日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer

预测 sacituzumab govitecan 对 Trop-2 表达三阴性乳腺癌疗效的生物标志物

Thomas M Cardillo, Diane L Rossi, Maria B Zalath, Donglin Liu, Roberto Arrojo, Robert M Sharkey, Chien-Hsing Chang, David M Goldenberg

α- Versus β-Emitting Radionuclides for Pretargeted Radioimmunotherapy of Carcinoembryonic Antigen-Expressing Human Colon Cancer Xenografts

α 和 β 发射放射性核素对表达癌胚抗原的人类结肠癌异种移植瘤的预定位放射免疫治疗

Sandra Heskamp, Reinier Hernandez, Janneke D M Molkenboer-Kuenen, Markus Essler, Frank Bruchertseifer, Alfred Morgenstern, Erik J Steenbergen, Weibo Cai, Christof Seidl, William J McBride, David M Goldenberg, Otto C Boerman

Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers

将 ABCG2 抑制剂与 SN-38 的抗 Trop-2 抗体结合物 IMMU-132 相结合,可克服乳腺癌和胃癌对 SN-38 的耐药性

Chien-Hsing Chang, Yang Wang, Maria Zalath, Donglin Liu, Thomas M Cardillo, David M Goldenberg

First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors

新型抗Trop-2抗体-SN-38结合物Sacituzumab Govitecan首次人体试验,用于治疗多种转移性实体肿瘤

Alexander N Starodub, Allyson J Ocean, Manish A Shah, Michael J Guarino, Vincent J Picozzi Jr, Linda T Vahdat, Sajeve S Thomas, Serengulam V Govindan, Pius P Maliakal, William A Wegener, Steven A Hamburger, Robert M Sharkey, David M Goldenberg

Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)

Trop-2 是使用抗体-药物偶联物 (ADC) sacituzumab govitecan (IMMU-132) 治疗实体癌的新靶点

David M Goldenberg, Thomas M Cardillo, Serengulam V Govindan, Edmund A Rossi, Robert M Sharkey

Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: a promising biomarker and therapeutic target for pancreatic cancer

鉴定 MUC5AC 上的 PAM4(克利瓦妥珠单抗)反应表位:一种有前途的胰腺癌生物标志物和治疗靶点

Donglin Liu, Chien-Hsing Chang, David V Gold, David M Goldenberg

Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancer

靶向 Trop-2 的四肽豹糖酶对三阴性乳腺癌具有强效抗肿瘤活性

Donglin Liu, Thomas M Cardillo, Yang Wang, Edmund A Rossi, David M Goldenberg, Chien-Hsing Chang

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus

具有增强吞噬作用的抗 CD22/CD20 双特异性抗体用于治疗狼疮

Edmund A Rossi, Chien-Hsing Chang, David M Goldenberg

Milatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies

米拉珠单抗结合脂质体作为地塞米松靶向载体用于 CD74+ B 细胞恶性肿瘤的治疗输送

Yicheng Mao, Georgia Triantafillou, Erin Hertlein, William Towns, Matthew Stefanovski, Xiaokui Mo, David Jarjoura, Mitch Phelps, Guido Marcucci, Ly James Lee, David M Goldenberg, Robert J Lee, John C Byrd, Natarajan Muthusamy

Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro

同时靶向 IGF-1R 和 mTOR 可协同抑制体外肾细胞癌的生长

Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg, Chien-Hsing Chang