日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2

犬尿氨酸的亲电代谢产物犬尿氨酸-CKA需要Keap1中的C151才能解除Nrf2的抑制。

Feng, Jialin; Carreño, Mara; Jung, Hannah; Dayalan Naidu, Sharadha; Arroyo-Diaz, Nicole; Ang, Abel D; Kulkarni, Bhargavi; Kisielewski, Dorothy; Suzuki, Takafumi; Yamamoto, Masayuki; Hayes, John D; Honda, Tadashi; Wilson, Landon; Leon-Ruiz, Beatriz; Eggler, Aimee L; Vitturi, Dario A; Dinkova-Kostova, Albena T

Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment

靶向Keap1-Kelch的蛋白质-蛋白质相互作用抑制剂,而非可逆结合的亲电试剂,能够提高Keap1在细胞环境中的热稳定性。

Dayalan Naidu, Sharadha; Dikovskaya, Dina; Walker, Jasmine M; Yee, Charlotte Lim Jia; Cafferkey, Annamarie J; Tatsuno, Manaka; Feng, Jialin; Moore, Terry W; Johnson, Tatum; Honda, Tadashi; Wells, Geoff; Suzuki, Takafumi; Yamamoto, Masayuki; Dinkova-Kostova, Albena T

Advances in nanomedicine strategies for modulating the tumor microenvironment: Recent progress and clinical perspectives

纳米医学策略在调控肿瘤微环境方面的进展:最新进展和临床展望

Emran, Talha Bin; Al Amin, Md; Rab, Safia Obaidur; Jahnavi, Patibandla; Vodeti, Rajeshwar; Gupta, Jeetendra Kumar; Arjun, Uppuluri Varuna Naga Venkata; Umamaheswari, T N; Balaji, P; Dayalan, Girija; Rani, Soniya; Gupta, Prem Shankar

Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

健康立场文件和氧化还原视角——非传染性疾病中NRF2药物调控的从实验室到临床转化

Cuadrado, Antonio; Cazalla, Eduardo; Bach, Anders; Bathish, Boushra; Naidu, Sharadha Dayalan; DeNicola, Gina M; Dinkova-Kostova, Albena T; Fernández-Ginés, Raquel; Grochot-Przeczek, Anna; Hayes, John D; Kensler, Thomas W; León, Rafael; Liby, Karen T; López, Manuela G; Manda, Gina; Shivakumar, Akshatha Kalavathi; Hakomäki, Henriikka; Moerland, Jessica A; Motohashi, Hozumi; Rojo, Ana I; Sykiotis, Gerasimos P; Taguchi, Keiko; Valverde, Ángela M; Yamamoto, Masayuki; Levonen, Anna-Liisa

Tetrazole-containing naphthalene bis-sulfonamide Keap1-Nrf2 interaction inhibitors with unexpected binding modes.

具有意想不到的结合模式的含四唑萘双磺酰胺 Keap1-Nrf2 相互作用抑制剂。

Georgakopoulos Nikolaos D, Talapatra Sandeep K, Dayalan Naidu Sharadha, Dikovskaya Dina, Higgins Maureen, Gatliff Jemma, Nikoloudaki Roxani, Schaap Marjolein, Walker Jasmine M, Wardby Christopher, Dinkova-Kostova Albena T, Harris Sarah, Kozielski Frank, Wells Geoff

Revolutionizing Cancer Immunotherapy: Emerging Nanotechnology-Driven Drug Delivery Systems for Enhanced Therapeutic Efficacy

革新癌症免疫疗法:新兴纳米技术驱动的药物递送系统提升治疗效果

Theivendren, Panneerselvam; Kunjiappan, Selvaraj; Pavadai, Parasuraman; Ravi, Kaveena; Murugavel, Anusuya; Dayalan, Avinash; Santhana Krishna Kumar, A

Genetic Deletion of RHAMM Alleviates Hepatic Oxidative Stress, Reversing Thyroid Stimulating Hormone Elevation in Male Obese Mice

RHAMM基因缺失可减轻雄性肥胖小鼠的肝脏氧化应激,逆转促甲状腺激素水平升高

Wang, Tianzhen; Sun, Helin; Banah, Ayman K; Weng, Xiong; Dayalan Naidu, Sharadha; Kisielewski, Dot; Ang, Abel; Hayes, John D; Dinkova-Kostova, Albena T; Kang, Li

The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders

肠道菌群-肠-脑连接:神经系统和神经精神疾病研究的新视野

Faysal, Md; Zehravi, Mehrukh; Sutradhar, Baishakhi; Al Amin, Md; Shanmugarajan, Thukani Sathanantham; Arjun, Uppuluri Varuna Naga Venkata; Ethiraj, Susithra; Durairaj, Akiladevi; Dayalan, Girija; Ahamad, Shaik Khadeer; Rab, Safia Obaidur; Raman, Kannan; Emran, Talha Bin

The electrophilic metabolite of kynurenine, kynurenine-CKA, targets C151 in Keap1 to derepress Nrf2

犬尿氨酸的亲电代谢产物犬尿氨酸-CKA靶向Keap1中的C151位点,从而解除Nrf2的抑制。

Feng, Jialin; Carreño, Mara; Jung, Hannah; Naidu, Sharadha Dayalan; Diaz, Nicole Arroyo; Ang, Abel D; Kulkarni, Bhargavi; Kisielewski, Dorothy; Suzuki, Takafumi; Yamamoto, Masayuki; Hayes, John D; Honda, Tadashi; Leon-Ruiz, Beatriz; Eggler, Aimee L; Vitturi, Dario A; Dinkova-Kostova, Albena T

Loss of white matter tracts and persistent microglial activation in the chronic phase of ischemic stroke in female rats and the effect of miR-20a-3p treatment

雌性大鼠缺血性卒中慢性期白质束丢失和持续性小胶质细胞活化以及miR-20a-3p治疗的影响

Sampath, Dayalan; Zardeneta, Macy E; Akbari, Zara; Singer, Jacob; Gopalakrishnan, Balaji; Hurst, David Austin; Villarreal, Monserrat; McDaniel, Erin A; Noarbe, Brenda Patricia; Obenaus, Andre; Sohrabji, Farida