日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A senescent tumor cell-derived nanovesicle directly primes splenic T cells to potentiate cancer radiotherapy

衰老肿瘤细胞衍生的纳米囊泡可直接激活脾脏T细胞，从而增强癌症放射治疗的效果。

期刊:Cell Reports Medicine
影响因子:10.6
doi:10.1016/j.xcrm.2026.102709
Pan, Jiaxing; Zhang, Shun; Xu, Yuchentian; Li, Zhuoliang; Luo, Meiqin; Peng, Zirui; Jin, Aojia; Hou, Bo; Qin, Xiji; Cui, Xingang; De Geest, Bruno G; Chen, Yuanwen; Xu, Zhiai; Yu, Haijun; Lai, Yi
囊泡
衰老
免疫/内分泌
细胞生物学
T细胞
肿瘤细胞
肿瘤
肿瘤免疫
T细胞
发表日期：2026
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Antibody-Recruiting Surfaces Using Adaptive Multicomponent Supramolecular Copolymers

利用自适应多组分超分子共聚物的抗体募集表面

期刊:Biomacromolecules
影响因子:5.4
doi:10.1021/acs.biomac.5c00043
Vleugels, Marle E J; de Korver, Esmee; Hendrikse, Simone I S; Kardas, Sinan; Dhiman, Shikha; de Waal, Bas F M; Schoenmakers, Sandra M C; Wijker, Stefan; De Geest, Bruno G; Surin, Mathieu; Palmans, Anja R A; Meijer, E W
发表日期：2025
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Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist.

通过肿瘤内联合治疗，将奥沙利铂和咪唑喹啉 TLR7/8 激动剂的两亲性缀合物与肿瘤内联合治疗，增强抗肿瘤免疫力

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra00163c
Verschuere Hanne, Kasmi Sabah, Nuhn Lutz, D'Almeida Sènan Mickaël, Zhu Qiwen, Zhong Zifu, Adjemian Sandy, Louage Benoit, De Vrieze Jana, Yu Haijun, De Geest Bruno G, Vandenabeele Peter
肿瘤
肿瘤免疫
发表日期：2025
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Enhancing functional antibody responses against HIV envelope V1V2 through vaccine formulations

通过疫苗制剂增强针对HIV包膜V1V2的功能性抗体反应

期刊:Frontiers in Immunology
影响因子:
doi:10.3389/fimmu.2025.1722596
Yengo, Clauvis Kunkeng; Liu, Xiaomei; Laghlali, Gabriel; Park, Seok-Chan; Klingler, Jéromine; Luo, Christina C; Jiang, Xunqing; Kong, Xiang-Peng; Rao, Priyanka G; Upadhyay, Chitra; Wiest, Matthew J; Muramatsu, Hiromi; De Geest, Bruno G; Wong, Pamela T; Tam, Ying; Pardi, Norbert; Schotsaert, Michael; Hioe, Catarina E
HIV
微生物学
发表日期：2025
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A combination TLR7/8 and RIG-I agonist adjuvant reverts asthmatic allergic sensitization and prevents aggravated influenza infection in OVA-sensitized mice.

TLR7/8 和 RIG-I 激动剂的组合佐剂可逆转哮喘过敏反应，并防止 OVA 致敏小鼠的流感感染加重

期刊:
影响因子:
doi:10.1101/2025.06.23.659362
Diego Juan García-Bernalt, Burgess Eleanor, Chang Lauren A, Prellberg Matthew, Noureddine Moataz, Sadek Naseem, Chen Yong, El-Ayache Farah, Laghlali Gabriel, Park Seok-Chan, Yan Vivian, Wong Pamela T, De Geest Bruno G, Tomalka Jeffrey A, Schotsaert Michael
炎症/感染
哮喘
流感
发表日期：2025
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Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity

脂质纳米颗粒包封赋予聚肌苷酸胞苷酸（Poly(I:C)）激活胞质RLR的能力，从而增强其佐剂活性。

期刊:Small
影响因子:12.1
doi:10.1002/smll.202306892
Lamoot, Alexander; Jangra, Sonia; Laghlali, Gabriel; Warang, Prajakta; Singh, Gagandeep; Chang, Lauren A; Park, Seok-Chan; Singh, Gagandeep; De Swarte, Kim; Zhong, Zifu; Louage, Benoit; De Lombaerde, Emily; Ye, Tingting; Chen, Yong; Cuadrado-Castano, Sara; Lienenklaus, Stefan; Sanders, Niek N; Lambrecht, Bart N; García-Sastre, Adolfo; Schotsaert, Michael; De Geest, Bruno G
发表日期：2024
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PH-Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2-Propionic-3-Methyl-maleic Anhydrides with Cholesteryl End Groups

利用胆固醇末端基团的聚合物2-丙酸-3-甲基马来酸酐实现PH触发的淋巴结靶向免疫药物释放

期刊:Advanced Healthcare Materials
影响因子:9.6
doi:10.1002/adhm.202402875
Heck, Alina G; Medina-Montano, Carolina; Zhong, Zifu; Deswarte, Kim; Eigen, Katharina; Stickdorn, Judith; Kockelmann, Johannes; Scherger, Maximilian; Sanders, Niek N; Lienenklaus, Stefan; Lambrecht, Bart N; Grabbe, Stephan; De Geest, Bruno G; Nuhn, Lutz
代谢
免疫/内分泌
发表日期：2024
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Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo

双配体PROTACS在体外可介导更优异的靶蛋白降解，并在体内展现出治疗效果。

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d4sc03555k
Chen, Yong; Xia, Zihan; Suwal, Ujjwal; Rappu, Pekka; Heino, Jyrki; De Wever, Olivier; De Geest, Bruno G
蛋白降解
发表日期：2024
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Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice

用于佐剂配方的脂质纳米颗粒组合物可调节四价流感疫苗接种小鼠感染流感病毒后的疾病。

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2024.1370564
Jangra, Sonia; Lamoot, Alexander; Singh, Gagandeep; Laghlali, Gabriel; Chen, Yong; Ye, Tingting; García-Sastre, Adolfo; De Geest, Bruno G; Schotsaert, Michael
炎症/感染
流感
微生物学
发表日期：2024
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Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice

用于佐剂配方的脂质纳米颗粒组合物可调节接种四价流感疫苗小鼠感染流感病毒后的疾病。

期刊:
影响因子:
doi:10.1101/2024.01.14.575599
Jangra, Sonia; Lamoot, Alexander; Singh, Gagandeep; Laghlali, Gabriel; Chen, Yong; Yz, Tingting; García-Sastre, Adolfo; De Geest, Bruno G; Schotsaert, Michael
炎症/感染
流感
微生物学
发表日期：2024
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