日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors

灵长类动物保守的碳酸酐酶IV和小鼠限制的LY6C1使工程病毒载体能够穿过血脑屏障

Timothy F Shay, Erin E Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Brown, Anaya Crosby, Jost Vielmetter, Máté Borsos, Damien A Wolfe, Annie W Lam, Viviana Gradinaru

Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid

通过定向进化 AAV 衣壳上尚未充分探索的位点,实现静脉注射后靶向肺上皮

David Goertsen, Nick Goeden, Nicholas C Flytzanis, Viviana Gradinaru