日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver

慢性酒精摄入对人体肝脏药物代谢酶和转运蛋白组成的影响

Gaither, Kari A; Yue, Guihua; Singh, Dilip Kumar; Trudeau, Julia; Ponraj, Kannapiran; Davydova, Nadezhda Y; Lazarus, Philip; Davydov, Dmitri R; Prasad, Bhagwat

Effects of alcohol consumption and tobacco smoking on the composition of the ensemble of drug metabolizing enzymes and transporters in human liver

饮酒和吸烟对人肝脏药物代谢酶和转运蛋白集合体组成的影响

Gaither, Kari A; Singh, Dilip Kumar; Yue, Guihua; Trudeau, Julia; Ponraj, Kannapiran; Davydova, Nadezhda Y; Lazarus, Philip; Davydov, Dmitri R; Prasad, Bhagwat

Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4

酒精诱导的人肝微粒体中CYP2E1含量增加对CYP3A4活性和协同性的影响

Dangi, Bikash; Davydova, Nadezhda Y; Maldonado, Marc A; Abbasi, Armina; Vavilov, Nikita E; Zgoda, Victor G; Davydov, Dmitri R

Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation

3,4-亚甲二氧基甲基苯丙胺(MDMA)对CYP2D6的时间依赖性抑制的动力学机制:酶的功能异质性及其失活的可逆性

Rodgers, John T; Davydova, Nadezhda Y; Paragas, Erickson M; Jones, Jeffrey P; Davydov, Dmitri R

Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

微粒体膜中细胞色素P450之间的相互作用:细胞色素P450 3A4、3A5和2E1的寡聚化及其功能后果

Davydov, Dmitri R; Davydova, Nadezhda Y; Sineva, Elena V; Halpert, James R

Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

P450-P450相互作用在CYP3A4变构中的关键作用:以α-萘黄酮为例

Davydov, Dmitri R; Davydova, Nadezhda Y; Sineva, Elena V; Kufareva, Irina; Halpert, James R

CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450

来自深海细菌的CYP261酶:揭示细胞色素P450构象异质性的线索

Davydov, Dmitri R; Sineva, Elena V; Davydova, Nadezhda Y; Bartlett, Douglas H; Halpert, James R

Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET).

利用荧光共振能量转移(FRET)定位细胞色素 P450 3A4 的外周配体结合位点

Davydov Dmitri R, Rumfeldt Jessica A O, Sineva Elena V, Fernando Harshica, Davydova Nadezhda Y, Halpert James R

Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity.

细胞色素 P450 3A4 突变体中保留了多个底物结合位点,但协同性降低

Fernando Harshica, Rumfeldt Jessica A O, Davydova Nadezhda Y, Halpert James R, Davydov Dmitri R

Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.

谷胱甘肽对细胞色素 P450 3A4 同型和异型协同作用的影响

Davydov Dmitri R, Davydova Nadezhda Y, Tsalkova Tamara N, Halpert James R