日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

鼻内亚单位疫苗可在小鼠模型中诱导针对呼吸道病毒的保护性全身和黏膜抗体免疫。

Aina Karen Anthi ,Anette Kolderup # ,Eline Benno Vaage # ,Malin Bern # ,Sopisa Benjakul ,Elias Tjärnhage ,Fulgencio Ruso-Julve ,Kjell-Rune Jensen ,Heidrun Elisabeth Lode ,Marina Vaysburd ,Jeannette Nilsen ,Marie Leangen Herigstad ,Siri Aastedatter Sakya ,Lisa Tietze ,Diego Pilati ,Mari Nyquist-Andersen ,Mirjam Dürkoop ,Torleif Tollefsrud Gjølberg ,Linghang Peng ,Stian Foss ,Morten C Moe ,Benjamin E Low ,Michael V Wiles ,David Nemazee ,Frode L Jahnsen ,John Torgils Vaage ,Kenneth A Howard ,Inger Sandlie ,Leo C James ,Gunnveig Grødeland ,Fridtjof Lund-Johansen ,Jan Terje Andersen

Loss of Bcl6 promotes antitumor immunity by activating glycolysis to rescue CD8 T-cell function

Bcl6 的缺失通过激活糖酵解来恢复 CD8 T 细胞功能,从而促进抗肿瘤免疫。

Fangkun Luan,Yunqiao Li,Jia Ning,Jenny Tuyet Tran,Tanya R Blane,Raag Bhargava,Zhe Huang,Changchun Xiao,David Nemazee

Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis

分泌白细胞介素-2的辅助性T细胞通过对B细胞mTOR-AKT-Blimp-1轴的内在调控促进滤泡外B细胞成熟。

Caterina E Faliti ,Maria Mesina ,Jinyong Choi ,Simon Bélanger ,Monique A Marshall ,Christopher M Tipton ,Sakeenah Hicks ,Prashanti Chappa ,Maria A Cardenas ,Mohamed Abdel-Hakeem ,Theresa C Thinnes ,Christopher Cottrell ,Christopher D Scharer ,William R Schief ,David Nemazee ,Matthew C Woodruff ,John M Lindner ,Ignacio Sanz ,Shane Crotty

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

广谱中和性抗S2抗体可预防所有三种引起致命疾病的人类β冠状病毒。

Panpan Zhou ,Ge Song ,Hejun Liu ,Meng Yuan ,Wan-Ting He ,Nathan Beutler ,Xueyong Zhu ,Longping V Tse ,David R Martinez ,Alexandra Schäfer ,Fabio Anzanello ,Peter Yong ,Linghang Peng ,Katharina Dueker ,Rami Musharrafieh ,Sean Callaghan ,Tazio Capozzola ,Oliver Limbo ,Mara Parren ,Elijah Garcia ,Stephen A Rawlings ,Davey M Smith ,David Nemazee ,Joseph G Jardine ,Yana Safonova ,Bryan Briney ,Thomas F Rogers ,Ian A Wilson ,Ralph S Baric ,Lisa E Gralinski ,Dennis R Burton ,Raiees Andrabi

Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses

罕见的、趋同的抗体靶向茎螺旋结构,可广泛中和多种β冠状病毒

Cherrelle Dacon ,Linghang Peng ,Ting-Hui Lin ,Courtney Tucker ,Chang-Chun D Lee ,Yu Cong ,Lingshu Wang ,Lauren Purser ,Andrew J R Cooper ,Jazmean K Williams ,Chul-Woo Pyo ,Meng Yuan ,Ivan Kosik ,Zhe Hu ,Ming Zhao ,Divya Mohan ,Mary Peterson ,Jeff Skinner ,Saurabh Dixit ,Erin Kollins ,Louis Huzella ,Donna Perry ,Russell Byrum ,Sanae Lembirik ,Michael Murphy ,Yi Zhang ,Eun Sung Yang ,Man Chen ,Kwanyee Leung ,Rona S Weinberg ,Amarendra Pegu ,Daniel E Geraghty ,Edgar Davidson ,Benjamin J Doranz ,Iyadh Douagi ,Susan Moir ,Jonathan W Yewdell ,Connie Schmaljohn ,Peter D Crompton ,John R Mascola ,Michael R Holbrook ,David Nemazee ,Ian A Wilson ,Joshua Tan

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

分子佐剂 C3d 与不依赖切割的天然 HIV-1 Env 三聚体的融合可改善所引发的抗体反应

Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D Doyle, Christopher A Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B Ward, Richard T Wyatt

Efficient isolation of rare B cells using next-generation antigen barcoding

使用下一代抗原条形码技术有效分离稀有 B 细胞

Jonathan Hurtado, Claudia Flynn, Jeong Hyun Lee, Eugenia C Salcedo, Christopher A Cottrell, Patrick D Skog, Dennis R Burton, David Nemazee, William R Schief, Elise Landais, Devin Sok, Bryan Briney

Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

通过定向进化扩大 SARS-CoV-1 中和抗体,以实现强效 SARS-CoV-2 中和

Fangzhu Zhao, Meng Yuan, Celina Keating, Namir Shaabani, Oliver Limbo, Collin Joyce, Jordan Woehl, Shawn Barman, Alison Burns, Quoc Tran, Xueyong Zhu, Michael Ricciardi, Linghang Peng, Jessica Smith, Deli Huang, Bryan Briney, Devin Sok, David Nemazee, John R Teijaro, Ian A Wilson, Dennis R Burton, J

In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

体内工程改造的B细胞在小鼠体内分泌高滴度的广谱中和抗HIV抗体。

Alessio D Nahmad,Cicera R Lazzarotto,Natalie Zelikson,Talia Kustin,Mary Tenuta,Deli Huang,Inbal Reuveni,Daniel Nataf,Yuval Raviv,Miriam Horovitz-Fried,Iris Dotan,Yaron Carmi,Rina Rosin-Arbesfeld,David Nemazee,James E Voss,Adi Stern,Shengdar Q Tsai,Adi Barzel

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

在恒河猴体内很容易诱导产生针对SARS相关病毒的广谱中和抗体。

Wan-Ting He ,Meng Yuan ,Sean Callaghan ,Rami Musharrafieh ,Ge Song ,Murillo Silva ,Nathan Beutler ,Wen-Hsin Lee ,Peter Yong ,Jonathan L Torres ,Mariane Melo ,Panpan Zhou ,Fangzhu Zhao ,Xueyong Zhu ,Linghang Peng ,Deli Huang ,Fabio Anzanello ,James Ricketts ,Mara Parren ,Elijah Garcia ,Melissa Ferguson ,William Rinaldi ,Stephen A Rawlings ,David Nemazee ,Davey M Smith ,Bryan Briney ,Yana Safonova ,Thomas F Rogers ,Jennifer M Dan ,Zeli Zhang ,Daniela Weiskopf ,Alessandro Sette ,Shane Crotty ,Darrell J Irvine ,Andrew B Ward ,Ian A Wilson ,Dennis R Burton ,Raiees Andrabi