日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A druggable conformational switch in the c-MYC transactivation domain

c-MYC转录激活结构域中可成药的构象转换

Dilraj Lama # ,Thibault Vosselman # ,Cagla Sahin ,Judit Liaño-Pons ,Carmine P Cerrato ,Lennart Nilsson ,Kaare Teilum ,David P Lane ,Michael Landreh ,Marie Arsenian Henriksson

Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

具有体内活性的肽链设计规则及其在Mdm2/X拮抗剂中的应用

Arun Chandramohan ,Hubert Josien ,Tsz Ying Yuen ,Ruchia Duggal ,Diana Spiegelberg ,Lin Yan ,Yu-Chi Angela Juang ,Lan Ge ,Pietro G Aronica ,Hung Yi Kristal Kaan ,Yee Hwee Lim ,Andrea Peier ,Brad Sherborne ,Jerome Hochman ,Songnian Lin ,Kaustav Biswas ,Marika Nestor ,Chandra S Verma ,David P Lane ,Tomi K Sawyer ,Robert Garbaccio ,Brian Henry ,Srinivasaraghavan Kannan ,Christopher J Brown ,Charles W Johannes ,Anthony W Partridge

p53 stabilisation potentiates [177Lu]Lu-DOTATATE treatment in neuroblastoma xenografts

p53 稳定性增强了神经母细胞瘤异种移植中的 [177Lu]Lu-DOTATATE 治疗

Hanna Berglund #, Sara Lundsten Salomonsson #, Tabassom Mohajershojai, Fernando Jose Ferrer Gago, David P Lane, Marika Nestor

MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors

Sulanemadlin 对 MDM2/MDMX 的抑制作用与抗程序性死亡受体 1 免疫疗法在野生型 p53 肿瘤中具有协同作用

Katrine Ingelshed ,Marit M Melssen ,Pavitra Kannan ,Arun Chandramohan ,Anthony W Partridge ,Long Jiang ,Fredrik Wermeling ,David P Lane ,Marika Nestor ,Diana Spiegelberg

A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays

高通量微流体机械穿孔平台,可在基于细胞的分析中实现环肽的细胞内递送

Stephen H Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr-Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S Verma, Christopher J Brown, Charles W Johannes, David P Lane, Arun Chandramohan, Anthony W Partridge, Lee R Roberts, Hubert Josien, Alex G Therien, Eri

MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

MDM2 抑制剂 nutlin-3a 和 navtemadelin 在缺氧培养的人类和小鼠癌细胞中保持功效

Ada Lerma Clavero, Paula Lafqvist Boqvist, Katrine Ingelshed, Cecilia Bosdotter, Saikiran Sedimbi, Long Jiang, Fredrik Wermeling, Borivoj Vojtesek, David P Lane, Pavitra Kannan

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex

设计一个自主的 VH 结构域来调节细胞内通路并检测 eIF4F 复合物

Yuri Frosi #, Yen-Chu Lin #, Jiang Shimin #, Siti Radhiah Ramlan, Kelly Hew, Alf Henrik Engman, Anil Pillai, Kit Yeung, Yue Xiang Cheng, Tobias Cornvik, Par Nordlund, Megan Goh, Dilraj Lama, Zachary P Gates, Chandra S Verma, Dawn Thean, David P Lane, Ignacio Asial, Christopher J Brown

CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity

CETSA 相互作用蛋白质组学将特定的 RNA 修饰途径定义为氟尿嘧啶类抗癌药物细胞毒性的关键组成部分

Ying Yu Liang, Smaranda Bacanu, Lekshmy Sreekumar, Anderson Daniel Ramos, Lingyun Dai, Martin Michaelis, Jindrich Cinatl, Takahiro Seki, Yihai Cao, Cynthia R Coffill, David P Lane, Nayana Prabhu, Pär Nordlund

An Automated Quantification Tool for Angiogenic Sprouting From Endothelial Spheroids

内皮细胞球体血管生成芽生的自动定量工具

Pavitra Kannan, Martin Schain, David P Lane

The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

MDM2抑制剂Navtemadlin可抑制小鼠体内黑色素瘤的生长并增强放射治疗效果

Katrine Ingelshed ,Diana Spiegelberg ,Pavitra Kannan ,Linnéa Påvénius ,Jessica Hacheney ,Long Jiang ,Silke Eisinger ,Danai Lianoudaki ,Dilraj Lama ,Francisca Castillo ,Cecilia Bosdotter ,Warren W Kretzschmar ,Omayma Al-Radi ,Nicolas Fritz ,Eduardo J Villablanca ,Mikael C I Karlsson ,Fredrik Wermeling ,Marika Nestor ,David P Lane ,Saikiran K Sedimbi