日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules

EML2-S 构成了一类新型蛋白质,能够识别并调节酪氨酸化微管的动态变化。

Takashi Hotta ,Thomas S McAlear ,Yang Yue ,Takumi Higaki ,Sarah E Haynes ,Alexey I Nesvizhskii ,David Sept ,Kristen J Verhey ,Susanne Bechstedt ,Ryoma Ohi

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding

驱动蛋白结合蛋白重塑驱动蛋白马达以防止微管结合

April L Solon, Zhenyu Tan, Katherine L Schutt, Lauren Jepsen, Sarah E Haynes, Alexey I Nesvizhskii, David Sept, Jason Stumpff, Ryoma Ohi, Michael A Cianfrocco

Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin

小白菊内酯通过共价修饰微管蛋白来破坏微管稳定性

Takashi Hotta ,Sarah E Haynes ,Teresa L Blasius ,Margo Gebbie ,Emily L Eberhardt ,David Sept ,Michael Cianfrocco ,Kristen J Verhey ,Alexey I Nesvizhskii ,Ryoma Ohi

Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

驱动蛋白-3马达KIF1A的致病突变通过变构机制减弱动力产生和运动。

Breane G Budaitis # ,Shashank Jariwala # ,Lu Rao # ,Yang Yue ,David Sept ,Kristen J Verhey ,Arne Gennerich

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

颈部接头对接对于细胞中的 Kinesin-1 力产生至关重要,但会以牺牲运动速度和加工性为代价

Breane G Budaitis, Shashank Jariwala #, Dana N Reinemann #, Kristin I Schimert #, Guido Scarabelli, Barry J Grant, David Sept, Matthew J Lang, Kristen J Verhey

Real-time shape approximation and fingerprinting of single proteins using a nanopore

使用纳米孔对单个蛋白质进行实时形状近似和指纹识别

Erik C Yusko, Brandon R Bruhn, Olivia M Eggenberger, Jared Houghtaling, Ryan C Rollings, Nathan C Walsh, Santoshi Nandivada, Mariya Pindrus, Adam R Hall, David Sept, Jiali Li, Devendra S Kalonia, Michael Mayer

Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine

紫杉醇和长春花碱药物的动力学稳定机制

Brian T Castle, Seth McCubbin, Louis S Prahl, Jordan N Bernens, David Sept, David J Odde

Novel α-tubulin mutation disrupts neural development and tubulin proteostasis

新的 α-微管蛋白突变破坏神经发育和微管蛋白稳态

M Gartz Hanson, Jayne Aiken, Daniel V Sietsema, David Sept, Emily A Bates, Lee Niswander, Jeffrey K Moore

Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes

水凝胶辅助巨型脂质体中人类 P-糖蛋白 (ABCB1) 的功能重建

Kim S Horger, Haiyan Liu, Divya K Rao, Suneet Shukla, David Sept, Suresh V Ambudkar, Michael Mayer

A method for multiprotein assembly in cells reveals independent action of kinesins in complex

细胞内多蛋白组装的方法揭示了复合体中驱动蛋白的独立作用

Stephen R Norris, Virupakshi Soppina, Aslan S Dizaji, Kristin I Schimert, David Sept, Dawen Cai, Sivaraj Sivaramakrishnan, Kristen J Verhey