajime; Raabe, Marco; Best, Andreas; Rajalingam, Krishnaraj; Radsak, Markus P; David, Sunil A; Koynov, Kaloian; Bros, Matthias; Grabbe, Stephan; Schild, Hansjörg; Nuhn, Lutz
肿瘤
肿瘤免疫
TLR7
信号转导
免疫/内分泌
发表日期：2022
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High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

由 Alhydroxyquim-II 佐剂三聚体刺突抗原诱导产生的针对 SARS-CoV-2 Delta 变异株的高滴度中和抗体

期刊:Microbiology Spectrum
影响因子:3.8
doi:10.1128/spectrum.01695-21
Counoupas, Claudio; Pino, Paco; Stella, Alberto O; Ashley, Caroline; Lukeman, Hannah; Bhattacharyya, Nayan D; Tada, Takuya; Anchisi, Stephanie; Metayer, Charles; Martinis, Jacopo; Aggarwal, Anupriya; Dcosta, Belinda M; Britton, Warwick J; Kint, Joeri; Wurm, Maria J; Landau, Nathaniel R; Steain, Megan; Turville, Stuart G; Wurm, Florian M; David, Sunil A; Triccas, James A
SARS-CoV-2
发表日期：2022
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Corrigendum: Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

更正：单次注射脂质两亲分子咪唑喹啉TLR7/8激动剂佐剂重组刺突蛋白疫苗可使小鼠获得针对SARS-CoV-2感染的完全免疫

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202105635
Jangra, Sonia; De Vrieze, Jana; Choi, Angela; Rathnasinghe, Raveen; Laghlali, Gabriel; Uvyn, Annemiek; Van Herck, Simon; Nuhn, Lutz; Deswarte, Kim; Zhong, Zifu; Sanders, Niek N; Lienenklaus, Stefan; David, Sunil A; Strohmeier, Shirin; Amanat, Fatima; Krammer, Florian; Hammad, Hamida; Lambrecht, Bart N; Coughlan, Lynda; García-Sastre, Adolfo; De Geest, Bruno G; Schotsaert, Michael
SARS-CoV-2
TLR7
炎症/感染
免疫/内分泌
发表日期：2021
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Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*

单次注射脂质两亲分子咪唑喹啉TLR7/8激动剂佐剂重组刺突蛋白疫苗可使小鼠获得针对SARS-CoV-2感染的完全免疫力*

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202015362
Jangra, Sonia; De Vrieze, Jana; Choi, Angela; Rathnasinghe, Raveen; Laghlali, Gabriel; Uvyn, Annemiek; Van Herck, Simon; Nuhn, Lutz; Deswarte, Kim; Zhong, Zifu; Sanders, Niek N; Lienenklaus, Stefan; David, Sunil A; Strohmeier, Shirin; Amanat, Fatima; Krammer, Florian; Hammad, Hamida; Lambrecht, Bart N; Coughlan, Lynda; García-Sastre, Adolfo; De Geest, Bruno G; Schotsaert, Michael
炎症/感染
SARS-CoV-2
TLR7
免疫/内分泌
发表日期：2021
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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

基于方酸酯的pH可降解纳米凝胶：用于安全、全身性给药Toll样受体7/8激动剂免疫调节剂的模块化纳米载体

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.1c03772
Huppertsberg, Anne; Kaps, Leonard; Zhong, Zifu; Schmitt, Sascha; Stickdorn, Judith; Deswarte, Kim; Combes, Francis; Czysch, Christian; De Vrieze, Jana; Kasmi, Sabah; Choteschovsky, Niklas; Klefenz, Adrian; Medina-Montano, Carolina; Winterwerber, Pia; Chen, Chaojian; Bros, Matthias; Lienenklaus, Stefan; Sanders, Niek N; Koynov, Kaloian; Schuppan, Detlef; Lambrecht, Bart N; David, Sunil A; De Geest, Bruno G; Nuhn, Lutz
信号转导
免疫/内分泌
发表日期：2021
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A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering

利用CRISPR工程技术设计多种SARS-CoV-2候选疫苗的通用噬菌体T4纳米颗粒平台

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.abh1547
Zhu, Jingen; Ananthaswamy, Neeti; Jain, Swati; Batra, Himanshu; Tang, Wei-Chun; Lewry, Douglass A; Richards, Michael L; David, Sunil A; Kilgore, Paul B; Sha, Jian; Drelich, Aleksandra; Tseng, Chien-Te K; Chopra, Ashok K; Rao, Venigalla B
SARS-CoV-2
发表日期：2021
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Lipid-Polyglutamate Nanoparticle Vaccine Platform

脂质-聚谷氨酸纳米颗粒疫苗平台

期刊:ACS Applied Materials & Interfaces
影响因子:8.2
doi:10.1021/acsami.0c20607
Van Lysebetten, Dorien; Malfanti, Alessio; Deswarte, Kim; Koynov, Kaloian; Golba, Bianka; Ye, Tingting; Zhong, Zifu; Kasmi, Sabah; Lamoot, Alexander; Chen, Yong; Van Herck, Simon; Lambrecht, Bart N; Sanders, Niek N; Lienenklaus, Stefan; David, Sunil A; Vicent, María J; De Koker, Stefaan; De Geest, Bruno G
发表日期：2021
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Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

酶响应性咪唑喹啉 TLR7/8 激动剂前药囊泡可强效且持久地激活先天免疫

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.0c01928
Wang, Bi; Van Herck, Simon; Chen, Yong; Bai, Xiangyang; Zhong, Zifu; Deswarte, Kim; Lambrecht, Bart N; Sanders, Niek N; Lienenklaus, Stefan; Scheeren, Hans W; David, Sunil A; Kiessling, Fabian; Lammers, Twan; De Geest, Bruno G; Shi, Yang
囊泡
TLR7
免疫/内分泌
发表日期：2020
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Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels

利用pH可降解聚降冰片烯纳米凝胶控制咪唑喹啉的免疫刺激作用

期刊:Biomacromolecules
影响因子:5.4
doi:10.1021/acs.biomac.0c00205
Kockelmann, Johannes; Stickdorn, Judith; Kasmi, Sabah; De Vrieze, Jana; Pieszka, Michaela; Ng, David Yuen W; David, Sunil A; De Geest, Bruno G; Nuhn, Lutz
免疫/内分泌
发表日期：2020
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Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides

二氢吡啶喹诺酮羧酰胺中人Toll样受体2激动活性的鉴定

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.8b00540
Hu, Ziwei; Banothu, Janardhan; Beesu, Mallesh; Gustafson, Collin J; Brush, Michael J H; Trautman, Kathryn L; Salyer, Alex C D; Pathakumari, Balaji; David, Sunil A
信号转导
Human
发表日期：2019
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