日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma

缺氧会促进BCMA丢失和抑制性分泌组的形成，从而阻碍CAR-T细胞疗法在多发性骨髓瘤中的应用。

期刊:Experimental Hematology & Oncology
影响因子:13.5
doi:10.1186/s40164-025-00732-6
Tu, Chenggong; Van der Vreken, Arne; Meeus, Fien; van den Broecke, Lauren; Brons, Jack; De Veirman, Kim; Vanderkerken, Karin; De Bruyne, Elke; Breckpot, Karine; Menu, Eline
T细胞
多发性骨髓瘤
T细胞
骨髓瘤
细胞生物学
免疫/内分泌
发表日期：2026
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Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia

OPRM1 过度甲基化：肌痛性脑脊髓炎/慢性疲劳综合征和纤维肌痛中内源性阿片通路失调

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27020826
Wyns, Arne; Hendrix, Jolien; Van Campenhout, Jente; Buntinx, Yanthe; Xiong, Huan-Yu; De Bruyne, Elke; Godderis, Lode; Nijs, Jo; Rice, David; Chiang, Daniel; Polli, Andrea
表观遗传
信号转导
神经科学
纤维肌痛综合征
OPRM
发表日期：2026
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PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

骨髓基质细胞中 PYCR1 的抑制可通过改变其代谢来增强多发性骨髓瘤细胞对硼替佐米的敏感性。

期刊:Molecular Oncology
影响因子:4.5
doi:10.1002/1878-0261.70120
Oudaert, Inge; van den Broecke, Lauren; Aksoy, Osman; Lind, Judith; Vallet, Sonia; Van der Vreken, Arne; Ates, Gamze; Massie, Ann; Maes, Ken; De Veirman, Kim; De Bruyne, Elke; Vanderkerken, Karin; Podar, Klaus; Menu, Eline
CR1
多发性骨髓瘤
代谢
基质细胞
PYC
骨髓瘤
细胞生物学
发表日期：2026
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Correction: Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma

更正：用于局部治疗多发性骨髓瘤溶骨性骨病和微小残留病灶的硼替佐米释放二氧化硅-胶原蛋白干凝胶

期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-025-01663-9
Hose, Dirk; Ray, Seemun; Rößler, Sina; Thormann, Ulrich; Schnettler, Reinhard; de Veirman, Kim; Khassawna, Thaqif El; Heiss, Christian; Hild, Anne; Zahner, Daniel; Alagboso, Francisca; Henss, Anja; Beck, Susanne; Emde-Rajaratnam, Martina; Burhenne, Jürgen; Bamberger, Juliane; Menu, Eline; de Bruyne, Elke; Gelinsky, Michael; Kampschulte, Marian; Rohnke, Marcus; Wenisch, Sabine; Vanderkerken, Karin; Hanke, Thomas; Seckinger, Anja; Alt, Volker
多发性骨髓瘤
骨髓瘤
发表日期：2025
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Syntenin inhibition impairs stroma-tumor communication in multiple myeloma and improves bortezomib treatment efficiency.

Syntenin 抑制剂会损害多发性骨髓瘤中的基质-肿瘤通讯，并提高硼替佐米治疗的疗效

期刊:Hemasphere
影响因子:14.6
doi:10.1002/hem3.70197
Tu Chenggong, Leblanc Raphael, Van der Vreken Arne, Koops Marnix, Audebert Stephane, Goullieux Lauriane, Meeussen Sofie, De Veirman Kim, De Bruyne Elke, Vanderkerken Karin, David Guido, Cupedo Tom, Zimmermann Pascale, Menu Eline
肿瘤
发表日期：2025
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The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse

从头DNA甲基转移酶3B是多发性骨髓瘤中MYC的一种新型表观遗传调控因子，代表了一种有前景的治疗靶点，可用于对抗复发

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-025-03382-y
Muylaert, Catharina; Van Hemelrijck, Lien Ann; Van der Vreken, Arne; Heestermans, Robbe; Satilmis, Hatice; Verheye, Emma; Alaterre, Elina; Olsen, Catharina; De Beule, Nathan; De Veirman, Kim; Menu, Eline; Vanderkerken, Karin; Moreaux, Jérôme; De Bruyne, Elke
表观遗传
多发性骨髓瘤
信号转导
骨髓瘤
MYC
发表日期：2025
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Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy

免疫肽组学鉴定出用于多发性骨髓瘤治疗中含α-半乳糖神经酰胺的mRNA-脂质纳米颗粒疫苗的抗原

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2024-010673
Van der Vreken, Arne; Thery, Fabien; Tu, Chenggong; Mwangi, Kevin; Meulewaeter, Sofie; De Beck, Lien; Janssens, Edith; De Veirman, Kim; Vanderkerken, Karin; De Bruyne, Elke; Franceschini, Lorenzo; Impens, Francis; Verbeke, Rein; Lentacker, Ine; Menu, Eline; Breckpot, Karine
多发性骨髓瘤
免疫/内分泌
骨髓瘤
发表日期：2025
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Blood-derived cell-free DNA is a superior biomarker for noninvasive DNA methylation profiling in multiple myeloma

血液来源的游离DNA是多发性骨髓瘤无创DNA甲基化谱分析的优良生物标志物。

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2025016480
Heestermans, Robbe; Olsen, Catharina; Ameli, Shervine; Succari, Jana; Janssen, Toon; De Brouwer, Wouter; De Becker, Ann; Vande Broek, Isabelle; Bakkus, Marleen; Schots, Rik; De Bruyne, Elke; Van Riet, Ivan
多发性骨髓瘤
表观遗传
DNA甲基化
骨髓瘤
发表日期：2025
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Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma

利用 G-四链体稳定剂靶向多发性骨髓瘤中的转录-复制冲突

期刊:
影响因子:
doi:10.1016/j.bneo.2025.100072
Dutrieux, Laure; Ovejero, Sara; Guillemin, Antoine; Zellagui, Miss Leriem; De Bruyne, Elke; Muylaert, Catharina; Van Hemelrijck, Lien; Lin, Yea-Lih; Loughran, Elle; Choquet, Armelle; Magat, Talha; Bouchouika, Soumya; Bret, Caroline; Requirand, Guilhem; Robert, Nicolas; Vincent, Laure; Cartron, Guillaume; Herbaux, Charles; Rodriguez, Raphaël; Cogné, Michel; Rivals, Eric; Andrau, Jean-Christophe; David, Alexandre; Pasero, Philippe; Moreaux, Jérôme
多发性骨髓瘤
骨髓瘤
发表日期：2025
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Fueling CARs: metabolic strategies to enhance CAR T-cell therapy

CAR-T细胞疗法的动力来源：代谢策略

期刊:Experimental Hematology & Oncology
影响因子:13.5
doi:10.1186/s40164-024-00535-1
Van der Vreken, Arne; Vanderkerken, Karin; De Bruyne, Elke; De Veirman, Kim; Breckpot, Karine; Menu, Eline
T细胞
代谢
T细胞
细胞生物学
免疫/内分泌
发表日期：2024
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