日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function

TET2调控耗竭CD8+ T细胞分化的早期和晚期转变,并限制CAR T细胞的功能。

Alexander J Dimitri,Amy E Baxter,Gregory M Chen,Caitlin R Hopkins,Geoffrey T Rouin,Hua Huang,Weimin Kong,Christopher H Holliday,Volker Wiebking,Robert Bartoszek,Sydney Drury,Katherine Dalton,Owen M Koucky,Zeyu Chen,Josephine R Giles,Alexander T Dils,In-Young Jung,Roddy O'Connor,Sierra Collins,John K Everett,Kevin Amses,Scott Sherrill-Mix,Aditi Chandra,Naomi Goldman,Golnaz Vahedi,Julie K Jadlowsky,Regina M Young,Jan Joseph Melenhorst,Shannon L Maude,Bruce L Levine,Noelle V Frey,Shelley L Berger,Stephan A Grupp,David L Porter,Friederike Herbst,Matthew H Porteus,Shannon A Carty,Frederic D Bushman,Evan W Weber,E John Wherry,Martha S Jordan,Joseph A Fraietta

Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction

I型干扰素通过EGR2转录调节因子发出信号,增强CAR T细胞固有功能障碍

In-Young Jung ,Robert L Bartoszek ,Andrew J Rech ,Sierra M Collins ,Soon-Keat Ooi ,Erik F Williams ,Caitlin R Hopkins ,Vivek Narayan ,Naomi B Haas ,Noelle V Frey ,Elizabeth O Hexner ,Donald L Siegel ,Gabriela Plesa ,David L Porter ,Adrian Cantu ,John K Everett ,Sonia Guedan ,Shelley L Berger ,Frederic D Bushman ,Friederike Herbst ,Joseph A Fraietta

Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells

抑制性共受体CTLA-4的缺失可增强并激活嵌合抗原受体T细胞。

Sangya Agarwal ,M Angela Aznar ,Andrew J Rech ,Charly R Good ,Shunichiro Kuramitsu ,Tong Da ,Mercy Gohil ,Linhui Chen ,Seok-Jae Albert Hong ,Pranali Ravikumar ,Austin K Rennels ,January Salas-Mckee ,Weimin Kong ,Marco Ruella ,Megan M Davis ,Gabriela Plesa ,Joseph A Fraietta ,David L Porter ,Regina M Young ,Carl H June

The future of patient-derived xenografts in prostate cancer research

患者来源异种移植在前列腺癌研究中的未来

Lawrence, Mitchell G; Taylor, Renea A; Cuffe, Georgia B; Ang, Lisa S; Clark, Ashlee K; Goode, David L; Porter, Laura H; Le Magnen, Clémentine; Navone, Nora M; Schalken, Jack A; Wang, Yuzhuo; van Weerden, Wytske M; Corey, Eva; Isaacs, John T; Nelson, Peter S; Risbridger, Gail P

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

CD4+ CAR-T 细胞可使白血病缓解长达十年

J Joseph Melenhorst #, Gregory M Chen #, Meng Wang #, David L Porter #, Changya Chen, McKensie A Collins, Peng Gao, Shovik Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L Nobles, Sayantan Maji, Noelle V Frey, Saar I Gill, Alison W Loren, Lifeng Tian, Ir

A framework for role allocation in education, research and leadership services in Canadian academic divisions of general surgery: a modified Delphi consensus

加拿大普通外科各学术部门教育、研究和领导服务角色分配框架:一种改进的德尔菲共识

Reid, Morgann; Lee, Alex; Leslie, Ken; Feldman, Liane S; Hameed, S Morad; Kirkpatrick, Roy; Lovrics, Peter J; MacDonald, P Hugh; Pace, David; Shaw, John M; Swallow, Carol J; Pagliarello, Giuseppe; Bigam, David L; Porter, Geoff; Mathieson, Alex; McFadden, Nathalie; Lapointe, Réal; MacLean, Tony; Kuziemsky, Craig; Balaa, Fady

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

经 CCR5 编辑的 CD4+ T 细胞可增强 HIV 特异性免疫力,从而实现 HIV 病毒反弹后复制的控制。

Pablo Tebas ,Julie K Jadlowsky ,Pamela A Shaw ,Lifeng Tian ,Erin Esparza ,Andrea L Brennan ,Sukyung Kim ,Soe Yu Naing ,Max W Richardson ,Ashley N Vogel ,Colby R Maldini ,Hong Kong ,Xiaojun Liu ,Simon F Lacey ,Anya M Bauer ,Felicity Mampe ,Lee P Richman ,Gary Lee ,Dale Ando ,Bruce L Levine ,David L Porter ,Yangbing Zhao ,Don L Siegel ,Katharine J Bar ,Carl H June ,James L Riley

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy

慢性淋巴细胞白血病细胞损害 CD8+ T 细胞的线粒体适应性并阻碍 CAR-T 细胞功效

Jaco A C van Bruggen, Anne W J Martens, Joseph A Fraietta, Tom Hofland, Sanne H Tonino, Eric Eldering, Mark-David Levin, Peter J Siska, Sanne Endstra, Jeffrey C Rathmell, Carl H June, David L Porter, J Joseph Melenhorst, Arnon P Kater, Gerritje J W van der Windt

Extended CCR5 Blockade for Graft-versus-Host Disease Prophylaxis Improves Outcomes of Reduced-Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial

延长 CCR5 阻断以预防移植物抗宿主病可改善低强度无关供体造血细胞移植的结果:一项 II 期临床试验

Ran Reshef, Alex Ganetsky, Edward P Acosta, Robin Blauser, Lisa Crisalli, Jessica McGraw, Noelle V Frey, Elizabeth O Hexner, James A Hoxie, Alison W Loren, Selina M Luger, James Mangan, Edward A Stadtmauer, Rosemarie Mick, Robert H Vonderheide, David L Porter

Pharmacodynamic Monitoring Predicts Outcomes of CCR5 Blockade as Graft-versus-Host Disease Prophylaxis

药效学监测可预测 CCR5 阻断作为移植物抗宿主病预防的结果

Austin P Huffman, Lee P Richman, Lisa Crisalli, Alex Ganetsky, David L Porter, Robert H Vonderheide, Ran Reshef