日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

DLG1-ARHGAP31-CDC42轴对于肠道干细胞响应波动的微环境Wnt信号至关重要

David Castillo-Azofeifa ,Tomas Wald ,Efren A Reyes ,Aaron Gallagher ,Julia Schanin ,Stephanie Vlachos ,Nathalie Lamarche-Vane ,Carolyn Bomidi ,Sarah Blutt ,Mary K Estes ,Todd Nystul ,Ophir D Klein

Intracellular pH dynamics regulates intestinal stem cell lineage specification

细胞内pH动态变化调控肠道干细胞谱系分化。

Yi Liu ,Efren Reyes # ,David Castillo-Azofeifa # ,Ophir D Klein ,Todd Nystul ,Diane L Barber

Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis

上皮细胞TNF控制细胞分化和CFTR活性,以维持肠道黏蛋白稳态。

Efren A Reyes ,David Castillo-Azofeifa ,Jérémie Rispal ,Tomas Wald ,Rachel K Zwick ,Brisa Palikuqi ,Angela Mujukian ,Shervin Rabizadeh ,Alexander R Gupta ,James M Gardner ,Dario Boffelli ,Zev J Gartner ,Ophir D Klein

Cellular shape reinforces niche to stem cell signaling in the small intestine

细胞形状增强了小肠中干细胞信号传导的利基

Nalle Pentinmikko, Rodrigo Lozano, Sandra Scharaw, Simon Andersson, Johanna I Englund, David Castillo-Azofeifa, Aaron Gallagher, Martin Broberg, Ki-Young Song, Agustín Sola Carvajal, Alessondra T Speidel, Michael Sundstrom, Nancy Allbritton, Molly M Stevens, Ophir D Klein, Ana Teixeira, Pekka Kataji

Lgr5+ telocytes are a signaling source at the intestinal villus tip

Lgr5+端粒细胞是肠绒毛顶端的信号来源

Keren Bahar Halpern ,Hassan Massalha ,Rachel K Zwick ,Andreas E Moor ,David Castillo-Azofeifa ,Milena Rozenberg ,Lydia Farack ,Adi Egozi ,Dan R Miller ,Inna Averbukh ,Yotam Harnik ,Noa Weinberg-Corem ,Frederic J de Sauvage ,Ido Amit ,Ophir D Klein ,Michal Shoshkes-Carmel ,Shalev Itzkovitz

A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage

大量活跃增殖的祖细胞协调外胚层附属物的自我更新和损伤修复。

Amnon Sharir ,Pauline Marangoni # ,Rapolas Zilionis # ,Mian Wan ,Tomas Wald ,Jimmy K Hu ,Kyogo Kawaguchi ,David Castillo-Azofeifa ,Leo Epstein ,Kyle Harrington ,Pierfrancesco Pagella ,Thimios Mitsiadis ,Christian W Siebel ,Allon M Klein ,Ophir D Klein

Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration

在结肠再生过程中,Atoh1+分泌祖细胞具有不依赖于Lgr5+细胞的自我更新能力。

David Castillo-Azofeifa ,Elena N Fazio ,Roy Nattiv ,Hayley J Good ,Tomas Wald ,Michael A Pest ,Frederic J de Sauvage ,Ophir D Klein ,Samuel Asfaha

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia

细胞长宽比和细胞分裂机制是不同哺乳动物上皮细胞中细胞后代模式的基础

Kara L McKinley, Nico Stuurman, Loic A Royer, Christoph Schartner, David Castillo-Azofeifa, Markus Delling, Ophir D Klein, Ronald D Vale

SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis

Hedgehog 信号调控 SOX2 控制成人舌上皮细胞稳态

David Castillo-Azofeifa, Kerstin Seidel, Lauren Gross, Erin J Golden, Belkis Jacquez, Ophir D Klein, Linda A Barlow

Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance

来自神经和上皮的音猬因子是味蕾维持的关键营养因子

David Castillo-Azofeifa, Justin T Losacco, Ernesto Salcedo, Erin J Golden, Thomas E Finger, Linda A Barlow