日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

作者更正:靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Khoury, Nathalie; Pizzo, Michelle E; Discenza, Claire B; Joy, David; Tatarakis, David; Todorov, Mihail Ivilinov; Negwer, Moritz; Ha, Connie; De Melo, Gabrielly L; Sarrafha, Lily; Simon, Matthew J; Chan, Darren; Chau, Roni; Chew, Kylie S; Chow, Johann; Clemens, Allisa; Robles-Colmenares, Yaneth; Dugas, Jason C; Duque, Joseph; Kaltenecker, Doris; Kane, Holly; Leung, Amy; Lozano, Edwin; Moshkforoush, Arash; Roche, Elysia; Sandmann, Thomas; Tong, Mabel; Xa, Kaitlin; Zhou, Yinhan; Lewcock, Joseph W; Ertürk, Ali; Thorne, Robert G; Calvert, Meredith E K; Yu Zuchero, Y Joy

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Nathalie Khoury,Michelle E Pizzo,Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha,Gabrielly L De Melo,Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow,Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker,Holly Kane,Amy Leung,Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk,Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

Cohesin composition and dosage independently affect early development in zebrafish

黏连蛋白的组成和剂量独立地影响斑马鱼的早期发育

Anastasia A Labudina, Michael Meier, Gregory Gimenez, David Tatarakis, Sarada Ketharnathan, Bridget Mackie, Thomas F Schilling, Jisha Antony, Julia A Horsfield

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Single-cell transcriptomic analysis of zebrafish cranial neural crest reveals spatiotemporal regulation of lineage decisions during development

斑马鱼颅神经嵴单细胞转录组分析揭示发育过程中谱系决定的时空调控

David Tatarakis ,Zixuan Cang ,Xiaojun Wu ,Praveer P Sharma ,Matthew Karikomi ,Adam L MacLean ,Qing Nie ,Thomas F Schilling