日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel immunotherapeutics against LGR5 to target multiple cancer types

针对LGR5的新型免疫疗法可用于治疗多种癌症

Hung-Chang Chen # ,Nico Mueller # ,Katherine Stott ,Chrysa Kapeni ,Eilidh Rivers ,Carolin M Sauer ,Flavio Beke ,Stephen J Walsh ,Nicola Ashman ,Louise O'Brien ,Amir Rafati Fard ,Arman Ghodsinia ,Changtai Li ,Fadwa Joud ,Olivier Giger ,Inti Zlobec ,Ioana Olan ,Sarah J Aitken ,Matthew Hoare ,Richard Mair ,Eva Serrao ,James D Brenton ,Alicia Garcia-Gimenez ,Simon E Richardson ,Brian Huntly ,David R Spring ,Mikkel-Ole Skjoedt ,Karsten Skjødt ,Marc de la Roche ,Maike de la Roche

The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance

人类质子泵抑制剂抑制结核分枝杆菌利福平外排和巨噬细胞诱导的利福平耐受性

M Alexandra Lake, Kristin N Adams, Feilin Nie, Elaine Fowler, Amit K Verma, Silvia Dei, Elisabetta Teodori, David R Sherman, Paul H Edelstein, David R Spring, Mark Troll, Lalita Ramakrishnan

Energetics of lipid transport by the ABC transporter MsbA is lipid dependent

ABC 转运蛋白 MsbA 的脂质运输能量学依赖于脂质

Dawei Guo, Himansha Singh, Atsushi Shimoyama, Charlotte Guffick, Yakun Tang, Sam M Rowe, Timothy Noel, David R Spring, Koichi Fukase, Hendrik W van Veen

Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells

羟基化鱼藤类化合物选择性抑制前列腺癌细胞增殖

David A Russell, Hannah R Bridges, Riccardo Serreli, Sarah L Kidd, Natalia Mateu, Thomas J Osberger, Hannah F Sore, Judy Hirst, David R Spring

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

polo 样激酶 PLK1 的 polo-box 结构域中的隐秘疏水口袋调节底物识别和有丝分裂染色体分离

Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman

Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

开发一种新型细胞通透性蛋白质-蛋白质相互作用抑制剂,用于 Polo 样激酶 1 的 Polo-box 结构域

David J Huggins, Bryn S Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J Narvaez, Meredith Roberts-Thomson, Alex T Crooks, Robert G Boyle, Richard Boyce, David W Walker, Natalia Mateu, Grahame J McKenzie, David R Spring, Ashok R Venkitaraman

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

通过小分子抑制剂对 AURKA 激酶活性进行变构调节,抑制其与 TPX2 的蛋白质-蛋白质相互作用

Matej Janeček, Maxim Rossmann, Pooja Sharma, Amy Emery, David J Huggins, Simon R Stockwell, Jamie E Stokes, Yaw S Tan, Estrella Guarino Almeida, Bryn Hardwick, Ana J Narvaez, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman

Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence

结构和量热研究表明,肝细胞核因子 1β (HNF1β) 转录因子通过单部分 NLS 序列进入细胞核

Mareike M Wiedmann, Shintaro Aibara, David R Spring, Murray Stewart, James D Brenton