日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Local Conditions and Environmental Gradients Shape the Abundance and Size Structure of a Non-Native Intertidal Species in Atlantic North America

局部条件和环境梯度塑造了大西洋北美潮间带非本土物种的丰度和体型结构

Garlaschè, Giuseppe; Broitman, Bernardo R; Riley, Cyrena; Drolet, David; Howland, Kimberly L; McKindsey, Christopher W; Calosi, Piero

Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreas

成年小鼠整体亨廷顿蛋白敲除导致致命的神经退行性病变,但胰腺不会受到影响

Robert M Bragg, Ella W Mathews, Andrea Grindeland, Jeffrey P Cantle, David Howland, Tom Vogt, Jeffrey B Carroll

Mutations causing Lopes-Maciel-Rodan syndrome are huntingtin hypomorphs

导致洛佩斯-马西尔-罗丹综合征的突变是亨廷顿基因次等位基因

Roy Jung, Yejin Lee, Douglas Barker, Kevin Correia, Baehyun Shin, Jacob Loupe, Ryan L Collins, Diane Lucente, Jayla Ruliera, Tammy Gillis, Jayalakshmi S Mysore, Lance Rodan, Jonathan Picker, Jong-Min Lee, David Howland, Ramee Lee, Seung Kwak, Marcy E MacDonald, James F Gusella, Ihn Sik Seong

Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease

人工 miRNA 可降低亨廷顿氏病转基因绵羊模型中纹状体中的人类突变型亨廷顿蛋白

Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guan

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

抑制 RGSz1 功能可通过涉及 Wnt/β-catenin 通路的机制优化阿片类镇痛药的作用

Sevasti Gaspari, Immanuel Purushothaman, Valeria Cogliani, Farhana Sakloth, Rachael L Neve, David Howland, Robert H Ring, Elliott M Ross, Li Shen, Venetia Zachariou

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients

亨廷顿病患者体内致病性外显子1 HTT蛋白是由不完全剪接产生的。

Andreas Neueder ,Christian Landles ,Rhia Ghosh ,David Howland ,Richard H Myers ,Richard L M Faull ,Sarah J Tabrizi ,Gillian P Bates

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice

整合基因组学和蛋白质组学定义小鼠亨廷顿 CAG 长度依赖网络

Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao, Sandeep Deverasetty, Andreas Tebbe, Christoph Schaab, Daniel J Lavery, David Howland, Seung Kwak, Juan Botas, Jeffrey S Aaronson, Jim Rosinski

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

HTT 的异常剪接产生亨廷顿病的致病外显子 1 蛋白

Kirupa Sathasivam, Andreas Neueder, Theresa A Gipson, Christian Landles, Agnesska C Benjamin, Marie K Bondulich, Donna L Smith, Richard L M Faull, Raymund A C Roos, David Howland, Peter J Detloff, David E Housman, Gillian P Bates

Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment

BACHD 小鼠中的 Caspase-6 活性调节突变亨廷顿蛋白的稳态水平,但对于 586 个氨基酸蛋白水解片段的产生并非必需

Juliette Gafni, Theodora Papanikolaou, Francesco Degiacomo, Jennifer Holcomb, Sylvia Chen, Liliana Menalled, Andrea Kudwa, Jon Fitzpatrick, Sam Miller, Sylvie Ramboz, Pasi I Tuunanen, Kimmo K Lehtimäki, X William Yang, Larry Park, Seung Kwak, David Howland, Hyunsun Park, Lisa M Ellerby

Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease

Caspase-6 不参与亨廷顿氏病 HdhQ150 敲入小鼠模型中突变亨廷顿蛋白的蛋白水解

Christian Landles, Andreas Weiss, Sophie Franklin, David Howland, Gill Bates