High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.
高通量筛选发现了一种新型的 Hsp70 小分子调节剂，该调节剂可选择性地增强错误折叠的神经元 NO 合酶的泛素化和降解
期刊:Molecular Pharmacology
影响因子:3
doi:10.1016/j.molpha.2024.100008
Garcia Anthony M, Davis Amanda K, Martinez-Ramos Cristian, Morishima Yoshihiro, Lau Miranda, Xu Emily, Sunil Arya, Zhang Haoming, Alt Andrew, Lieberman Andrew P, Osawa Yoichi
