日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis-infected macrophages

VPS18有助于维持结核分枝杆菌感染巨噬细胞的吞噬体膜完整性

Charul Jani ,Neha Jain ,Amanda K Marsh ,Pooja Uchil ,Triet Doan ,Meggie Hudspith ,Owen T Glover ,Zach R Baskir ,Julie Boucau ,David E Root ,Nicole N van der Wel ,John G Doench ,Amy K Barczak

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

在三阴性乳腺癌中,他汀类药物靶向胆固醇生物合成与AKT抑制剂具有协同作用

Alissandra L Hillis ,Timothy D Martin ,Haley E Manchester ,Jenny Högström ,Na Zhang ,Emmalyn Lecky ,Nina Kozlova ,Jonah Lee ,Nicole S Persky ,David E Root ,Myles Brown ,Karen Cichowski ,Stephen J Elledge ,Taru Muranen ,David A Fruman ,Simon T Barry ,John G Clohessy ,Ralitsa R Madsen ,Alex Toker

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma

全基因组 CRISPR-Cas9 敲除筛选确定 DNMT1 是音猬因子髓母细胞瘤中可用药的依赖性

Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A Segal, Ghazaleh Tabatabai, Daniel J Merk

Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity

由于 HIF2α 活性过高,VHL 基因功能完全丧失会损害神经内分泌癌细胞的适应性

Muhannad Abu-Remaileh, Nicole S Persky, Yenarae Lee, David E Root, William G Kaelin Jr

TYK2 as a novel therapeutic target in Alzheimer's Disease with TDP-43 inclusions

TYK2 作为阿尔茨海默病的新治疗靶点,并加入 TDP-43

Laura E König, Steve Rodriguez, Clemens Hug, Shayda Daneshvari, Alexander Chung, Gary A Bradshaw, Asli Sahin, George Zhou, Robyn J Eisert, Federica Piccioni, Sudeshna Das, Marian Kalocsay, Artem Sokolov, Peter Sorger, David E Root, Mark W Albers

A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas

泛素化级联调控癌细胞的整合应激反应和存活

Lisa D Cervia #,Tsukasa Shibue #,Ashir A Borah,Benjamin Gaeta,Linh He,Lisa Leung,Naomi Li,Sydney M Moyer,Brian H Shim,Nancy Dumont,Alfredo Gonzalez,Nolan R Bick,Mariya Kazachkova,Joshua M Dempster,John Michael Krill-Burger,Federica Piccioni,Namrata D Udeshi,Meagan E Olive,Steven A Carr,David E Root,James M McFarland,Francisca Vazquez #,William C Hahn #

Mapping the landscape of genetic dependencies in chordoma

绘制脊索瘤的遗传依赖性图谱

Tanaz Sharifnia #, Mathias J Wawer #, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M Dempster, Sandrine Muller, Joan Levy, Daniel M Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C Hahn, David E Root, Paul A Clemons, Stuart L Schreiber

EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes

EZH2 与 BRD4-NUT 协同沉默关键肿瘤抑制基因,促进 NUT 癌细胞生长

Yeying Huang #, R Taylor Durall #, Nhi M Luong, Hans J Hertzler, Julianna Huang, Prafulla C Gokhale, Brittaney A Leeper, Nicole S Persky, David E Root, Praju V Anekal, Paula D L M Montero Llopis, Clement N David, Jeffery L Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A Zahnow, Biniam Ad

Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

早期肿瘤发生的类器官模型中扩增异常致癌基因的功能筛选

Ameen A Salahudeen, Jose A Seoane, Kanako Yuki, Amanda T Mah, Amber R Smith, Kevin Kolahi, Sean M De la O, Daniel J Hart, Jie Ding, Zhicheng Ma, Sammy A Barkal, Navika D Shukla, Chuck H Zhang, Michael A Cantrell, Arpit Batish, Tatsuya Usui, David E Root, William C Hahn, Christina Curtis, Calvin J Ku

EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes

EZH2 与 BRD4-NUT 协同作用,通过沉默关键的肿瘤抑制基因来促进 NUT 癌症的生长

Yeying Huang, R Taylor Durall, Nhi M Luong, Hans J Hertzler, Julianna Huang, Prafulla C Gokhale, Brittaney A Leeper, Nicole S Persky, David E Root, Praju V Anekal, Paula D L M Montero Llopis, Clement N David, Jeffery L Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A Zahnow, Biniam Adane,