日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Two-pore channels: going with the flows

双孔通道:顺流而下

Morgan, Anthony J; Martucci, Lora L; Davis, Lianne C; Galione, Antony

NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca(2+) nanodomains, calcineurin and dynamin.

NAADP 调节的双孔通道通过内溶酶体 Ca(2+) 纳米域、钙调磷酸酶和动力蛋白驱动吞噬作用

Davis Lianne C, Morgan Anthony J, Galione Antony

Defective platelet function in Niemann-Pick disease type C1

尼曼-匹克病C1型血小板功能缺陷

Chen, Oscar C W; Colaco, Alexandria; Davis, Lianne C; Kiskin, Fedir N; Farhat, Nicole Y; Speak, Anneliese O; Smith, David A; Morris, Lauren; Eden, Emily; Tynan, Patricia; Churchill, Grant C; Galione, Antony; Porter, Forbes D; Platt, Frances M

Revealing the secrets of secretion

揭开分泌的秘密

Galione, Antony; Davis, Lianne C

Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells

T细胞中NAADP通路与胞吐作用的优先偶联

Davis, Lianne C; Platt, Frances M; Galione, Antony

Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1

小鼠和人类尼曼-匹克病C1型中自然杀伤细胞的分布和功能改变

Speak, Anneliese O; Te Vruchte, Danielle; Davis, Lianne C; Morgan, Anthony J; Smith, David A; Yanjanin, Nicole M; Simmons, Louise; Hartung, Ralf; Runz, Heiko; Mengel, Eugen; Beck, Michael; Imrie, Jackie; Jacklin, Elizabeth; Wraith, James E; Hendriksz, Christian; Lachmann, Robin; Cognet, Celine; Sidhu, Rohini; Fujiwara, Hideji; Ory, Daniel S; Galione, Antony; Porter, Forbes D; Vivier, Eric; Platt, Frances M

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2

TPC1有两种变体亚型,它们的缺失对内溶酶体功能的影响与TPC2缺失的影响不同。

Ruas, Margarida; Chuang, Kai-Ting; Davis, Lianne C; Al-Douri, Areej; Tynan, Patricia W; Tunn, Ruth; Teboul, Lydia; Galione, Antony; Parrington, John

Cytolytic granules supply Ca(2+) for their own exocytosis via NAADP and resident two-pore channels

细胞溶解颗粒通过 NAADP 和其固有的双孔通道提供 Ca(2+) 用于自身的胞吐作用。

Davis, Lianne C; Galione, Antony

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

NAADP激活T细胞细胞溶解颗粒上的双孔通道,从而刺激胞吐作用和杀伤作用。

Davis, Lianne C; Morgan, Anthony J; Chen, Ji-Li; Snead, Charlotte M; Bloor-Young, Duncan; Shenderov, Eugene; Stanton-Humphreys, Megan N; Conway, Stuart J; Churchill, Grant C; Parrington, John; Cerundolo, Vincenzo; Galione, Antony

Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites

Ca(2+)信号传导是通过细胞器内合成位点释放第二信使实现的。

Davis, Lianne C; Morgan, Anthony J; Ruas, Margarida; Wong, Julian L; Graeff, Richard M; Poustka, Albert J; Lee, Hon Cheung; Wessel, Gary M; Parrington, John; Galione, Antony