日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody

获得四级三聚体相互作用是广谱高效HIV-1中和抗体谱系成熟的关键步骤

Qingbo Liu ,Ruth J Parsons ,Kevin Wiehe ,Robert J Edwards ,Kevin O Saunders ,Peng Zhang ,Huiyi Miao ,Kedamawit Tilahun ,Julia Jones ,Yue Chen ,Bhavna Hora ,Wilton B Williams ,David Easterhoff ,Xiao Huang ,Katarzyna Janowska ,Katayoun Mansouri ,Barton F Haynes ,Priyamvada Acharya ,Paolo Lusso

B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates

表达HIV-1中和抗体IgM受体的B细胞通过感知结合结合率来区分抗原亲和力

Md Alamgir Hossain ,Kara Anasti ,Brian Watts ,Kenneth Cronin ,Ronald Derking ,Bettina Groschel ,Advaiti Pai Kane ,R J Edwards ,David Easterhoff ,Jinsong Zhang ,Wes Rountree ,Yaneth Ortiz ,Kevin Saunders ,William R Schief ,Rogier W Sanders ,Laurent Verkoczy ,Michael Reth ,S Munir Alam

Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s

人抗HIV-1 IgG1s的Rheusized变体的结构和Fc效应功能

William D Tolbert ,Dung N Nguyen ,Marina Tuyishime ,Andrew R Crowley ,Yaozong Chen ,Shalini Jha ,Derrick Goodman ,Valerie Bekker ,Sarah V Mudrak ,Anthony L DeVico ,George K Lewis ,James F Theis ,Abraham Pinter ,M Anthony Moody ,David Easterhoff ,Kevin Wiehe ,Justin Pollara ,Kevin O Saunders ,Georgia D Tomaras ,Margaret Ackerman ,Guido Ferrari ,Marzena Pazgier

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

HIV疫苗延迟加强免疫可增强Env可变区2特异性抗体的效应功能

David Easterhoff ,Justin Pollara ,Kan Luo ,Benjamin Janus ,Neelakshi Gohain ,LaTonya D Williams ,Matthew Zirui Tay ,Anthony Monroe ,Kristina Peachman ,Misook Choe ,Susie Min ,Paolo Lusso ,Peng Zhang ,Eden P Go ,Heather Desaire ,Mattia Bonsignori ,Kwan-Ki Hwang ,Charles Beck ,Matina Kakalis ,Robert J O'Connell ,Sandhya Vasan ,Jerome H Kim ,Nelson L Michael ,Jean-Louis Excler ,Merlin L Robb ,Supachai Rerks-Ngarm ,Jaranit Kaewkungwal ,Punnee Pitisuttithum ,Sorachai Nitayaphan ,Faruk Sinangil ,James Tartaglia ,Sanjay Phogat ,Kevin Wiehe ,Kevin O Saunders ,David C Montefiori ,Georgia D Tomaras ,M Anthony Moody ,James Arthos ,Mangala Rao ,M Gordon Joyce ,Gilad Ofek ,Guido Ferrari ,Barton F Haynes

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency

AIDSVAX B/E 加强疫苗可增强 Env 恒定区 1 和 2 抗体依赖性细胞毒性的广度和效力

David Easterhoff, Justin Pollara, Kan Luo, William D Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, Robert J O'Connell, Sandhya Vasan, Jerome Kim, Nelson L Michael, Jean-Louis Excler, Merlin L Robb, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sina

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

通过基因工程改造B细胞成熟过程,靶向选择HIV特异性抗体突变

Kevin O Saunders ,Kevin Wiehe ,Ming Tian ,Priyamvada Acharya ,Todd Bradley ,S Munir Alam ,Eden P Go ,Richard Scearce ,Laura Sutherland ,Rory Henderson ,Allen L Hsu ,Mario J Borgnia ,Haiyan Chen ,Xiaozhi Lu ,Nelson R Wu ,Brian Watts ,Chuancang Jiang ,David Easterhoff ,Hwei-Ling Cheng ,Kelly McGovern ,Peyton Waddicor ,Aimee Chapdelaine-Williams ,Amanda Eaton ,Jinsong Zhang ,Wes Rountree ,Laurent Verkoczy ,Mark Tomai ,Mark G Lewis ,Heather R Desaire ,Robert J Edwards ,Derek W Cain ,Mattia Bonsignori ,David Montefiori ,Frederick W Alt ,Barton F Haynes

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

HIV-1 VRC01 抗体谱系未突变共同祖先的推断揭示了克服关键聚糖障碍的替代途径

Mattia Bonsignori, Eric Scott, Kevin Wiehe, David Easterhoff, S Munir Alam, Kwan-Ki Hwang, Melissa Cooper, Shi-Mao Xia, Ruijun Zhang, David C Montefiori, Rory Henderson, Xiaoyan Nie, Garnett Kelsoe, M Anthony Moody, Xuejun Chen, M Gordon Joyce, Peter D Kwong, Mark Connors, John R Mascola, Andrew T M

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

罕见抗体突变对HIV广谱中和抗体发育的功能意义

Kevin Wiehe ,Todd Bradley ,R Ryan Meyerhoff ,Connor Hart ,Wilton B Williams ,David Easterhoff ,William J Faison ,Thomas B Kepler ,Kevin O Saunders ,S Munir Alam ,Mattia Bonsignori ,Barton F Haynes

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial

在随机双盲 RV305 HIV-1 疫苗试验中增强具有长可变重链第三互补决定区的 HIV 包膜 CD4 结合位点抗体

David Easterhoff, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L Michael, Robert J O'Connell, Jean-Louis Excler, Merlin L Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, P

Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates

简短交流:小分子 CD4 模拟物使非人类灵长类动物中 HIV-1 感染细胞对由多种包膜糖蛋白免疫原引起的抗体的抗体依赖性细胞毒性敏感

Shilei Ding, Myriam M Verly, Amy Princiotto, Bruno Melillo, Anthony M Moody, Todd Bradley, David Easterhoff, Michel Roger, Beatrice H Hahn, Navid Madani, Amos B Smith 3rd, Barton F Haynes, Joseph Sodroski, Andrés Finzi