日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Longitudinal Characterization of Transcriptomic, Functional, and Morphological Features in Human iPSC-Derived Neurons and Their Application to Investigate Translational Progranulin Disease Biology

人类 iPSC 衍生神经元的转录组学、功能和形态学特征的纵向表征及其在研究转化前颗粒蛋白疾病生物学中的应用

Gaëlle Robin, J Corey Evans, David N Hauser, Paul Wren, Andreas Zembrzycki

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

蛋白质组学分析揭示 LRRK2 基因敲除小鼠的蛋白质合成和降解途径发生协调改变

Laura Pellegrini, David N Hauser, Yan Li, Adamantios Mamais, Alexandra Beilina, Ravindran Kumaran, Andrea Wetzel, Jonathon Nixon-Abell, George Heaton, Iakov Rudenko, Mor Alkaslasi, Natalie Ivanina, Heather L Melrose, Mark R Cookson, Kirsten Harvey

Hexokinases link DJ-1 to the PINK1/parkin pathway

己糖激酶将 DJ-1 与 PINK1/parkin 通路连接起来

David N Hauser, Adamantios Mamais, Melissa M Conti, Christopher T Primiani, Ravindran Kumaran, Allissa A Dillman, Rebekah G Langston, Alexandra Beilina, Joseph H Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R Cookson

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice

Polg 突变表型不会导致 DJ-1 缺陷小鼠发生多巴胺能神经变性

David N Hauser, Christopher T Primiani, Rebekah G Langston, Ravindran Kumaran, Mark R Cookson

Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers

使用半胱氨酸反应性交联剂探测人类 DJ-1 的构象灵活性,证明 Glu18 突变是二聚体

Janani Prahlad, David N Hauser, Nicole M Milkovic, Mark R Cookson, Mark A Wilson

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

亚砷酸盐应激下调富含亮氨酸重复激酶 2 (LRRK2) 的磷酸化和 14-3-3 结合,促进自我结合和细胞重新分布

Adamantios Mamais, Ruth Chia, Alexandra Beilina, David N Hauser, Christine Hall, Patrick A Lewis, Mark R Cookson, Rina Bandopadhyay

Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain

Polg 突变小鼠脑内呼吸链蛋白翻译后减少

David N Hauser, Allissa A Dillman, Jinhui Ding, Yan Li, Mark R Cookson

Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

多巴胺醌修饰并降低线粒体硒蛋白谷胱甘肽过氧化物酶 4 的丰度

David N Hauser, April A Dukes, Amanda D Mortimer, Teresa G Hastings

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

p62/SQSTM1 是 Parkin 诱导的线粒体聚集所必需的,但不是线粒体自噬所必需的;VDAC1 对这两者都是可有可无的

Derek Narendra, Lesley A Kane, David N Hauser, Ian M Fearnley, Richard J Youle