Days相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants

高通量筛选鉴定出一种与长QT综合征相关的KCNQ1变异体的转运校正因子

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.201297

Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R

发表日期：2026

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Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel K(ir)2.1: Discovery of VU6080824

内向整流钾通道 K(ir)2.1 的下一代抑制剂的特性研究：VU6080824 的发现

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.5c00297

Duncan, Renn A; Haymer, Daniel H; Lazarenko, Roman M; Li, Liangping; Blackwell, Yvette; Days, Emily L; Krishnan, Srinivasan; Gray, Analisa Thompson; Boutaud, Olivier; Engers, Darren W; Lindsley, Craig W; Denton, Jerod S; Bender, Aaron M

发表日期：2025

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High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants

高通量筛选鉴定出一种针对长QT综合征相关KCNQ1变异的小分子转运校正剂

doi:10.1101/2025.10.13.682066

Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R

发表日期：2025

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Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B K(ATP) Channels

VU0542270 的发现与表征：首个血管 Kir6.1/SUR2B K(ATP) 通道选择性抑制剂

期刊:Molecular Pharmacology

doi:10.1124/molpharm.123.000783

Li, Kangjun; McClenahan, Samantha J; Han, Changho; Bungard, Joseph D; Rathnayake, Upendra; Boutaud, Olivier; Bauer, Joshua A; Days, Emily L; Lindsley, Craig W; Shelton, Elaine L; Denton, Jerod S

发表日期：2024

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A High-Throughput Immune-Oncology Screen Identifies Immunostimulatory Properties of Cytotoxic Chemotherapy Agents in TNBC

高通量免疫肿瘤学筛选确定了 TNBC 中细胞毒性化疗药物的免疫刺激特性

doi:10.3390/cancers16234075

Kennady K Bullock, Thomas Hasaka, Emily Days, Joshua A Bauer, Patricia A Ward, Ann Richmond

发表日期：2024

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Modulation of Uptake and Reactivity of Nitrogen Dioxide in Metal-Organic Framework Materials

金属有机框架材料对二氧化氮吸收和反应性的调控

期刊:Angewandte Chemie-International Edition

影响因子:16.9

doi:10.1002/anie.202302602

Wang, Zi; Sheveleva, Alena M; Lee, Daniel; Chen, Yinlin; Iuga, Dinu; Franks, W Trent; Ma, Yujie; Li, Jiangnan; Li, Lei; Cheng, Yongqiang; Daemen, Luke L; Days, Sarah J; Ramirez-Cuesta, Anibal J; Han, Bing; Eggeman, Alexander S; McInnes, Eric J L; Tuna, Floriana; Yang, Sihai; Schröder, Martin

发表日期：2023

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Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

通过高通量筛选鉴定出一种新型 Kir6.2/SUR1 通道开放剂骨架，并对其合成和构效关系进行了研究。

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2023.129256

Dodd, Cayden J; Chronister, Keagan S; Rathnayake, Upendra; Parr, Lauren C; Li, Kangjun; Chang, Sichen; Mi, Dehui; Days, Emily L; Bauer, Joshua A; Cho, Hyekyung P; Boutaud, Olivier; Denton, Jerod S; Lindsley, Craig W; Han, Changho

发表日期：2023

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Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen

通过高通量筛选鉴定有效、选择性且外周受限的 5-羟色胺受体 2B 拮抗剂

期刊:ASSAY and Drug Development Technologies

影响因子:1.6

doi:10.1089/adt.2022.116

Aaron M Bender, Michael S Valentine, Joshua A Bauer, Emily Days, Craig W Lindsley, W David Merryman

发表日期：2023

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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

精子特异性钾通道 SLO3 的选择性抑制剂会损害人类精子功能

期刊:Proceedings of the National Academy of Sciences of the United States of America

doi:10.1073/pnas.2212338120

Maximilian Lyon, Ping Li, Juan J Ferreira, Roman M Lazarenko, Sujay V Kharade, Meghan Kramer, Samantha J McClenahan, Emily Days, Joshua A Bauer, Brittany D Spitznagel, C David Weaver, Aluet Borrego Alvarez, Lis C Puga Molina, Pascale Lybaert, Saayli Khambekar, Alicia Liu, Craig W Lindsley, Jerod Den

发表日期：2023

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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

VU6036720：首个高效选择性异源Kir4.1/5.1内向整流钾通道体外抑制剂

期刊:Molecular Pharmacology

doi:10.1124/molpharm.121.000464

McClenahan, Samantha J; Kent, Caitlin N; Kharade, Sujay V; Isaeva, Elena; Williams, Jade C; Han, Changho; Terker, Andrew; Gresham, Robert 3rd; Lazarenko, Roman M; Days, Emily L; Romaine, Ian M; Bauer, Joshua A; Boutaud, Olivier; Sulikowski, Gary A; Harris, Raymond; Weaver, C David; Staruschenko, Alexander; Lindsley, Craig W; Denton, Jerod S

发表日期：2022

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