日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma.

靶向 FAK 和 MEK 的药物组合克服了胶质母细胞瘤的肿瘤异质性

Furqan Muhammad, Elliott Richard J R, Nagle Peter W K, Dawson John C, Masalmeh Roza, Garcia Virginia Alvarez, Munro Alison F, Drake Camilla, Morrison Gillian M, Pollard Steven M, Ebner Daniel, Brunton Valerie G, Frame Margaret C, Carragher Neil O

High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma

高通量筛选鉴定组蛋白去乙酰化酶抑制剂在软组织肉瘤患者模型中的活性

Danks, Molly R; Manasterski, Piotr J; Beetham, Henry; Dawson, John C; Elliott, Richard J R; Culley, Jayne; Krishna, Rashi; Muir, Morwenna; Thomson, John P; Oswald, Ailsa J; Ewing, Ailith; Kerrison, William G J; Huang, Paul H; Nixon, Ioanna; Carragher, Neil O; Brunton, Valerie G

Genomics-led approach to drug testing in models of undifferentiated pleomorphic sarcoma

基因组学主导的药物测试方法在未分化多形性肉瘤模型中的应用

Manasterski, Piotr J; Danks, Molly R; Thomson, John P; Muir, Morwenna; Lee, Martin; Dawson, John C; Amaral, Ana T; Diaz-Martin, Juan; Moura, David S; Martin-Broto, Javier; Alsaadi, Ali; Salter, Donald M; Oswald, Ailsa J; Grimes, Graeme; Hayward, Larry; Hupp, Ted R; Sisley, Karen; Huang, Paul H; Carragher, Neil O; Brunton, Valerie G

Cellular Activity of CQWW Nullomer-Derived Peptides

CQWW Nullomer衍生肽的细胞活性

Shave, Steven; Isaksson, Rebecka; Pham, Nhan T; Elliott, Richard J R; Dawson, John C; Soudant, Julius; Carragher, Neil O; Auer, Manfred

A Novel High-Content Phenotypic Screen To Identify Inhibitors of Mitochondrial DNA Maintenance in Trypanosomes

一种新型高通量表型筛选方法用于鉴定锥虫线粒体DNA维持抑制剂

Miskinyte, Migla; Dawson, John C; Makda, Ashraff; Doughty-Shenton, Dahlia; Carragher, Neil O; Schnaufer, Achim

Targeting FAK in anticancer combination therapies

在抗癌联合疗法中靶向FAK

Dawson, John C; Serrels, Alan; Stupack, Dwayne G; Schlaepfer, David D; Frame, Margaret C

Development of a fluorescence-based cellular apoptosis reporter

开发一种基于荧光的细胞凋亡报告基因

Balderstone, Lucy A; Dawson, John C; Welman, Arkadiusz; Serrels, Alan; Wedge, Stephen R; Brunton, Valerie G

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

快速发现并阐明吡唑并嘧啶类化合物的构效关系,该类化合物通过抑制SRC激酶有效抑制乳腺癌细胞生长,且对ABL激酶具有极高的选择性。

Fraser, Craig; Dawson, John C; Dowling, Reece; Houston, Douglas R; Weiss, Jason T; Munro, Alison F; Muir, Morwenna; Harrington, Lea; Webster, Scott P; Frame, Margaret C; Brunton, Valerie G; Patton, E Elizabeth; Carragher, Neil O; Unciti-Broceta, Asier

Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine

吉西他滨钯不稳定前药的开发和生物正交活化

Weiss, Jason T; Dawson, John C; Fraser, Craig; Rybski, Witold; Torres-Sánchez, Carmen; Bradley, Mark; Patton, E Elizabeth; Carragher, Neil O; Unciti-Broceta, Asier

Quantitative phenotypic and pathway profiling guides rational drug combination strategies

定量表型和通路分析指导合理的药物组合策略

Dawson, John C; Carragher, Neil O