日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

通过跨谱系免疫库挖掘快速优化抗TREM2临床先导抗体的亲和力

Yi-Chun Hsiao ,Heidi Ackerly Wallweber ,Robert G Alberstein ,Zhonghua Lin ,Changchun Du ,Ainhoa Etxeberria ,Theint Aung ,Yonglei Shang ,Dhaya Seshasayee ,Franziska Seeger ,Andrew M Watkins ,David V Hansen ,Christopher J Bohlen ,Peter L Hsu ,Isidro Hötzel

Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer's Disease and Multiple Sclerosis

TREM2激动剂抗体在阿尔茨海默病和多发性硬化症临床前模型中的中性或有害作用

Ainhoa Etxeberria ,Yun-An A Shen ,Stephen Vito ,Sean M Silverman ,Jose Imperio ,Guita Lalehzadeh ,Allison L Soung ,Changchun Du ,Luke Xie ,Man Kin Choy ,Yi-Chun Hsiao ,Hai Ngu ,Chang Hoon Cho ,Soumitra Ghosh ,Gloriia Novikova ,Mitchell G Rezzonico ,Rebecca Leahey ,Martin Weber ,Alvin Gogineni ,Justin Elstrott ,Monica Xiong ,Jacob J Greene ,Kimberly L Stark ,Pamela Chan ,Gillie A Roth ,Max Adrian ,Qingling Li ,Meena Choi ,Weng Ruh Wong ,Wendy Sandoval ,Oded Foreman ,Alicia A Nugent ,Brad A Friedman ,Shraddha Sadekar ,Isidro Hötzel ,David V Hansen ,Ben Chih ,Tracy J Yuen ,Robby M Weimer ,Amy Easton ,William J Meilandt ,Christopher J Bohlen

TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease

阿尔茨海默病小鼠模型中 TREM2 独立的少突胶质细胞、星形胶质细胞和 T 细胞对 tau 和淀粉样蛋白病理的反应

Seung-Hye Lee, Mitchell G Rezzonico, Brad A Friedman, Melanie H Huntley, William J Meilandt, Shristi Pandey, Ying-Jiun J Chen, Amy Easton, Zora Modrusan, David V Hansen, Morgan Sheng, Christopher J Bohlen

Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

阿尔茨海默病患者的小胶质细胞表现出增强的衰老和独特的转录激活

Karpagam Srinivasan, Brad A Friedman, Ainhoa Etxeberria, Melanie A Huntley, Marcel P van der Brug, Oded Foreman, Jonathan S Paw, Zora Modrusan, Thomas G Beach, Geidy E Serrano, David V Hansen

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

Trem2基因缺失可减少PS2APP阿尔茨海默病小鼠模型中晚期淀粉样斑块的积累,提高Aβ42/Aβ40比值,并加剧轴突营养不良和树突棘丢失。

William J Meilandt ,Hai Ngu ,Alvin Gogineni ,Guita Lalehzadeh ,Seung-Hye Lee ,Karpagam Srinivasan ,Jose Imperio ,Tiffany Wu ,Martin Weber ,Agatha J Kruse ,Kimberly L Stark ,Pamela Chan ,Mandy Kwong ,Zora Modrusan ,Brad A Friedman ,Justin Elstrott ,Oded Foreman ,Amy Easton ,Morgan Sheng ,David V Hansen

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

补体 C3 在人类 AD 脑中被激活,并且是淀粉样变性和 Tau 蛋白病小鼠模型中神经变性所必需的

Tiffany Wu, Borislav Dejanovic, Vineela D Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H Barck, Maya Stark, Hai Ngu, Oded Foreman, William J Meilandt, Justin Elstrott, Michael C Chang, David V Hansen, R

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

配对免疫球蛋白样 2 型受体 Alpha G78R 变体可改变配体结合并对阿尔茨海默病提供保护

Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

前颗粒蛋白缺乏导致自噬受损和 TDP-43 积累

Michael C Chang, Karpagam Srinivasan, Brad A Friedman, Eric Suto, Zora Modrusan, Wyne P Lee, Joshua S Kaminker, David V Hansen, Morgan Sheng

A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains

IL-6R 的一种常见变体与阿尔茨海默病患者大脑中 IL-6 通路活性升高有关

Patrick C G Haddick ,Jessica L Larson ,Nisha Rathore ,Tushar R Bhangale ,Qui T Phung ,Karpagam Srinivasan ,David V Hansen ,Jennie R Lill ,Jonathan Haines ,Lindsay A Farrer ,John S Kauwe ,Gerard D Schellenberg ,Carlos Cruchaga ,Alison M Goate ,Timothy W Behrens ,Ryan J Watts ,Robert R Graham ,Joshua S Kaminker ,Marcel van der Brug

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

解开大脑的神经炎症和神经退行性转录反应

Karpagam Srinivasan, Brad A Friedman, Jessica L Larson, Benjamin E Lauffer, Leonard D Goldstein, Laurie L Appling, Jovencio Borneo, Chungkee Poon, Terence Ho, Fang Cai, Pascal Steiner, Marcel P van der Brug, Zora Modrusan, Joshua S Kaminker, David V Hansen