日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer

负选择维持转移性结直肠癌中显著改变但总体稳定的核型

Cross, William C H; Nowinski, Salpie; Cresswell, George D; Mossner, Maximilian; Banerjee, Abhirup; Lu, Bingxin; Williams, Marc J; Vlachogiannis, Georgios; Gay, Laura J; Baker, Ann-Marie; Kimberley, Christopher; Whiting, Frederick J H; Belnoue-Davis, Hayley L; Martinez, Pierre; Traki, Maria; Walther, Viola; Smith, Kane; Fernandez-Mateos, Javier; Yara-Romero, Erika; Oliveira, Erica A; Milite, Salvatore; Caravagna, Giulio; James, Chela T; Elia, George; Berner, Alison; Ryan Choi, Chang-Ho; Ramagiri, Pradeep; Chauhan, Ritika; Matthews, Nik; Murphy, Jamie; Antoniou, Anthony; Clark, Susan K; Mitchison, Miriam; Chin Aleong, Jo-Anne; Domingo, Enric; Spiteri, Inmaculada; McDonald, Stuart A C; Shibata, Darryl; Laclé, Miangela M; Wang, Lai Mun; Moorghen, Morgan; Tomlinson, Ian P M; Novelli, Marco; Jansen, Marnix; Watson, Alan; Valeri, Nicola; Wright, Nicholas A; Bridgewater, John A; Rodriguez-Justo, Manuel; Barnes, Chris P; Kocher, Hemant M; Leedham, Simon J; Sottoriva, Andrea; Graham, Trevor A

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

结直肠癌肿瘤微环境的治疗性调控和空间定量分析。

Mulholland-Illingworth Eoghan J, Moore Joshua W, Lin Muyang, Amirkhah Raheleh, Grzesiak Lucile, Ligeza Amelia, Bull Joshua A, Boen Joseph, Valbuena Gabriel N, Gillespie Michael A, Lannagan Tamsin R M, Gilroy Kathryn, Mills Megan L, Corry Shania M, Ridgway Rachel A, Belnoue-Davis Hayley L, Dunne Philip D, Sansom Owen J, Byrne Helen M, Leedham Simon J

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.

低覆盖率全基因组测序可以强有力地预测溃疡性结肠炎中低级别发育不良的进展为肿瘤的风险

Al Bakir Ibrahim, Curtius Kit, Cresswell George D, Grant Heather E, Nasreddin Nadia, Smith Kane, Nowinski Salpie, Guo Qingli, Belnoue-Davis Hayley L, Fisher Jennifer, Clarke Theo, Kimberley Christopher, Mossner Maximilian, Dunne Philip D, Loughrey Maurice B, Speight Ally, East James E, Wright Nicholas A, Rodriguez-Justo Manuel, Jansen Marnix, Moorghen Morgan, Baker Ann-Marie, Leedham Simon J, Hart Ailsa L, Graham Trevor A

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.

上皮细胞 GREMLIN1 通过基质重塑破坏肠道上皮-间质细胞间的相互作用,从而诱导 Wnt 依赖性异位干细胞微环境

Mulholland Eoghan J, Belnoue-Davis Hayley L, Valbuena Gabriel N, Gunduz Nuray, Ligeza Amelia, Lin Muyang, Biswas Sujata, Gil Vasquez Ester, Omwenga Sulochana, Nasreddin Nadia, Hodder Michael C, Wang Lai Mun, Ng Aik Seng, Jennings Elizabeth, Midwood Kim S, Dedi Neesha, Irshad Shazia, Ridgway Rachel A, Phesse Toby J, East James, Tomlinson Ian Pm, Davies Gareth Cg, Sansom Owen J, Leedham Simon J

Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer

作者更正:通路水平亚型分析识别出一种与结直肠癌不良临床结局相关的慢周期生物学表型

Malla, Sudhir B; Byrne, Ryan M; Lafarge, Maxime W; Corry, Shania M; Fisher, Natalie C; Tsantoulis, Petros K; Mills, Megan L; Ridgway, Rachel A; Lannagan, Tamsin R M; Najumudeen, Arafath K; Gilroy, Kathryn L; Amirkhah, Raheleh; Maguire, Sarah L; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L; Sakhnevych, Svetlana; McCooey, Aoife J; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B; Kerr, Emma M; Tejpar, Sabine; Maughan, Timothy S; Lawler, Mark; Campbell, Andrew D; Leedham, Simon J; Koelzer, Viktor H; Sansom, Owen J; Dunne, Philip D

Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

功能分析揭示了子宫内膜癌发生过程中驱动基因的协同作用和新的机制

Brown, Matthew; Leon, Alicia; Kedzierska, Katarzyna; Moore, Charlotte; Belnoue-Davis, Hayley L; Flach, Susanne; Lydon, John P; DeMayo, Francesco J; Lewis, Annabelle; Bosse, Tjalling; Tomlinson, Ian; Church, David N

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

结直肠肿瘤中动态和适应性癌症干细胞群的混合

Gil Vazquez, Ester; Nasreddin, Nadia; Valbuena, Gabriel N; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Eggington, Holly R; Schenck, Ryan O; Wouters, Valérie M; Wirapati, Pratyaksha; Gilroy, Kathryn; Lannagan, Tamsin R M; Flanagan, Dustin J; Najumudeen, Arafath K; Omwenga, Sulochana; McCorry, Amy M B; Easton, Alistair; Koelzer, Viktor H; East, James E; Morton, Dion; Trusolino, Livio; Maughan, Timothy; Campbell, Andrew D; Loughrey, Maurice B; Dunne, Philip D; Tsantoulis, Petros; Huels, David J; Tejpar, Sabine; Sansom, Owen J; Leedham, Simon J

Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration.

Grem1通过拮抗骨形态发生蛋白通路调控肠道再生中的上皮细胞命运

Koppens Martijn A J, Davis Hayley, Valbuena Gabriel N, Mulholland Eoghan J, Nasreddin Nadia, Colombe Mathilde, Antanaviciute Agne, Biswas Sujata, Friedrich Matthias, Lee Lennard, Wang Lai Mun, Koelzer Viktor H, East James E, Simmons Alison, Winton Douglas J, Leedham Simon J

Mutant p53s and chromosome 19 microRNA cluster overexpression regulate cancer testis antigen expression and cellular transformation in hepatocellular carcinoma

突变型 p53 和 19 号染色体 microRNA 簇过度表达调节肝细胞癌中的癌睾丸抗原表达和细胞转化

Goodwin G Jinesh, Marco Napoli, Marian T Smallin, Andrew Davis, Hayley D Ackerman, Payal Raulji, Nicole Montey, Elsa R Flores, Andrew S Brohl

Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification

利用Wnt靶基因表达差异生成结直肠癌分层的分子生物标志物

Kleeman, Sam O; Koelzer, Viktor H; Jones, Helen Js; Vazquez, Ester Gil; Davis, Hayley; East, James E; Arnold, Roland; Koppens, Martijn Aj; Blake, Andrew; Domingo, Enric; Cunningham, Chris; Beggs, Andrew D; Pestinger, Valerie; Loughrey, Maurice B; Wang, Lai-Mun; Lannagan, Tamsin Rm; Woods, Susan L; Worthley, Daniel; Consortium, S Cort; Tomlinson, Ian; Dunne, Philip D; Maughan, Timothy; Leedham, Simon J