日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease

小胶质细胞机制驱动阿尔茨海默病免疫患者体内β-淀粉样蛋白的清除

Lynn van Olst ,Brooke Simonton ,Alex J Edwards ,Anne V Forsyth ,Jake Boles ,Pouya Jamshidi ,Thomas Watson ,Nate Shepard ,Talia Krainc ,Benney Mr Argue ,Ziyang Zhang ,Joshua Kuruvilla ,Lily Camp ,Mengwei Li ,Hang Xu ,Jeanette L Norman ,Joshua Cahan ,Robert Vassar ,Jinmiao Chen ,Rudolph J Castellani ,James Ar Nicoll ,Delphine Boche ,David Gate

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

单核细胞可以有效地替代所有脑巨噬细胞,而胎肝单核细胞可以生成真正的SALL1+小胶质细胞。

Jonathan Bastos ,Carleigh O'Brien ,Mónica Vara-Pérez ,Myrthe Mampay ,Lynn van Olst ,Liam Barry-Carroll ,Daliya Kancheva ,Sophia Leduc ,Ayla Line Lievens ,Leen Ali ,Vladislav Vlasov ,Laura Meysman ,Hadis Shakeri ,Ria Roelandt ,Hannah Van Hove ,Karen De Vlaminck ,Isabelle Scheyltjens ,Fazeela Yaqoob ,Sonia I Lombroso ,Maria Breugelmans ,Gilles Faron ,Diego Gomez-Nicola ,David Gate ,F Chris Bennett ,Kiavash Movahedi

Deciphering spatial domains from spatial multi-omics with SpatialGlue

使用 SpatialGlue 解读空间多组学中的空间域

Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng, Lynn van Olst, Shuchen Ye, Chengwei Zhong, Hang Xu, Di Zhang, Immanuel Kwok, Nazihah Husna, Min Jian, Lai Guan Ng, Ao Chen, Nicholas R J Gascoigne, David Gate, Rong Fan, Xun Xu, Jinmiao Chen

Epigenetic dysregulation in Alzheimer's disease peripheral immunity

阿尔茨海默病外周免疫中的表观遗传失调

Abhirami Ramakrishnan ,Natalie Piehl ,Brooke Simonton ,Milan Parikh ,Ziyang Zhang ,Victoria Teregulova ,Lynn van Olst ,David Gate

Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury

抗 CD49d Ab 治疗可改善与年龄相关的炎症反应并减轻创伤性脑损伤后的 CD8+ T 细胞细胞毒性

Zhangying Chen, Kacie P Ford, Mecca B A R Islam, Hanxiao Wan, Hyebin Han, Abhirami Ramakrishnan, Ryan J Brown, Veronica Villanueva, Yidan Wang, Booker T Davis 4th, Craig Weiss, Weiguo Cui, David Gate, Steven J Schwulst

Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging

神经元 ACE1 敲除会破坏海马肾素血管紧张素系统,导致正常衰老过程中的记忆力受损和血管丢失

Sohee Jeon, Miranda A Salvo, Alia O Alia, Jelena Popovic, Mitchell Zagardo, Sidhanth Chandra, Malik Nassan, David Gate, Robert Vassar, Leah K Cuddy0

A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

人类脑血管图谱揭示了阿尔茨海默病风险的多种调节因素

Andrew C Yang,Ryan T Vest #,Fabian Kern #,Davis P Lee,Maayan Agam,Christina A Maat,Patricia M Losada,Michelle B Chen,Nicholas Schaum,Nathalie Khoury,Angus Toland,Kruti Calcuttawala,Heather Shin,Róbert Pálovics,Andrew Shin,Elizabeth Y Wang,Jian Luo,David Gate,Walter J Schulz-Schaeffer,Pauline Chu,Julie A Siegenthaler,M Windy McNerney,Andreas Keller,Tony Wyss-Coray

Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer's Disease Transgenic Mice as Tissue-Resident Memory T Cells

转录组分析鉴定出老年和阿尔茨海默病转基因小鼠脑中的 CD8+ T 细胞为组织驻留记忆 T 细胞

Barbara Altendorfer, Michael Stefan Unger, Rodolphe Poupardin, Anna Hoog, Daniela Asslaber, Iris Karina Gratz, Heike Mrowetz, Ariane Benedetti, Diana Marisa Bessa de Sousa, Richard Greil, Alexander Egle, David Gate, Tony Wyss-Coray, Ludwig Aigner2

Dysregulation of brain and choroid plexus cell types in severe COVID-19

重症新冠肺炎患者大脑和脉络丛细胞类型失调

Andrew C Yang #, Fabian Kern #, Patricia M Losada, Maayan R Agam, Christina A Maat, Georges P Schmartz, Tobias Fehlmann, Julian A Stein, Nicholas Schaum, Davis P Lee, Kruti Calcuttawala, Ryan T Vest, Daniela Berdnik, Nannan Lu, Oliver Hahn, David Gate, M Windy McNerney, Divya Channappa, Inma Cobos, 

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

CD22-IGF2R 相互作用是治疗 C 型尼曼-匹克小胶质细胞溶酶体功能障碍的靶点

John V Pluvinage, Jerry Sun, Christel Claes, Ryan A Flynn, Michael S Haney, Tal Iram, Xiangling Meng, Rachel Lindemann, Nicholas M Riley, Emma Danhash, Jean Paul Chadarevian, Emma Tapp, David Gate, Sravani Kondapavulur, Inma Cobos, Sundari Chetty, Anca M Pașca, Sergiu P Pașca, Elizabeth Berry-Kravis