日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Outcomes of total elbow arthroplasty in trauma patients compared with patients following fixation of distal humerus fractures

创伤患者行全肘关节置换术与肱骨远端骨折内固定术后患者的疗效比较

Maman, David; Ron, Itay; Weishahe, Nada; Keren, Yaniv; Yelton, Mitchell; Trior, Yaniv; Apt, Elad; Peskin, Bezalel; Ghrayeb, Nabil; Norman, Doron; Shapira, Jacob

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

在粘蛋白产生细胞中,IRE1β 介导的未折叠蛋白反应受到伴侣 AGR2 的抑制

Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

全基因组 CRISPR/Cas9 筛选鉴定出钙网蛋白是 ATF6α 的选择性抑制因子

Joanne Tung, Lei Huang, Ginto George, Heather P Harding, David Ron, Adriana Ordonez

Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells

利用衍生 CRISPR-Cas9 文库从分选固定细胞的基因组 DNA 中迭代富集整合的 sgRNA 的方案

Adriana Ordóñez ,David Ron ,Heather P Harding

Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases

SDS22 和 I3 的交替结合和 p97 介导的解离使活性 PP1 在全磷酸酶之间循环

Anja F Kueck, Johannes van den Boom, Sandra Koska, David Ron, Hemmo Meyer

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response

通过 eIF2γ 进行底物募集可增强全磷酸酶的催化效率,从而终止综合应激反应

Yahui Yan, Maithili Shetty, Heather P Harding, Ginto George, Alisa Zyryanova, Katherine Labbé, Amirhossein Mafi, Qi Hao, Carmela Sidrauski, David Ron

Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP

人类内质网分子伴侣 BiP AMPylation 失调导致婴儿期发病的糖尿病

Luke A Perera #, Andrew T Hattersley #, Heather P Harding #, Matthew N Wakeling #, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron #, Elisa De Franco #

A non-hallucinogenic psychedelic analogue with therapeutic potential

一种具有治疗潜力的非致幻性迷幻剂类似物

Cameron, Lindsay P; Tombari, Robert J; Lu, Ju; Pell, Alexander J; Hurley, Zefan Q; Ehinger, Yann; Vargas, Maxemiliano V; McCarroll, Matthew N; Taylor, Jack C; Myers-Turnbull, Douglas; Liu, Taohui; Yaghoobi, Bianca; Laskowski, Lauren J; Anderson, Emilie I; Zhang, Guoliang; Viswanathan, Jayashri; Brown, Brandon M; Tjia, Michelle; Dunlap, Lee E; Rabow, Zachary T; Fiehn, Oliver; Wulff, Heike; McCorvy, John D; Lein, Pamela J; Kokel, David; Ron, Dorit; Peters, Jamie; Zuo, Yi; Olson, David E

Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

脱AMPylation复合物的结构合理化了FICD拮抗催化活性之间的转换

Luke A Perera, Steffen Preissler, Nathan R Zaccai, Sylvain Prévost, Juliette M Devos, Michael Haertlein, David Ron

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

ISRIB 通过变构拮抗磷酸化 eIF2 对 eIF2B 的抑制作用来减弱综合应激反应

Alisa F Zyryanova, Kazuhiro Kashiwagi, Claudia Rato, Heather P Harding, Ana Crespillo-Casado, Luke A Perera, Ayako Sakamoto, Madoka Nishimoto, Mayumi Yonemochi, Mikako Shirouzu, Takuhiro Ito, David Ron