日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants

高通量筛选鉴定出一种与长QT综合征相关的KCNQ1变异体的转运校正因子

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.201297
Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R
发表日期：2026
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Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel K(ir)2.1: Discovery of VU6080824

内向整流钾通道 K(ir)2.1 的下一代抑制剂的特性研究：VU6080824 的发现

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00297
Duncan, Renn A; Haymer, Daniel H; Lazarenko, Roman M; Li, Liangping; Blackwell, Yvette; Days, Emily L; Krishnan, Srinivasan; Gray, Analisa Thompson; Boutaud, Olivier; Engers, Darren W; Lindsley, Craig W; Denton, Jerod S; Bender, Aaron M
发表日期：2025
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High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants

高通量筛选鉴定出一种针对长QT综合征相关KCNQ1变异的小分子转运校正剂

期刊:
影响因子:
doi:10.1101/2025.10.13.682066
Moster, Katherine R Clowes; Vanoye, Carlos G; Chang-Gonzalez, Ana C; Romaine, Ian M; Stefanski, Katherine M; Wilkinson, Mason C; Bauer, Joshua A; Hasaka, Thomas P; Days, Emily L; Desai, Reshma R; Butcher, Kathryn R; Sulikowski, Gary A; Waterson, Alex G; Meiler, Jens; Ledwitch, Kaitlyn V; George, Alfred L Jr; Sanders, Charles R
发表日期：2025
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Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B K(ATP) Channels

VU0542270 的发现与表征：首个血管 Kir6.1/SUR2B K(ATP) 通道选择性抑制剂

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/molpharm.123.000783
Li, Kangjun; McClenahan, Samantha J; Han, Changho; Bungard, Joseph D; Rathnayake, Upendra; Boutaud, Olivier; Bauer, Joshua A; Days, Emily L; Lindsley, Craig W; Shelton, Elaine L; Denton, Jerod S
发表日期：2024
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Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

通过高通量筛选鉴定出一种新型 Kir6.2/SUR1 通道开放剂骨架，并对其合成和构效关系进行了研究。

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2023.129256
Dodd, Cayden J; Chronister, Keagan S; Rathnayake, Upendra; Parr, Lauren C; Li, Kangjun; Chang, Sichen; Mi, Dehui; Days, Emily L; Bauer, Joshua A; Cho, Hyekyung P; Boutaud, Olivier; Denton, Jerod S; Lindsley, Craig W; Han, Changho
发表日期：2023
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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

VU6036720：首个高效选择性异源Kir4.1/5.1内向整流钾通道体外抑制剂

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/molpharm.121.000464
McClenahan, Samantha J; Kent, Caitlin N; Kharade, Sujay V; Isaeva, Elena; Williams, Jade C; Han, Changho; Terker, Andrew; Gresham, Robert 3rd; Lazarenko, Roman M; Days, Emily L; Romaine, Ian M; Bauer, Joshua A; Boutaud, Olivier; Sulikowski, Gary A; Harris, Raymond; Weaver, C David; Staruschenko, Alexander; Lindsley, Craig W; Denton, Jerod S
发表日期：2022
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An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria

一种针对寨卡病毒和疟疾媒介中内向整流钾通道的抗药性蚊子杀虫剂

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/srep36954
Swale, Daniel R; Engers, Darren W; Bollinger, Sean R; Gross, Aaron; Inocente, Edna Alfaro; Days, Emily; Kanga, Fariba; Johnson, Reed M; Yang, Liu; Bloomquist, Jeffrey R; Hopkins, Corey R; Piermarini, Peter M; Denton, Jerod S
微生物学
疟疾
发表日期：2016
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Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.

二氢噻唑并吡啶酮衍生物作为代谢型谷氨酸 5 (mGlu5) 受体的一类新型正向变构调节剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm400650w
Bartolomé-Nebreda José Manuel, Conde-Ceide Susana, Delgado Francisca, Iturrino Laura, Pastor Joaquín, Pena Miguel Ángel, Trabanco Andrés A, Tresadern Gary, Wassvik Carola M, Stauffer Shaun R, Jadhav Satyawan, Gogi Kiran, Vinson Paige N, Noetzel Meredith J, Days Emily, Weaver C David, Lindsley Craig W, Niswender Colleen M, Jones Carrie K, Conn P Jeffrey, Rombouts Frederik, Lavreysen Hilde, Macdonald Gregor J, Mackie Claire, Steckler Thomas
代谢
发表日期：2013
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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function

选择性正向变构调节剂对代谢型谷氨酸受体5亚型的变构激动剂活性在调节中枢神经系统功能中的功能影响

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/mol.111.075184
Noetzel, Meredith J; Rook, Jerri M; Vinson, Paige N; Cho, Hyekyung P; Days, Emily; Zhou, Y; Rodriguez, Alice L; Lavreysen, Hilde; Stauffer, Shaun R; Niswender, Colleen M; Xiang, Zixiu; Daniels, J Scott; Jones, Carrie K; Lindsley, Craig W; Weaver, C David; Conn, P Jeffrey
信号转导
神经科学
代谢
发表日期：2012
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Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

mGlu5正变构调节剂醚系列的优化：MPEP位点相互作用交叉的分子决定因素

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2012.08.043
Manka, Jason T; Vinson, Paige N; Gregory, Karen J; Zhou, Ya; Williams, Richard; Gogi, Kiran; Days, Emily; Jadhav, Satya; Herman, Elizabeth J; Lavreysen, Hilde; Mackie, Claire; Bartolomé, José M; Macdonald, Gregor J; Steckler, Thomas; Daniels, J Scott; Weaver, C David; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R
发表日期：2012
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