日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen

从DNA编码文库筛选中发现E3连接酶STUB1/CHIP的小分子配体

Lucas, Simon C C; Milbradt, Alexander G; Breed, Jason; De Genst, Erwin; Jackson, Anne; Solovyeva, Alisa; Ackroyd, Bryony; Bauer, Matthias R; Liu, Juntai; Longmire, David; Petrović, Dušan; Rivers, Emma L; Stubbs, Christopher; Winlow, Poppy; Bazzaz, Sana; Dickson, Paige; Gikunju, Diana; Guié, Marie-Aude; Guilinger, John P; Hupp, Christopher D; Jetson, Rachael; Keefe, Anthony D; Nugai, Katherine; Yeoman, John T S; Zhang, Ying; Feng, Xian; Yu, Dequan; Phillips, Christopher

Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure

用 VHH 胞内抗体阻断受磷蛋白可增强心力衰竭的收缩力和舒张力

Erwin De Genst, Kylie S Foo, Yao Xiao, Eduarde Rohner, Emma de Vries, Jesper Sohlmér, Nevin Witman, Alejandro Hidalgo, Terje R S Kolstad, William E Louch, Susanne Pehrsson, Andrew Park, Yasuhiro Ikeda, Xidan Li, Lorenz M Mayr, Kate Wickson, Karin Jennbacken, Kenny Hansson, Regina Fritsche-Danielson,

An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation

mRNA 检测系统证明蛋白酶体特异性降解导致心肌病受磷蛋白无效突变

Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E Louch, Makoto Sahara, Kenneth R Chien

Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model

蛋白酶体靶向纳米抗体可减轻基于α-突触核蛋白的帕金森病模型中的病理变化和功能衰退。

Chatterjee, Diptaman; Bhatt, Mansi; Butler, David; De Genst, Erwin; Dobson, Christopher M; Messer, Anne; Kordower, Jeffrey H

Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model

α-突触核蛋白/Grp94 免疫重塑外周免疫并抑制慢性帕金森病模型中的微胶质增生

Javier Villadiego, Adahir Labrador-Garrido, Jaime M Franco, Magdalena Leal-Lasarte, Erwin J De Genst, Christopher M Dobson, David Pozo, Juan J Toledo-Aral, Cintia Roodveldt

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

通过研究磷酸化对纳米抗体结合的影响探索翻译后修饰在调节 α-突触核蛋白相互作用中的作用

Farah El Turk, Erwin De Genst, Tim Guilliams, Bruno Fauvet, Mirva Hejjaoui, Justin Di Trani, Anass Chiki, Anthony Mittermaier, Michele Vendruscolo, Hilal A Lashuel, Christopher M Dobson

Silk micrococoons for protein stabilisation and molecular encapsulation

用于蛋白质稳定和分子封装的丝微茧

Ulyana Shimanovich, Francesco S Ruggeri, Erwin De Genst, Jozef Adamcik, Teresa P Barros, David Porter, Thomas Müller, Raffaele Mezzenga, Christopher M Dobson, Fritz Vollrath, Chris Holland, Tuomas P J Knowles

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

针对单体 ɑ-突触核蛋白的纳米抗体可抑制原纤维形成并破坏有毒寡聚物种类

Marija Iljina, Liu Hong, Mathew H Horrocks, Marthe H Ludtmann, Minee L Choi, Craig D Hughes, Francesco S Ruggeri, Tim Guilliams, Alexander K Buell, Ji-Eun Lee, Sonia Gandhi, Steven F Lee, Clare E Bryant, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson, Erwin De Genst, David Klenerman

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation

应用赖氨酸特异性标记检测人类溶菌酶淀粉样纤维形成过程中存在的瞬时相互作用

Minkoo Ahn, Christopher A Waudby, Ana Bernardo-Gancedo, Erwin De Genst, Anne Dhulesia, Xavier Salvatella, John Christodoulou, Christopher M Dobson, Janet R Kumita

Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response

分子伴侣筛选结果显示 Grp94/Gp96 和 FKBP4/52 是 α-突触核蛋白引发的免疫反应的调节剂

Adahir Labrador-Garrido, Marta Cejudo-Guillén, Soumya Daturpalli, María M Leal, Rebecca Klippstein, Erwin J De Genst, Javier Villadiego, Juan J Toledo-Aral, Christopher M Dobson, Sophie E Jackson, David Pozo, Cintia Roodveldt