日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer-testis antigen PRAME

高亲和力 T 细胞受体 ImmTAC® 双特异性有效重定向 T 细胞以杀死表达癌睾丸抗原 PRAME 的肿瘤细胞

Ana R Ribeiro, Camille Britton-Rivet, Laura Collins, Ricardo J Carreira, Sylvie Moureau, Adel Benlahrech, Sarah Stanhope, Stephen Harper, Nathaniel Liddy, Tara M Mahon, Kristina Petrovic, Mark Fife, David Depoil, Philip Addis, Nicole Bedke, Lucie Bouard, Ronan O'Dwyer, Duncan Gascoyne, Koustubh Rana

Dynamics and spatial organization of Kv1.3 at the immunological synapse of human CD4+ T cells

人类 CD4+ T 细胞免疫突触处 Kv1.3 的动力学和空间组织

Jesusa Capera, Ashwin Jainarayanan, María Navarro-Pérez, Salvatore Valvo, Philippos Demetriou, David Depoil, Irene Estadella, Audun Kvalvaag, James H Felce, Antonio Felipe, Michael L Dustin

A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

免疫突触外缘富含CD2的动态区室增强并整合信号

Philippos Demetriou # ,Enas Abu-Shah # ,Salvatore Valvo ,Sarah McCuaig ,Viveka Mayya ,Audun Kvalvaag ,Thomas Starkey ,Kseniya Korobchevskaya ,Lennard Y W Lee ,Matthias Friedrich ,Elizabeth Mann ,Mikhail A Kutuzov ,Matteo Morotti ,Nina Wietek ,Heather Rada ,Shamsideen Yusuf ,Jehan Afrose ,Anastasios Siokis ,Ahmed Ashour Ahmed ,David Depoil ,Michael L Dustin

Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts

前沿:人类记忆 CD8 T 细胞的突触倾向赋予其相对于幼稚 T 细胞的竞争优势

Viveka Mayya, Edward Judokusumo, Enas Abu-Shah, Willie Neiswanger, Chirag Sachar, David Depoil, Lance C Kam, Michael L Dustin

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

完全控制配体定位揭示了 T 细胞受体触发的空间阈值

Haogang Cai, James Muller, David Depoil, Viveka Mayya, Michael P Sheetz, Michael L Dustin, Shalom J Wind

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

蛋白酪氨酸磷酸酶 PTPN22 调节 LFA-1 依赖性 Th1 反应

Cristina Sanchez-Blanco, Fiona Clarke, Georgina H Cornish, David Depoil, Stephen J Thompson, Xuezhi Dai, David J Rawlings, Michael L Dustin, Rose Zamoyska, Andrew P Cope, Harriet A Purvis

Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse

在缺乏稳定的免疫突触的情况下,T 细胞与 T 细胞受体刺激物的持久相互作用

Viveka Mayya, Edward Judokusumo, Enas Abu Shah, Christopher G Peel, Willie Neiswanger, David Depoil, David A Blair, Chris H Wiggins, Lance C Kam, Michael L Dustin

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

肌动蛋白焦点通过 WASP 通路促进原代 T 淋巴细胞中磷脂酶 C-γ 的激活

Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin

Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells

hRSV 核蛋白的表面表达会损害与 T 细胞的免疫突触形成

Pablo F Céspedes, Susan M Bueno, Bruno A Ramírez, Roberto S Gomez, Sebastián A Riquelme, Christian E Palavecino, Juan Pablo Mackern-Oberti, Jorge E Mora, David Depoil, Catarina Sacristán, Michael Cammer, Alison Creneguy, Tuan H Nguyen, Claudia A Riedel, Michael L Dustin, Alexis M Kalergis

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

荧光恢复测量细胞内钙和肌动蛋白细胞骨架对 TCR 迁移率的影响

Omer Dushek, Sabina Mueller, Sebastien Soubies, David Depoil, Iris Caramalho, Daniel Coombs, Salvatore Valitutti