日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice

单次短期内皮细胞部分重编程可通过减弱高血压小鼠的内皮间质转化(EndMT)来降低血压

Laena Pernomian ,Emily W Waigi ,Vi Nguyen ,Ahmed D Mohammed ,Tiago J Costa ,Milene T Fontes ,Jason L Kubinak ,Andrew V Aitken ,Vinicia Campana Biancardi ,Kamryn Gleason ,Tarek Shazly ,David A Sinclair ,Cameron G McCarthy ,Yunguan Wang ,Wenbin Tan ,Camilla Ferreira Wenceslau

TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction

TIME-seq技术可降低构建表观遗传时钟所需的DNA甲基化测量时间和成本。

Patrick T Griffin ,Alice E Kane ,Alexandre Trapp ,Jien Li ,Matthew Arnold ,Jesse R Poganik ,Ryan J Conway ,Maeve S McNamara ,Margarita V Meer ,Noah Hoffman ,João A Amorim ,Xiao Tian ,Michael R MacArthur ,Sarah J Mitchell ,Amber L Mueller ,Colleen Carmody ,Daniel L Vera ,Csaba Kerepesi ,Kejun Ying ,Nicole Noren Hooten ,James R Mitchell ,Michele K Evans ,Vadim N Gladyshev ,David A Sinclair

Loss of epigenetic information as a cause of mammalian aging

表观遗传信息的丢失是哺乳动物衰老的原因之一

Jae-Hyun Yang ,Motoshi Hayano ,Patrick T Griffin ,João A Amorim ,Michael S Bonkowski ,John K Apostolides ,Elias L Salfati ,Marco Blanchette ,Elizabeth M Munding ,Mital Bhakta ,Yap Ching Chew ,Wei Guo ,Xiaojing Yang ,Sun Maybury-Lewis ,Xiao Tian ,Jaime M Ross ,Giuseppe Coppotelli ,Margarita V Meer ,Ryan Rogers-Hammond ,Daniel L Vera ,Yuancheng Ryan Lu ,Jeffrey W Pippin ,Michael L Creswell ,Zhixun Dou ,Caiyue Xu ,Sarah J Mitchell ,Abhirup Das ,Brendan L O'Connell ,Sachin Thakur ,Alice E Kane ,Qiao Su ,Yasuaki Mohri ,Emi K Nishimura ,Laura Schaevitz ,Neha Garg ,Ana-Maria Balta ,Meghan A Rego ,Meredith Gregory-Ksander ,Tatjana C Jakobs ,Lei Zhong ,Hiroko Wakimoto ,Jihad El Andari ,Dirk Grimm ,Raul Mostoslavsky ,Amy J Wagers ,Kazuo Tsubota ,Stephen J Bonasera ,Carlos M Palmeira ,Jonathan G Seidman ,Christine E Seidman ,Norman S Wolf ,Jill A Kreiling ,John M Sedivy ,George F Murphy ,Richard E Green ,Benjamin A Garcia ,Shelley L Berger ,Philipp Oberdoerffer ,Stuart J Shankland ,Vadim N Gladyshev ,Bruce R Ksander ,Andreas R Pfenning ,Luis A Rajman ,David A Sinclair

Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila

由同一转录本编码的两种神经元肽调控果蝇线粒体复合物III

Justin A Bosch ,Berrak Ugur ,Israel Pichardo-Casas ,Jordan Rabasco ,Felipe Escobedo ,Zhongyuan Zuo ,Ben Brown ,Susan Celniker ,David A Sinclair ,Hugo J Bellen ,Norbert Perrimon

Sirtuin Evolution at the Dawn of Animal Life

动物生命起源之初的Sirtuin进化

Gold, David A; Sinclair, David A

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

Sirtuin 5 水平在维持心脏功能和抑制压力超负荷引起的纤维化方面具有限制作用

Angela H Guo, Rachael Baliira, Mary E Skinner, Surinder Kumar, Anthony Andren, Li Zhang, Robert S Goldsmith, Shaday Michan, Norma J Davis, Merissa W Maccani, Sharlene M Day, David A Sinclair, Matthew J Brody, Costas A Lyssiotis, Adam B Stein, David B Lombard

Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography

采用优化的聚合物沉淀和尺寸排阻色谱法分离的细胞外囊泡亚群的定量蛋白质组学分析

Juan A Martínez-Greene, Karina Hernández-Ortega, Ricardo Quiroz-Baez, Osbaldo Resendis-Antonio, Israel Pichardo-Casas, David A Sinclair, Bogdan Budnik, Alfredo Hidalgo-Miranda, Eileen Uribe-Querol, María Del Pilar Ramos-Godínez, Eduardo Martínez-Martínez

Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung

细胞外囊泡用于治疗肺部放射引起的正常组织毒性

Pierre Montay-Gruel, Yafeng Zhu, Benoit Petit, Ron Leavitt, Mike Warn, Erich Giedzinski, Jonathan Ollivier, David A Sinclair, Marie-Catherine Vozenin, Charles L Limoli

Hippocampal state transitions at the boundaries between trial epochs

海马体在试验阶段边界处的状态转换

Bulkin, David A; Sinclair, David G; Law, L Matthew; Smith, David M

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

可溶性腺苷酸环化酶抑制剂 LRE1 通过改善线粒体功能预防肝脏缺血/再灌注损伤

João S Teodoro, João A Amorim, Ivo F Machado, Ana C Castela, Clemens Steegborn, David A Sinclair, Anabela P Rolo, Carlos M Palmeira