日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats

NLS 结合缺陷的 Kapβ2 通过与 C9orf72-ALS/FTD 二肽重复序列选择性相互作用降低神经毒性

Kevin M Kim #, Amandeep Girdhar #, Maria E Cicardi #, Vaishnavi Kankate, Miyuki Hayashi, Ruoyu Yang, Jenny L Carey, Charlotte M Fare, James Shorter, Gino Cingolani, Davide Trotti, Lin Guo

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification

ARID1A-BAF 协调 ZIC2 基因组占据,实现颅神经嵴规范中的上皮-间质转化

Samantha M Barnada, Aida Giner de Gracia, Cruz Morenilla-Palao, Maria Teresa López-Cascales, Chiara Scopa, Francis J Waltrich Jr, Harald M M Mikkers, Maria Elena Cicardi, Jonathan Karlin, Davide Trotti, Kevin A Peterson, Samantha A Brugmann, Gijs W E Santen, Steven B McMahon, Eloísa Herrera, Marco T

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes

葡萄糖代谢减慢会促进 RAN 翻译并加剧 C9orf72 相关的 ALS/FTD 表型

Andrew T Nelson #, Maria Elena Cicardi #, Shashirekha S Markandaiah, John Ys Han, Nancy J Philp, Emily Welebob, Aaron R Haeusler, Piera Pasinelli, Giovanni Manfredi, Hibiki Kawamata, Davide Trotti

JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer's disease

JUN 上调导致异常转座因子动员、相关先天免疫反应以及阿尔茨海默病中的神经发生受损

Chiara Scopa, Samantha M Barnada, Maria E Cicardi, Mo Singer, Davide Trotti, Marco Trizzino

Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia

家族性肌萎缩侧索硬化症-额颞叶痴呆症中 PML 核体的丢失

Francesco Antoniani #, Marco Cimino #, Laura Mediani, Jonathan Vinet, Enza M Verde, Valentina Secco, Alfred Yamoah, Priyanka Tripathi, Eleonora Aronica, Maria E Cicardi, Davide Trotti, Jared Sterneckert, Anand Goswami, Serena Carra

Differential response of C9orf72 transcripts following neuronal depolarization

神经元去极化后 C9orf72 转录物的差异反应

Layla T Ghaffari, Davide Trotti, Aaron R Haeusler

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility

NUP62 定位于 ALS/FTLD 病理组装体并导致 TDP-43 不溶性

Amanda M Gleixner, Brandie Morris Verdone, Charlton G Otte, Eric N Anderson, Nandini Ramesh, Olivia R Shapiro, Jenna R Gale, Jocelyn C Mauna, Jacob R Mann, Katie E Copley, Elizabeth L Daley, Juan A Ortega, Maria Elena Cicardi, Evangelos Kiskinis, Julia Kofler, Udai B Pandey, Davide Trotti, Christoph

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice

靶向表达与肉瘤融合的肌萎缩侧索硬化症相关突变的星形胶质细胞产生的 TNFα 可预防小鼠的神经退行性病变和运动功能障碍

Brigid K Jensen, Kevin J McAvoy, Nicolette M Heinsinger, Angelo C Lepore, Hristelina Ilieva, Aaron R Haeusler, Davide Trotti, Piera Pasinelli

A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes

一种广泛表达C9orf72连接的甘氨酸-精氨酸二肽的小鼠模型表现出非致命的ALS/FTD样表型。

Brandie Morris Verdone ,Maria Elena Cicardi ,Xinmei Wen ,Sindhu Sriramoji ,Katelyn Russell ,Shashirekha S Markandaiah ,Brigid K Jensen ,Karthik Krishnamurthy ,Aaron R Haeusler ,Piera Pasinelli ,Davide Trotti

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment

SV2 补充可挽救 C9orf72-ALS/FTD 中甘氨酸-丙氨酸二肽引起的突触功能障碍

Brigid K Jensen, Martin H Schuldi, Kevin McAvoy, Katelyn A Russell, Ashley Boehringer, Bridget M Curran, Karthik Krishnamurthy, Xinmei Wen, Thomas Westergard, Le Ma, Aaron R Haeusler, Dieter Edbauer, Piera Pasinelli, Davide Trotti