日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An in vivo platform to select and evolve aggregation-resistant proteins

选择和进化抗聚集蛋白的体内平台

Jessica S Ebo #, Janet C Saunders #, Paul W A Devine, Alice M Gordon, Amy S Warwick, Bob Schiffrin, Stacey E Chin, Elizabeth England, James D Button, Christopher Lloyd, Nicholas J Bond, Alison E Ashcroft, Sheena E Radford, David C Lowe, David J Brockwell

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1

发现并表征选择性调节纤溶酶原激活剂抑制剂-1 抑制活性的抗体

Katherine A Vousden, Tomas Lundqvist, Bojana Popovic, Brian Naiman, Alan M Carruthers, Philip Newton, Daniel J D Johnson, Anja Pomowski, Trevor Wilkinson, Patrick Dufner, Isabelle de Mendez, Philip R Mallinder, Clare Murray, Martin Strain, Jane Connor, Lynne A Murray, Matthew A Sleeman, David C Lowe

Inducing protein aggregation by extensional flow

通过拉伸流动诱导蛋白质聚集

John Dobson, Amit Kumar, Leon F Willis, Roman Tuma, Daniel R Higazi, Richard Turner, David C Lowe, Alison E Ashcroft, Sheena E Radford, Nikil Kapur, David J Brockwell

A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors

人类 IgG1 同种异型 G1m3 和 G1m1,17 刺激同种异型匹配和不匹配供体的 T 细胞应答的能力比较

Carl I Webster, Christine J Bryson, Edward A Cloake, Tim D Jones, Mark J Austin, Anette C Karle, Sebastian Spindeldreher, David C Lowe, Matthew P Baker

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

IL-33报警素的氧化调节ST2依赖性炎症

E Suzanne Cohen,Ian C Scott,Jayesh B Majithiya,Laura Rapley,Benjamin P Kemp,Elizabeth England,D Gareth Rees,Catherine L Overed-Sayer,Joanne Woods,Nicholas J Bond,Christel Séguy Veyssier,Kevin J Embrey,Dorothy A Sims,Michael R Snaith,Katherine A Vousden,Martin D Strain,Denice T Y Chan,Sara Carmen,Catherine E Huntington,Liz Flavell,Jianqing Xu,Bojana Popovic,Christopher E Brightling,Tristan J Vaughan,Robin Butler,David C Lowe,Daniel R Higazi,Dominic J Corkill,Richard D May,Matthew A Sleeman,Tomas Mustelin

Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1

针对 A 类 GPCR 甲酰肽受体 1 的具有长 VH CDR3 的新型拮抗性人单克隆抗体的亲和力成熟

Julie A Douthwaite, Sudharsan Sridharan, Catherine Huntington, Jayne Hammersley, Rose Marwood, Jonna K Hakulinen, Margareta Ek, Tove Sjögren, David Rider, Cyril Privezentzev, Jonathan C Seaman, Peter Cariuk, Vikki Knights, Joyce Young, Trevor Wilkinson, Matthew Sleeman, Donna K Finch, David C Lowe, 

Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity

使用噬菌体和核糖体展示技术进行抗体 VH 和 VL 重组,揭示了亲和力改善的不同结构途径,其中 VH-VL 界面残基提供了重要的结构多样性

Maria A T Groves, Lily Amanuel, Jamie I Campbell, D Gareth Rees, Sudharsan Sridharan, Donna K Finch, David C Lowe, Tristan J Vaughan

Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure

单价 IgG4 分子:免疫球蛋白 Fc 突变导致单体结构

Ian C Wilkinson, Susan B Fowler, Leeann Machiesky, Kenneth Miller, David B Hayes, Morshed Adib, Cheng Her, M Jack Borrok, Ping Tsui, Matthew Burrell, Dominic J Corkill, Susanne Witt, David C Lowe, Carl I Webster

Open Data, Open Source and Open Standards in chemistry: The Blue Obelisk five years on

化学领域的开放数据、开源和开放标准:蓝色方尖碑项目五年回顾

O'Boyle, Noel M; Guha, Rajarshi; Willighagen, Egon L; Adams, Samuel E; Alvarsson, Jonathan; Bradley, Jean-Claude; Filippov, Igor V; Hanson, Robert M; Hanwell, Marcus D; Hutchison, Geoffrey R; James, Craig A; Jeliazkova, Nina; Lang, Andrew Sid; Langner, Karol M; Lonie, David C; Lowe, Daniel M; Pansanel, Jérôme; Pavlov, Dmitry; Spjuth, Ola; Steinbeck, Christoph; Tenderholt, Adam L; Theisen, Kevin J; Murray-Rust, Peter