日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Toxigenic Clostridium perfringens Isolated from At-Risk Paediatric Inflammatory Bowel Disease Patients

从儿童炎症性肠病高危人群中分离出的产毒产气荚膜梭菌

James Kuo, Jasmina Uzunovic, Amanda Jacobson, Michelle Dourado, Sarah Gierke, Manohary Rajendram, Daniela Keilberg, Jordan Mar, Emily Stekol, Joanna Curry, Sofia Verstraete, Jessica Lund, Yuxin Liang, Fiona B Tamburini, Natalie S Omattage, Matthieu Masureel, Steven T Rutherford, David H Hackos, Man-

Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons

特定情境的压力导致皮质神经元中 SARM1 的区间化激活和局部退化

Flora I Hinz, Carmela Louise M Villegas, Jasmine T Roberts, Heming Yao, Shreya Gaddam, Anton Delwig, Samantha A Green, Craig Fredrickson, Max Adrian, Raymond R Asuncion, Tommy K Cheung, Margaret Hayne, David H Hackos, Christopher M Rose, David Richmond, Casper C Hoogenraad

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function

跨物种背根神经节转录组图谱揭示了物种特异性的感觉功能程序

Min Jung #, Michelle Dourado #, James Maksymetz, Amanda Jacobson, Benjamin I Laufer, Miriam Baca, Oded Foreman, David H Hackos, Lorena Riol-Blanco, Joshua S Kaminker

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma

CRISPR 产生的 TRPA1 基因敲除大鼠在疼痛、瘙痒和哮喘模型中的行为表征

Rebecca M Reese #, Michelle Dourado #, Keith Anderson, Søren Warming, Kimberly L Stark, Alessia Balestrini, Eric Suto, Wyne Lee, Lorena Riol-Blanco, Shannon D Shields, David H Hackos

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors

成年后缺失 Nav1.7 或使用选择性抑制剂阻断 Nav1.7 会导致对疼痛不敏感

Shannon D Shields, Lunbin Deng, Rebecca M Reese, Michelle Dourado, Janet Tao, Oded Foreman, Jae H Chang, David H Hackos

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

机制特异性检测设计有助于发现 Nav1.7 选择性抑制剂

Tania Chernov-Rogan, Tianbo Li, Gang Lu, Henry Verschoof, Kuldip Khakh, Steven W Jones, Maureen H Beresini, Chang Liu, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Daniel Sutherlin, Charles J Cohen, Jun Chen

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

钾通道 Kv1.3 和 KCa3.1 协同和补偿性调节抗原特异性记忆 T 细胞功能

Eugene Y Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H Hackos, Susmith Mukund, Christopher M Koth, Jane L Grogan

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

一种通过跨膜结构域起作用的新型 NMDA 受体正变构调节剂

Tzu-Ming Wang, Brandon M Brown, Lunbin Deng, Benjamin D Sellers, Patrick J Lupardus, Heidi J A Wallweber, Amy Gustafson, Evera Wong, Matthew Volgraf, Jacob B Schwarz, David H Hackos, Jesse E Hanson

Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons

组蛋白去乙酰化酶 2 细胞自主抑制 CA1 锥体神经元兴奋性突触功能并增强抑制性突触功能

Jesse E Hanson, Lunbin Deng, David H Hackos, Shih-Ching Lo, Benjamin E Lauffer, Pascal Steiner, Qiang Zhou

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

AF-353,一种新型、有效且口服生物可利用的 P2X3/P2X2/3 受体拮抗剂

Joel R Gever, Rothschild Soto, Robert A Henningsen, Renee S Martin, David H Hackos, Sandip Panicker, Werner Rubas, Ian B Oglesby, Michael P Dillon, Marcos E Milla, Geoffrey Burnstock, Anthony P D W Ford