日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells

当代抗逆转录病毒疗法会扰乱铁转运并加剧 HIV 感染的人类小胶质细胞和神经谱系细胞的线粒体功能障碍

Harpreet Kaur ,Paige Minchella ,David Alvarez-Carbonell ,Neeraja Purandare ,Vijay K Nagampalli ,Daniel Blankenberg ,Todd Hulgan ,Mariana Gerschenson ,Jonathan Karn ,Siddhesh Aras ,Asha R Kallianpur

Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells

神经生长因子 IB 样受体 (Nurr1/NR4A2) 募集 CoREST 转录抑制复合物介导小胶质细胞中 HIV 的沉默

Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Sheetal Sreeram, Saba Valadkhan, Jonathan Karn

Targeting Nitric Oxide Production in Microglia with Novel Imidazodiazepines for Nonsedative Pain Treatment

利用新型咪唑二氮杂卓类药物靶向小胶质细胞中一氧化氮的产生,实现非镇静性镇痛治疗

Amanda N Nieman ,Guanguan Li ,Nicolas M Zahn ,Md Yeunus Mian ,Brandon N Mikulsky ,Dylan A Hoffman ,Taylor M Wilcox ,Alexander S Kehoe ,Ian W Luecke ,Michael M Poe ,David Alvarez-Carbonell ,James M Cook ,Douglas C Stafford ,Leggy A Arnold

Cross-talk between microglia and neurons regulates HIV latency

小胶质细胞和神经元之间的串扰调节艾滋病毒潜伏期

David Alvarez-Carbonell, Fengchun Ye, Nirmala Ramanath, Yoelvis Garcia-Mesa, Pamela E Knapp, Kurt F Hauser, Jonathan Karn

The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells

糖皮质激素受体是人类小胶质细胞中 HIV 潜伏期的关键调节因子

David Alvarez-Carbonell, Fengchun Ye, Nirmala Ramanath, Curtis Dobrowolski, Jonathan Karn

CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells

CRISPR-Cas9 介导的 TSPO 基因敲除改变了人类原代小胶质细胞的呼吸和细胞代谢

Vladimir M Milenkovic, Dounia Slim, Stefanie Bader, Victoria Koch, Elena-Sofia Heinl, David Alvarez-Carbonell, Caroline Nothdurfter, Rainer Rupprecht, Christian H Wetzel

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency

在重组人源化小鼠模型中研究HIV-1感染小胶质细胞,并鉴定选择性逆转HIV潜伏期的化合物

George N Llewellyn ,David Alvarez-Carbonell ,Morgan Chateau ,Jonathan Karn ,Paula M Cannon

Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells

Toll 样受体 3 的激活选择性地逆转小胶质细胞中的 HIV 潜伏期

David Alvarez-Carbonell, Yoelvis Garcia-Mesa, Stephanie Milne, Biswajit Das, Curtis Dobrowolski, Roxana Rojas, Jonathan Karn

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

原代小胶质细胞永生化:研究中枢神经系统中HIV调控的新平台

Yoelvis Garcia-Mesa ,Taylor R Jay ,Mary Ann Checkley ,Benjamin Luttge ,Curtis Dobrowolski ,Saba Valadkhan ,Gary E Landreth ,Jonathan Karn ,David Alvarez-Carbonell