日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung Cancer

CRISPR 筛选确定了非小细胞肺癌对 KRASG12C 和 SHP2 抑制剂组合的耐药机制

Anirudh Prahallad #, Andreas Weiss #, Hans Voshol, Grainne Kerr, Kathleen Sprouffske, Tina Yuan, David Ruddy, Morgane Meistertzheim, Malika Kazic-Legueux, Tina Kottarathil, Michelle Piquet, Yichen Cao, Laetitia Martinuzzi-Duboc, Alexandra Buhles, Flavia Adler, Salvatore Mannino, Luca Tordella, Laure

CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses

CRISPR 筛选可识别 CD3 双特异性抗体反应的 T 细胞内在调节剂

Ryan D Molony, Theresa Funk, Gina Trabucco, Erik Corcoran, David Ruddy, Malini Varadarajan, GiNell Elliot, Michelle Piquet, Joni Lam, Matthew J Meyer, Hui Qin Wang, Sema Kurtulus, Haihui Lu

Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms

靶向 ASNS 联合 l-天冬酰胺酶治疗实体肿瘤的疗效评估及耐药机制研究

Verena Apfel, Damien Begue, Valentina Cordo', Laura Holzer, Laetitia Martinuzzi, Alexandra Buhles, Grainne Kerr, Ines Barbosa, Ulrike Naumann, Michelle Piquet, David Ruddy, Andreas Weiss, Stephane Ferretti, Reinaldo Almeida, Debora Bonenfant, Luca Tordella, Giorgio G Galli

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

SHP2阻断通过肿瘤细胞内在和外在机制增强抗肿瘤免疫力。

Ye Wang ,Morvarid Mohseni ,Angelo Grauel ,Javier Estrada Diez ,Wei Guan ,Simon Liang ,Jiyoung Elizabeth Choi ,Minying Pu ,Dongshu Chen ,Tyler Laszewski ,Stephanie Schwartz ,Jane Gu ,Leandra Mansur ,Tyler Burks ,Lauren Brodeur ,Roberto Velazquez ,Steve Kovats ,Bhavesh Pant ,Giri Buruzula ,Emily Deng ,Julie T Chen ,Farid Sari-Sarraf ,Christina Dornelas ,Malini Varadarajan ,Haiyan Yu ,Chen Liu ,Joanne Lim ,Huai-Xiang Hao ,Xiaomo Jiang ,Anthony Malamas ,Matthew J LaMarche ,Felipe Correa Geyer ,Margaret McLaughlin ,Carlotta Costa ,Joel Wagner ,David Ruddy ,Pushpa Jayaraman ,Nathaniel D Kirkpatrick ,Pu Zhang ,Oleg Iartchouk ,Kimberly Aardalen ,Viviana Cremasco ,Glenn Dranoff ,Jeffrey A Engelman ,Serena Silver ,Hongyun Wang ,William D Hastings # ,Silvia Goldoni #

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

TGFβ阻断揭示了肿瘤基质的可塑性,表现为存在一类经干扰素激活的成纤维细胞。

Angelo L Grauel ,Beverly Nguyen ,David Ruddy ,Tyler Laszewski ,Stephanie Schwartz ,Jonathan Chang ,Julie Chen ,Michelle Piquet ,Marc Pelletier ,Zheng Yan ,Nathaniel D Kirkpatrick ,Jincheng Wu ,Antoine deWeck ,Markus Riester ,Matt Hims ,Felipe Correa Geyer ,Joel Wagner ,Kenzie MacIsaac ,James Deeds ,Rohan Diwanji ,Pushpa Jayaraman ,Yenyen Yu ,Quincey Simmons ,Shaobu Weng ,Alina Raza ,Brian Minie ,Mirek Dostalek ,Pavitra Chikkegowda ,Vera Ruda ,Oleg Iartchouk ,Naiyan Chen ,Raphael Thierry ,Joseph Zhou ,Iulian Pruteanu-Malinici ,Claire Fabre ,Jeffrey A Engelman ,Glenn Dranoff ,Viviana Cremasco

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

SHP2 抑制可恢复对 ALK 抑制剂有耐药性的 ALK 重排非小细胞肺癌的敏感性

Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour, Katherine X Shaw, Satoshi Yoda, Grainne Kerr, Kristine Yu, Jinsheng Liang, Yichen Cao, Yan Chen, Michael S Lawrence, Adam Langenbucher, Justin F Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T Myers, Emma Labrot, David Ruddy, Melissa Park

Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer

抑制酪蛋白激酶 1 Alpha 可预防 EGFR 突变型非小细胞肺癌患者对厄洛替尼产生获得性耐药性

Alexandra B Lantermann, Dongshu Chen, Kaitlin McCutcheon, Greg Hoffman, Elizabeth Frias, David Ruddy, Daniel Rakiec, Joshua Korn, Gregory McAllister, Frank Stegmeier, Matthew J Meyer, Sreenath V Sharma

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition

靶向 HSF1 可使癌细胞对 HSP90 抑制敏感

Yaoyu Chen, Jinyun Chen, Alice Loo, Savina Jaeger, Linda Bagdasarian, Jianjun Yu, Franklin Chung, Joshua Korn, David Ruddy, Ribo Guo, Margaret E McLaughlin, Fei Feng, Ping Zhu, Frank Stegmeier, Raymond Pagliarini, Dale Porter, Wenlai Zhou

Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis

干扰素调节因子8调节髓系细胞和结核病中的抗原呈递途径

Marquis, Jean-François; Kapoustina, Oxana; Langlais, David; Ruddy, Rebecca; Dufour, Catherine Rosa; Kim, Bae-Hoon; MacMicking, John D; Giguère, Vincent; Gros, Philippe