日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life after omega-3 PUFA supplementation and aerobic exercise training in individuals with rheumatoid arthritis: a randomized 16-week, placebo-controlled interventional trial

ω-3多不饱和脂肪酸补充剂和有氧运动训练对类风湿性关节炎患者炎症、心血管代谢健康、疾病进展和生活质量的影响:一项随机、16周、安慰剂对照干预试验

Jannas-Vela, Sebastián; Candia, Alejandro A; Peñailillo, Luis; Barrios-Troncoso, Paola; Zapata-Urzúa, Jeremy; Rey-Puente, Joanny; Aukema, Harold M; Mutch, David M; Valenzuela, Rodrigo; Valladares-Ide, Denisse

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

神经元表面 P 抗原 (NSPA) 通过酪氨酸磷酸酶 PTPMEG 泛素化调节突触后 NMDAR 稳定性

Sofía Espinoza, Sebastián B Arredondo, Francisca Barake, Francisco Carvajal, Fernanda G Guerrero, Fabian Segovia-Miranda, David M Valenzuela, Ursula Wyneken, Alejandro Rojas-Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela-Nallar, Alfonso González

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

半乳糖凝集素-8 作为实验性自身免疫性脑脊髓炎的免疫抑制剂和多发性硬化症中人类早期预后抗体的靶点

Evelyn Pardo, Claudia Cárcamo, Reinaldo Uribe-San Martín, Ethel Ciampi, Fabián Segovia-Miranda, Cristobal Curkovic-Peña, Fabián Montecino, Christopher Holmes, Juan Enrique Tichauer, Eric Acuña, Francisco Osorio-Barrios, Marjorie Castro, Priscilla Cortes, Claudia Oyanadel, David M Valenzuela, Rodrigo

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury

携带突变 Inf2 的小鼠在鱼精蛋白诱发的肾损伤中表现出足细胞和裂孔膈完整性受损

Balajikarthick Subramanian, Hua Sun, Paul Yan, Victoria T Charoonratana, Henry N Higgs, Fang Wang, Ka-Man V Lai, David M Valenzuela, Elizabeth J Brown, Johannes S Schlöndorff, Martin R Pollak

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2

ANGPTL4-αvβ3 相互作用通过调节血管内皮生长因子受体 2 下游的 Src 信号传导来抵消缺氧引起的血管通透性

Elisa Gomez Perdiguero, Athanasia Liabotis-Fontugne, Mélanie Durand, Clément Faye, Sylvie Ricard-Blum, Manuel Simonutti, Sébastien Augustin, Bryan M Robb, Michel Paques, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Gavin Thurston, Ariane Galaup, Catherine Monnot, Stéphane Germain

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

使用人类单克隆抗体阻断 ANGPTL3 可降低血脂异常小鼠和猴子的血脂

Viktoria Gusarova, Corey A Alexa, Yan Wang, Ashique Rafique, Jee Hae Kim, David Buckler, Ivory J Mintah, Lisa M Shihanian, Jonathan C Cohen, Helen H Hobbs, Yurong Xin, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Jesper Gromada

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice

GPR17 基因破坏不会改变小鼠的食物摄入量或葡萄糖稳态

Jason Mastaitis, Soo Min, Ralf Elvert, Aimo Kannt, Yurong Xin, Francisca Ochoa, Nicholas W Gale, David M Valenzuela, Andrew J Murphy, George D Yancopoulos, Jesper Gromada

Tim-1 regulates Th2 responses in an airway hypersensitivity model

Tim-1 在气道高敏性模型中调节 Th2 反应

Miranda L Curtiss, Jacob V Gorman, Thomas R Businga, Geri Traver, Melody Singh, David K Meyerholz, Joel N Kline, Andrew J Murphy, David M Valenzuela, John D Colgan, Paul B Rothman, Suzanne L Cassel

Postsymptomatic restoration of SMN rescues the disease phenotype in a mouse model of severe spinal muscular atrophy

在严重脊髓性肌萎缩症小鼠模型中,SMN 的症状后恢复可挽救疾病表型

Cathleen M Lutz, Shingo Kariya, Sunita Patruni, Melissa A Osborne, Don Liu, Christopher E Henderson, Darrick K Li, Livio Pellizzoni, José Rojas, David M Valenzuela, Andrew J Murphy, Margaret L Winberg, Umrao R Monani

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

生长素释放肽 O-酰基转移酶 (GOAT) 对生长激素介导的热量限制小鼠的生存至关重要

Tong-Jin Zhao, Guosheng Liang, Robert Lin Li, Xuefen Xie, Mark W Sleeman, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Joseph L Goldstein, Michael S Brown